Protein: AVR2B
Activin receptor type-2B (EC 2.7.11.30) (Activin receptor type IIB) (ACTR-IIB)

Gene: AVR2B, ACVR2B
Organism: Homo sapiens
Interactions: 100
UniProt ID: Q13705

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001702 - gastrulation with mouth forming second
GO:0001822 - kidney development
GO:0001946 - lymphangiogenesis
GO:0001974 - blood vessel remodeling

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

787295

ACV1B
Activin receptor type-1B

5

19

Small-scale

0.908

High

470369

INHBA
Inhibin beta A chain

4

20

Small-scale

0.873

High

788919

TGFR2
TGF-beta receptor type-2

3

19

High-throughput

0.861

High

845423

PE2R3
Prostaglandin E2 receptor EP3 subtype

3

4

High-throughput

0.861

High

690086

AVR2A
Activin receptor type-2A

3

20

Small-scale

0.839

High

720608

GRPR
Gastrin-releasing peptide receptor

2

3

High-throughput

0.811

High

335387

GDF11
Growth/differentiation factor 11

2

20

Small-scale

0.799

High

483487

INHBB
Inhibin beta B chain

2

20

Small-scale

0.789

High

787159

BMR1A
Bone morphogenetic protein receptor type-1A

2

20

Small-scale

0.789

High

164764

GDF8
Growth/differentiation factor 8

2

20

Small-scale

0.785

High

787395

TGFR1
TGF-beta receptor type-1

2

19

High-throughput

0.776

High

821715

CD79B
B-cell antigen receptor complex-associated protein beta chain

2

0

High-throughput

0.770

High

554131

BMP2
Bone morphogenetic protein 2

2

20

Small-scale

0.768

High

1116836

LRIQ1
Leucine-rich repeat- and IQ domain-containing protein 1

2

20

High-throughput

0.726

High

406884

MAS
Proto-oncogene Mas

1

3

High-throughput

0.691

High

484137

PGFRB
Platelet-derived growth factor receptor beta

1

13

High-throughput

0.691

High

522658

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

6

High-throughput

0.691

High

692058

MARK3
MAP/microtubule affinity-regulating kinase 3

1

4

High-throughput

0.691

High

1034231

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.691

High

1048352

ACVR1
Activin receptor type-1

1

20

High-throughput

0.691

High

1062966

DDR1
Epithelial discoidin domain-containing receptor 1

1

20

High-throughput

0.691

High

1096426

PAK1
Serine/threonine-protein kinase PAK 1

1

8

High-throughput

0.691

High

1116810

CNGA3
Cyclic nucleotide-gated channel alpha-3

1

8

High-throughput

0.691

High

1116811

CDC37
Hsp90 co-chaperone Cdc37

1

1

High-throughput

0.691

High

1116817

PKN3
Serine/threonine-protein kinase N3

1

4

High-throughput

0.691

High

1116821

NLRX1
NLR family member X1

1

11

High-throughput

0.691

High

1116835

KIRR1
Kin of IRRE-like protein 1

1

3

High-throughput

0.691

High

1116837

ERBIN
Erbin

1

20

Small-scale

0.681

High

1010030

DLK1
Protein delta homolog 1

3

8

High-throughput

0.667

High

1116846

CC50A
Cell cycle control protein 50A

3

3

High-throughput

0.667

High

1116832

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

0

High-throughput

0.656

High

335549

BMP10
Bone morphogenetic protein 10

1

20

Small-scale

0.647

High

1116838

NODAL
Nodal homolog

1

20

Small-scale

0.647

High

1116849

GDF2
Growth/differentiation factor 2

1

20

Small-scale

0.647

High

1116854

PCDG5
Protocadherin gamma-A5

2

5

High-throughput

0.628

High

1116844

RAB6B
Ras-related protein Rab-6B

1

10

High-throughput

0.618

High

461461

HS90A
Heat shock protein HSP 90-alpha

1

16

High-throughput

0.618

High

468358

HS90B
Heat shock protein HSP 90-beta

1

16

High-throughput

0.618

High

611727

BMP7
Bone morphogenetic protein 7

1

20

Small-scale

0.618

High

643196

BMP6
Bone morphogenetic protein 6

1

20

Small-scale

0.618

High

845234

GDF5
Growth/differentiation factor 5

1

20

Small-scale

0.618

High

1116840

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

6

High-throughput

0.618

High

1116823

IZUM1
Izumo sperm-egg fusion protein 1

2

0

High-throughput

0.602

High

1116839

Q96T11
Receptor-interacting serine/threonine-protein kinase 4

1

5

High-throughput

0.575

High

1116850

HECD1
E3 ubiquitin-protein ligase HECTD1

1

19

High-throughput

0.575

High

180991

LRAD4
Low-density lipoprotein receptor class A domain-containing protein 4

2

1

High-throughput

0.558

High

62228

A4D1W7
Inhibin beta A chain

1

20

Small-scale

0.553

High

163301

TR10B
Tumor necrosis factor receptor superfamily member 10B

1

11

High-throughput

0.536

High

190359

COPT1
High affinity copper uptake protein 1

1

2

High-throughput

0.536

High

665040

IL4RA
Interleukin-4 receptor subunit alpha

1

1

High-throughput

0.536

High

850874

KI3L2
Killer cell immunoglobulin-like receptor 3DL2

1

8

High-throughput

0.536

High

907707

CLCN3
H(+)/Cl(-) exchange transporter 3

1

1

High-throughput

0.536

High

1116813

TTMP
TPA-induced transmembrane protein

1

2

High-throughput

0.536

High

1116815

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

1

1

High-throughput

0.536

High

1116822

DEN6A
Protein DENND6A

1

1

High-throughput

0.536

High

1116824

AGRG5
Adhesion G-protein coupled receptor G5

1

3

High-throughput

0.536

High

1116826

I17RC
Interleukin-17 receptor C

1

2

High-throughput

0.536

High

1116827

RN149
E3 ubiquitin-protein ligase RNF149

1

11

High-throughput

0.536

High

1116828

S20A1
Sodium-dependent phosphate transporter 1

1

2

High-throughput

0.536

High

1116829

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

1

11

High-throughput

0.536

High

1116831

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

3

High-throughput

0.536

High

1116833

MRAP2
Melanocortin-2 receptor accessory protein 2

1

5

High-throughput

0.536

High

1116842

MARH7
E3 ubiquitin-protein ligase MARCHF7

1

6

High-throughput

0.536

High

1116843

I17RB
Interleukin-17 receptor B

1

1

High-throughput

0.536

High

1116847

FMN2
Formin-2

1

3

High-throughput

0.536

High

1116851

PCDGG
Protocadherin gamma-B4

1

5

High-throughput

0.536

High

1116855

S12A7
Solute carrier family 12 member 7

1

3

High-throughput

0.536

High

1116856

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

6

High-throughput

0.536

High

155462

C2C2L
Phospholipid transfer protein C2CD2L

1

0

High-throughput

0.513

High

921501

MVD1
Diphosphomevalonate decarboxylase

1

0

High-throughput

0.513

High

1116814

IQEC2
IQ motif and SEC7 domain-containing protein 2

1

0

High-throughput

0.513

High

1116818

KCNT2
Potassium channel subfamily T member 2

1

0

High-throughput

0.513

High

561357

TDGF1
Protein Cripto

1

7

Small-scale

0.501

High

1116853

FBX7
F-box only protein 7

1

1

High-throughput

0.501

High

71384

HECA2
HEPACAM family member 2

1

4

High-throughput

0.489

High

698640

CALX
Calnexin

1

7

High-throughput

0.489

High

1116819

PKHH3
Pleckstrin homology domain-containing family H member 3

1

2

High-throughput

0.489

High

1116830

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

12

High-throughput

0.489

High

1116834

RUSF1
RUS family member 1

1

3

High-throughput

0.489

High

1116841

MANS1
MANSC domain-containing protein 1

1

2

High-throughput

0.489

High

1116845

GINM1
Glycoprotein integral membrane protein 1

1

2

High-throughput

0.489

High

1116848

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

6

High-throughput

0.489

High

944380

SYJ2B
Synaptojanin-2-binding protein

1

4

Small-scale

0.481

High

138100

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

4

Small-scale

0.479

High

177681

SMAD7
Mothers against decapentaplegic homolog 7

1

20

Small-scale

0.479

High

219862

SMAD6
Mothers against decapentaplegic homolog 6

1

20

Small-scale

0.479

High

255422

SNX2
Sorting nexin-2

1

8

Small-scale

0.479

High

608261

EGLN
Endoglin

1

12

Small-scale

0.479

High

1111911

SNX1
Sorting nexin-1

1

9

Small-scale

0.479

High

1116809

SMAD2
Mothers against decapentaplegic homolog 2

1

20

Small-scale

0.479

High

1116816

RGMB
Repulsive guidance molecule B

1

6

Small-scale

0.479

High

1116820

PEG10
Retrotransposon-derived protein PEG10

1

8

Small-scale

0.479

High

1116825

IGSF1
Immunoglobulin superfamily member 1

1

7

Small-scale

0.479

High

1116852

SNX6
Sorting nexin-6

1

8

Small-scale

0.479

High

1087048

FSTL1
Follistatin-related protein 1

1

5

Small-scale

0.457

High

388407

B3AT
Band 3 anion transport protein

1

7

High-throughput

0.445

High

722783

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

0

High-throughput

0.426

High

1116812

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

2

High-throughput

0.407

High

72656

UPK3L
Uroplakin-3b-like protein 1

1

0

High-throughput

0.279

Low

328242

NDUA3
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025