HitPredict

Interactor 1: CASP3 (P42574)
Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
Gene: CASP3

Interactor 2: XIAP (P98170)
E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
Gene: XIAP

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.994

The method score is based on:

Property Details
Experiments 26186194, 28514442, 11257232, 33961781, 9230442, 16869888, 9525868, 18723680, 23074197, 27927753, 30522111, 11447297, 11927604, 9384571, 11359776, 15200957, 22072751, 15507451, 12624662, 18521960 and 15 others

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Identification Methods affinity chromatography technology, x-ray crystallography, pull down, enzymatic study, anti tag coimmunoprecipitation, protease assay
Interaction Type physical association, association, direct interaction, protein cleavage

The annotation score is based on:

Property Details
Interacting Pfam domains BIR~Peptidase_C14
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006974 - DNA damage response
and 1 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 277
Hs

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Last updated: 15 Jul 2024