HitPredict

Interactor 1: MTOR (P42345)
Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1)
Gene: MTOR

Interactor 2: 1433G (P61981)
14-3-3 protein gamma (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein gamma, N-terminally processed]
Gene: YWHAG

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35271311, 36931259
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0032869 - cellular response to insulin stimulus
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 2549 Hs			1 247
+	Hs
		787440 MTOR_HUMAN (1-2549): 0: 2102: 100.00		1433E_HUMAN (1-244): 2.02e-141: 398: 63.53
+	Hs
		787460 MTOR_HUMAN (1-2549): 0: 2102: 100.00		1433F_HUMAN (1-246): 2.5e-135: 382: 86.99
+	Hs
		683184 MTOR_HUMAN (1-2549): 0: 2102: 100.00		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		787451 MTOR_HUMAN (1-2549): 0: 2102: 100.00		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		646705 MTOR_HUMAN (1-2549): 0: 2102: 100.00		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Hs
		683882 MTOR_HUMAN (1-2549): 0: 2102: 100.00		1433S_HUMAN (2-245): 1.86e-98: 289: 65.16
+	Hs
		927004 ATM_HUMAN (387-2548): 0: 894: 14.98		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		905297 TRRAP_HUMAN (925-2548): 0: 720: 15.53		1433G_HUMAN (1-247): 3.15e-139: 392: 100.00
+	At
		788647 ATM_ARATH (401-2548): 0: 704: 13.98		14333_ARATH (1-244): 4.4e-142: 400: 61.79
+	Hs
		904439 PRKDC_HUMAN (695-2548): 0: 686: 14.83		1433G_HUMAN (1-247): 3.15e-139: 392: 100.00
+	Hs
		683847 TRRAP_HUMAN (925-2548): 0: 720: 15.53		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		683261 PRKDC_HUMAN (695-2548): 0: 686: 14.83		1433B_HUMAN (2-247): 1.91e-109: 317: 75.40
+	Hs
		926917 PRKDC_HUMAN (695-2548): 0: 686: 14.83		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		646792 PRKDC_HUMAN (695-2548): 0: 686: 14.83		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Hs
		904645 Q4LE69_HUMAN (733-2453): 1.63e-160: 553: 12.12		1433G_HUMAN (1-247): 3.15e-139: 392: 100.00
+	Hs
		982077 Q4LE69_HUMAN (733-2453): 1.63e-160: 553: 12.12		1433F_HUMAN (1-246): 2.5e-135: 382: 86.99
+	Hs
		927364 GCN1_HUMAN (245-1372): 1.05e-38: 162: 12.17		1433Z_HUMAN (2-245): 2.39e-108: 314: 74.59
+	Hs
		647159 GCN1_HUMAN (245-1372): 1.05e-38: 162: 12.17		1433T_HUMAN (2-245): 5.53e-105: 305: 70.33
+	Dm
		664613 Q7K3H0_DROME (1898-2419): 8.48e-26: 119: 19.33		1433Z_DROME (2-242): 1.36e-108: 314: 74.69