HitPredict

Interactor 1: EPS15 (P42566)
Epidermal growth factor receptor substrate 15 (Protein Eps15) (Protein AF-1p)
Gene: EPS15

Interactor 2: UBQL1 (Q9UMX0)
Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) (hPLIC-1)
Gene: UBQLN1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.677

Property	Details
Experiments	17082820, 16159959, 18199683
Identification Methods	pull down, two hybrid, affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016235 - aggresome GO:0031593 - polyubiquitin modification-dependent protein binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 896 Hs			1 589
+	Hs
		787990 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		UBQL2_HUMAN (1-589): 9.51e-145: 433: 71.29
+	Hs
		787970 EPS15_HUMAN (1-896): 5.15e-160: 493: 100.00		UBQL3_HUMAN (17-553): 8.35e-105: 331: 38.88
+	Hs
		1349281 ITSN2_HUMAN (3-845): 2.31e-61: 229: 14.40		UBQL2_HUMAN (1-589): 9.51e-145: 433: 71.29
+	Hs
		1078927 ITSN1_HUMAN (2-520): 3.13e-38: 157: 14.61		UBQL2_HUMAN (1-589): 9.51e-145: 433: 71.29
+	Hs
		1353929 EP15R_HUMAN (417-891): 5.86e-14: 78.3: 11.98		UBQL1_HUMAN (1-589): 1.23e-174: 509: 100.00
+	Hs
		1353926 EP15R_HUMAN (417-891): 5.86e-14: 78.3: 11.98		UBQL2_HUMAN (1-589): 9.51e-145: 433: 71.29
+	Ce
		107545 Q9U2T9_CAEEL (5-425): 1.07e-23: 109: 11.85		UBQL_CAEEL (31-586): 1.66e-115: 354: 36.30
+	Dm
		91153 E3CTP7_DROME (10-209): 3.99e-30: 129: 43.27		RS27A_DROME (37-107): 1.11e-12: 68: 36.11
+	Sc
		477621 END3_YEAST (15-378): 4.53e-13: 73.6: 17.73		RL40A_YEAST (37-129): 2.22e-31: 120: 28.72