HitPredict

Interactor 1: CASP2 (P42575)
Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
Gene: CASP2

Interactor 2: TRAF1 (Q13077)
TNF receptor-associated factor 1 (Epstein-Barr virus-induced protein 6)
Gene: TRAF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	29875129
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006915 - apoptotic process
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 452 Hs			1 416
+	Mm
		669121 CASP2_MOUSE (1-452): 1.8e-179: 510: 89.60		TRAF1_MOUSE (1-416): 4.49e-160: 458: 84.38
+	Hs
		788249 CASP2_HUMAN (1-452): 0: 519: 100.00		TRAF2_HUMAN (3-415): 4e-124: 370: 38.01
+	Mm
		669122 CASP2_MOUSE (1-452): 1.8e-179: 510: 89.60		TRAF2_MOUSE (3-415): 3.91e-127: 378: 37.77
+	Hs
		1023660 CASP8_HUMAN (32-446): 1.84e-120: 361: 21.29		TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00
+	Hs
		181606 CFLAR_HUMAN (16-445): 2.38e-113: 343: 18.74		TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00
+	Hs
		877026 CASP6_HUMAN (168-447): 1.12e-105: 317: 25.98		TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00
+	Hs
		1023744 CASPA_HUMAN (16-396): 7.11e-100: 310: 23.66		TRAF1_HUMAN (1-416): 4.57e-172: 489: 100.00
+	Hs
		667455 CASP1_HUMAN (32-449): 1.66e-133: 392: 23.29		TRAF2_HUMAN (3-415): 4e-124: 370: 38.01
+	Hs
		1020664 CASP8_HUMAN (32-446): 1.84e-120: 361: 21.29		TRAF2_HUMAN (3-415): 4e-124: 370: 38.01
+	Hs
		181605 CFLAR_HUMAN (16-445): 2.38e-113: 343: 18.74		TRAF2_HUMAN (3-415): 4e-124: 370: 38.01
+	Hs
		876940 CASP7_HUMAN (132-445): 3.79e-112: 334: 26.98		TRAF2_HUMAN (3-415): 4e-124: 370: 38.01
+	Hs
		1059404 CASP8_HUMAN (32-446): 1.84e-120: 361: 21.29		TRAF6_HUMAN (15-414): 1.57e-103: 318: 22.98
+	Hs
		1020747 CASPC_HUMAN (109-449): 8.51e-102: 308: 21.43		TRAF2_HUMAN (3-415): 4e-124: 370: 38.01
+	Mm
		292696 CASP8_MOUSE (31-447): 1.03e-120: 362: 21.98		TRAF6_MOUSE (15-414): 1.94e-101: 313: 22.51
+	Hs
		830308 CASP4_HUMAN (33-449): 2.67e-119: 355: 21.23		TRAF6_HUMAN (15-414): 1.57e-103: 318: 22.98
+	Hs
		788251 CASP2_HUMAN (1-452): 0: 519: 100.00		TRAF3_HUMAN (3-262): 9.64e-11: 65.3: 15.77
+	Hs
		181607 CFLAR_HUMAN (16-445): 2.38e-113: 343: 18.74		TRAF3_HUMAN (3-262): 9.64e-11: 65.3: 15.77
+	Hs
		788188 CASP3_HUMAN (188-446): 3.26e-108: 323: 28.85		TRAF3_HUMAN (3-262): 9.64e-11: 65.3: 15.77