HitPredict

Interactor 1: WASP (P42768)
Actin nucleation-promoting factor WAS (Wiskott-Aldrich syndrome protein) (WASp)
Gene: WAS

Interactor 2: PTN22 (Q9Y2R2)
Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP) (Lymphoid phosphatase) (LyP) (PEST-domain phosphatase) (PEP)
Gene: PTPN22

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	19167335
Identification Methods	phosphatase assay
Interaction Type	dephosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0017124 - SH3 domain binding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 502 Hs			1 807
+	Hs
		790663 WASP_HUMAN (1-487): 8.09e-99: 308: 100.00		PTN12_HUMAN (1-696): 0: 723: 36.81
+	Mm
		728825 WASP_MOUSE (17-487): 1.16e-101: 316: 86.04		PTN12_MOUSE (1-696): 0: 692: 35.36
+	Hs
		126912 WASL_HUMAN (15-311): 1.14e-115: 352: 47.67		PTN2_HUMAN (26-399): 3.73e-129: 393: 28.76
+	Hs
		616908 WASP_HUMAN (1-487): 8.09e-99: 308: 100.00		PTPRB_HUMAN (18-314): 2.09e-117: 393: 31.19
+	Hs
		617086 WASP_HUMAN (1-487): 8.09e-99: 308: 100.00		PTPRG_HUMAN (30-294): 3.35e-51: 196: 25.54
+	Hs
		617160 WASP_HUMAN (1-487): 8.09e-99: 308: 100.00		PTPRZ_HUMAN (30-323): 4.58e-51: 196: 24.43
+	Hs
		490001 CBP_HUMAN (107-498): 6.15e-40: 156: 13.65		PTPRF_HUMAN (6-292): 1.61e-101: 347: 36.77
+	Hs
		790667 WASP_HUMAN (1-487): 8.09e-99: 308: 100.00		PTPRJ_HUMAN (15-295): 2.81e-48: 187: 38.10
+	Hs
		790677 WASP_HUMAN (1-487): 8.09e-99: 308: 100.00		PTPRO_HUMAN (45-299): 3.56e-43: 171: 38.22
+	Hs
		441188 WASP_HUMAN (1-487): 8.09e-99: 308: 100.00		PTPRC_HUMAN (61-462): 5.14e-11: 68.6: 9.24
+	Hs
		840677 DYN2_HUMAN (244-438): 9.39e-25: 110: 17.54		PTN11_HUMAN (287-497): 2.12e-12: 72.5: 14.09