Protein: AVR2A
Activin receptor type-2A (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA) (ACTRIIA)

Gene: AVR2A, ACVR2A
Organism: Homo sapiens
Interactions: 99
UniProt ID: P27037

Gene Ontology (top 5):
GO:0001649 - osteoblast differentiation
GO:0001702 - gastrulation with mouth forming second
GO:0001934 - positive regulation of protein phosphorylation
GO:0004674 - protein serine/threonine kinase activity
GO:0004675 - transmembrane receptor protein serine/threonine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

554124

BMP2
Bone morphogenetic protein 2

6

20

Small-scale

0.939

High

470363

INHBA
Inhibin beta A chain

6

20

Small-scale

0.935

High

690073

ACV1B
Activin receptor type-1B

5

20

Small-scale

0.912

High

690077

PE2R3
Prostaglandin E2 receptor EP3 subtype

3

4

High-throughput

0.861

High

483484

INHBB
Inhibin beta B chain

3

20

Small-scale

0.853

High

690086

AVR2B
Activin receptor type-2B

3

20

Small-scale

0.839

High

611705

BMP7
Bone morphogenetic protein 7

3

20

Small-scale

0.827

High

690110

HAVR2
Hepatitis A virus cellular receptor 2

2

3

High-throughput

0.811

High

690075

TGFR2
TGF-beta receptor type-2

2

20

High-throughput

0.789

High

690136

GDF2
Growth/differentiation factor 2

2

20

Small-scale

0.778

High

643190

BMP6
Bone morphogenetic protein 6

2

20

Small-scale

0.768

High

690074

ACVL1
Activin receptor type-1-like

2

20

Small-scale

0.754

High

690085

ACVR1
Activin receptor type-1

2

20

Small-scale

0.754

High

690117

LRIQ1
Leucine-rich repeat- and IQ domain-containing protein 1

2

20

High-throughput

0.726

High

165906

FFAR1
Free fatty acid receptor 1

1

2

High-throughput

0.691

High

252324

TLR2
Toll-like receptor 2

1

20

High-throughput

0.691

High

295562

CIB2
Calcium and integrin-binding family member 2

1

5

High-throughput

0.691

High

322529

SLIK3
SLIT and NTRK-like protein 3

1

20

High-throughput

0.691

High

463903

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

10

High-throughput

0.691

High

690079

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

1

High-throughput

0.691

High

690084

CD83
CD83 antigen

1

2

High-throughput

0.691

High

690091

TIGIT
T-cell immunoreceptor with Ig and ITIM domains

1

1

High-throughput

0.691

High

690095

BT2A1
Butyrophilin subfamily 2 member A1

1

1

High-throughput

0.691

High

690111

IGDC4
Immunoglobulin superfamily DCC subclass member 4

1

8

High-throughput

0.691

High

690129

FLRT1
Leucine-rich repeat transmembrane protein FLRT1

1

20

High-throughput

0.691

High

690142

GPR45
Probable G-protein coupled receptor 45

1

3

High-throughput

0.691

High

690119

ERBIN
Erbin

1

20

Small-scale

0.681

High

335539

BMP10
Bone morphogenetic protein 10

1

20

Small-scale

0.647

High

554158

BMP4
Bone morphogenetic protein 4

1

20

Small-scale

0.647

High

690120

NODAL
Nodal homolog

1

20

Small-scale

0.647

High

690114

MRAP2
Melanocortin-2 receptor accessory protein 2

2

5

High-throughput

0.628

High

690138

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

1

High-throughput

0.618

High

424299

INHA
Inhibin alpha chain

1

20

Small-scale

0.618

High

601176

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.618

High

690072

BMR1A
Bone morphogenetic protein receptor type-1A

1

19

Small-scale

0.618

High

690076

GDF5
Growth/differentiation factor 5

1

20

Small-scale

0.618

High

690087

BMPR2
Bone morphogenetic protein receptor type-2

1

20

Small-scale

0.618

High

690096

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

180981

LRAD4
Low-density lipoprotein receptor class A domain-containing protein 4

3

1

High-throughput

0.609

High

608223

EGLN
Endoglin

2

12

Small-scale

0.584

High

254820

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

8

High-throughput

0.575

High

690139

RNF11
RING finger protein 11

2

14

High-throughput

0.574

High

71379

HECA2
HEPACAM family member 2

2

4

High-throughput

0.558

High

690126

GINM1
Glycoprotein integral membrane protein 1

2

2

High-throughput

0.558

High

690080

SYJ2B
Synaptojanin-2-binding protein

2

4

Small-scale

0.556

High

690104

MIRO2
Mitochondrial Rho GTPase 2

1

20

High-throughput

0.553

High

690135

TSP50
Probable threonine protease PRSS50

1

4

Small-scale

0.552

High

127639

TR10A
Tumor necrosis factor receptor superfamily member 10A

1

8

High-throughput

0.536

High

190311

COPT1
High affinity copper uptake protein 1

1

2

High-throughput

0.536

High

475895

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

3

High-throughput

0.536

High

602863

INAR1
Interferon alpha/beta receptor 1

1

15

High-throughput

0.536

High

690083

EFNB1
Ephrin-B1

1

1

High-throughput

0.536

High

690092

TTMP
TPA-induced transmembrane protein

1

2

High-throughput

0.536

High

690097

KCNKI
Potassium channel subfamily K member 18

1

5

High-throughput

0.536

High

690099

DAAM2
Disheveled-associated activator of morphogenesis 2

1

3

High-throughput

0.536

High

690100

T150A
Transmembrane protein 150A

1

1

High-throughput

0.536

High

690103

TCAM2
TIR domain-containing adapter molecule 2

1

1

High-throughput

0.536

High

690107

RN149
E3 ubiquitin-protein ligase RNF149

1

11

High-throughput

0.536

High

690109

MARH1
E3 ubiquitin-protein ligase MARCHF1

1

8

High-throughput

0.536

High

690112

TR19L
Tumor necrosis factor receptor superfamily member 19L

1

5

High-throughput

0.536

High

690116

AB17A
Alpha/beta hydrolase domain-containing protein 17A

1

3

High-throughput

0.536

High

690118

OPALI
Opalin

1

3

High-throughput

0.536

High

690122

PCDC1
Protocadherin alpha-C1

1

6

High-throughput

0.536

High

690123

CRLF2
Cytokine receptor-like factor 2

1

5

High-throughput

0.536

High

690125

CP26B
Cytochrome P450 26B1

1

1

High-throughput

0.536

High

690128

GPC5B
G-protein coupled receptor family C group 5 member B

1

2

High-throughput

0.536

High

690131

MARH2
E3 ubiquitin-protein ligase MARCHF2

1

8

High-throughput

0.536

High

690132

CCG4
Voltage-dependent calcium channel gamma-4 subunit

1

2

High-throughput

0.536

High

690133

TR10D
Tumor necrosis factor receptor superfamily member 10D

1

8

High-throughput

0.536

High

690137

EDAR
Tumor necrosis factor receptor superfamily member EDAR

1

4

High-throughput

0.536

High

690141

PCDB3
Protocadherin beta-3

1

5

High-throughput

0.536

High

690143

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

6

High-throughput

0.536

High

575115

IDE
Insulin-degrading enzyme

1

0

High-throughput

0.513

High

690093

TRML2
Trem-like transcript 2 protein

1

0

High-throughput

0.513

High

690108

TLC3A
TLC domain-containing protein 3A

1

0

High-throughput

0.513

High

561344

TDGF1
Protein Cripto

1

7

Small-scale

0.501

High

690071

CALX
Calnexin

1

6

High-throughput

0.489

High

690081

CTXN1
Cortexin-1

1

1

High-throughput

0.489

High

690089

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

2

High-throughput

0.489

High

690098

CLC14
C-type lectin domain family 14 member A

1

1

High-throughput

0.489

High

690105

NRSN1
Neurensin-1

1

2

High-throughput

0.489

High

690115

RUSF1
RUS family member 1

1

3

High-throughput

0.489

High

690124

TMM9B
Transmembrane protein 9B

1

4

High-throughput

0.489

High

690127

EVA1B
Protein eva-1 homolog B

1

2

High-throughput

0.489

High

690102

MAGI2
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

1

10

Small-scale

0.481

High

690094

RGMB
Repulsive guidance molecule B

1

6

Small-scale

0.479

High

690101

PEG10
Retrotransposon-derived protein PEG10

1

8

Small-scale

0.479

High

690106

IGSF1
Immunoglobulin superfamily member 1

1

7

Small-scale

0.479

High

690121

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

1

High-throughput

0.479

High

690140

TRAF6
TNF receptor-associated factor 6

1

6

Small-scale

0.479

High

690134

DAXX
Death domain-associated protein 6

1

1

Small-scale

0.464

High

388375

B3AT
Band 3 anion transport protein

1

7

High-throughput

0.445

High

690082

DLK1
Protein delta homolog 1

1

8

High-throughput

0.445

High

690088

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

3

High-throughput

0.445

High

690078

LEG7
Galectin-7

1

0

High-throughput

0.426

High

690090

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

2

High-throughput

0.407

High

547312

CP19A
Aromatase

1

0

High-throughput

0.279

Low

690113

F131C
Protein FAM131C

1

0

High-throughput

0.279

Low

690130

AKA7G
A-kinase anchor protein 7 isoform gamma

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025