HitPredict

Interactor 1: EPS15 (P42566)
Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)
Gene: EPS15

Interactor 2: EPN3 (Q9H201)
Epsin-3 (EPS-15-interacting protein 3)
Gene: EPN3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	21115825
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0005905 - clathrin-coated pit GO:0006897 - endocytosis GO:0043231 - intracellular membrane-bounded organelle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 896 Hs			1 632
+	Hs
		787913 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		EPN4_HUMAN (3-628): 4.33e-76: 256: 21.77
+	Hs
		787997 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		EPN1_HUMAN (1-592): 3.16e-57: 204: 37.64
+	Hs
		787860 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		EPS15_HUMAN (38-569): 4e-46: 177: 10.26
+	Hs
		161630 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		GAK_HUMAN (173-548): 3.67e-40: 159: 16.46
+	Mm
		787998 EPS15_MOUSE (1-896): 6.54e-132: 419: 88.54		EPS15_MOUSE (38-558): 2.8e-43: 169: 10.11
+	Rn
		1126747 Q5JC29_RAT (1-774): 7.44e-120: 384: 88.79		SYNJ1_RAT (43-625): 1.84e-39: 157: 11.17
+	Hs
		61732 A6H8W8_HUMAN (6-845): 1.24e-62: 233: 14.86		EPS15_HUMAN (38-569): 4e-46: 177: 10.26
+	Hs
		787985 ITSN2_HUMAN (3-845): 2.31e-61: 229: 14.40		EPS15_HUMAN (38-569): 4e-46: 177: 10.26
+	Hs
		307533 ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61		EPN2_HUMAN (1-632): 5.11e-66: 229: 33.54
+	Mm
		1194353 ITSN1_MOUSE (2-737): 1.82e-38: 158: 11.80		EPN1_MOUSE (1-592): 7.73e-58: 206: 36.72
+	Hs
		787920 ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61		EPS15_HUMAN (38-569): 4e-46: 177: 10.26
+	Ce
		1308343 Q9U2T9_CAEEL (5-425): 1.07e-23: 109: 11.85		Q9BI71_CAEEL (1-526): 5.09e-64: 220: 30.06
+	Ce
		1308345 Q9U2T9_CAEEL (5-425): 1.07e-23: 109: 11.85		Q9BI72_CAEEL (1-526): 4.75e-64: 220: 30.25
+	Mm
		788010 ITSN1_MOUSE (2-737): 1.82e-38: 158: 11.80		EPS15_MOUSE (38-558): 2.8e-43: 169: 10.11
+	Cl
		47357 F1PHV6_CANLF (2-476): 6.6e-38: 156: 14.91		A0A8I3PJA6_CANLF (38-545): 3.35e-43: 168: 9.58
+	Dm
		91160 E3CTP7_DROME (10-209): 3.99e-30: 129: 43.27		Q7KU90_DROME (1-622): 4.26e-51: 191: 26.90
+	Ce
		1259347 Q8WSP1_CAEEL (117-215): 2.67e-20: 98.2: 50.51		Q9BI72_CAEEL (1-526): 4.75e-64: 220: 30.25
+	Rn
		92844 ITSN1_RAT (11-737): 4.81e-34: 143: 12.14		E9PSY8_RAT (38-569): 1.21e-42: 166: 10.64
+	Mm
		1194352 EHD1_MOUSE (17-102): 8.82e-16: 83.5: 32.56		EPN1_MOUSE (1-592): 7.73e-58: 206: 36.72
+	Hs
		203228 ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61		SYNJ1_HUMAN (291-630): 4.09e-11: 68.5: 12.15