HitPredict

Interactor 1: CDN2C (P42773)
Cyclin-dependent kinase 4 inhibitor C (Cyclin-dependent kinase 6 inhibitor) (p18-INK4c) (p18-INK6)
Gene: CDKN2C

Interactor 2: MK10 (P53779)
Mitogen-activated protein kinase 10 (MAP kinase 10) (MAPK 10) (EC 2.7.11.24) (MAP kinase p49 3F12) (Stress-activated protein kinase 1b) (SAPK1b) (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3)
Gene: MAPK10

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	16007099
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ank_2~Pkinase, Ank_4~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 168 Hs			1 464
+	Hs
		790957 CDN2C_HUMAN (1-168): 3.27e-53: 168: 100.00		MK08_HUMAN (39-464): 5.15e-162: 465: 90.87
+	Hs
		790718 CDN2A_HUMAN (3-140): 5.49e-22: 88.2: 39.57		MK10_HUMAN (1-464): 0: 517: 100.00
+	Hs
		790703 CDN2A_HUMAN (3-140): 5.49e-22: 88.2: 39.57		MK08_HUMAN (39-464): 5.15e-162: 465: 90.87
+	Hs
		625621 RAI14_HUMAN (1-135): 3.41e-37: 136: 21.32		CDK2_HUMAN (61-365): 1.42e-136: 396: 34.41
+	Hs
		790791 CDN2A_HUMAN (3-140): 5.49e-22: 88.2: 39.57		MK14_HUMAN (42-408): 2.57e-133: 390: 45.95
+	Mm
		814053 MIB1_MOUSE (74-168): 3.38e-14: 71.1: 21.88		MK14_MOUSE (42-408): 1.63e-133: 391: 45.95
+	Hs
		658832 CDN2C_HUMAN (1-168): 3.27e-53: 168: 100.00		MK01_HUMAN (58-397): 8.71e-85: 266: 42.98
+	Hs
		658871 CDN2D_HUMAN (6-159): 4e-48: 155: 45.81		MK01_HUMAN (58-397): 8.71e-85: 266: 42.98
+	Rn
		926518 CSKI1_RAT (1-159): 7.2e-30: 116: 14.69		MK01_RAT (53-397): 1.25e-84: 266: 42.37
+	Hs
		647524 DAPK1_HUMAN (42-168): 1.97e-29: 114: 20.93		MK03_HUMAN (58-397): 1.2e-84: 266: 42.12
+	Hs
		658865 DAPK1_HUMAN (42-168): 1.97e-29: 114: 20.93		MK01_HUMAN (58-397): 8.71e-85: 266: 42.98
+	Hs
		647496 CDN2A_HUMAN (3-140): 5.49e-22: 88.2: 39.57		MK03_HUMAN (58-397): 1.2e-84: 266: 42.12
+	Hs
		658830 CDN2A_HUMAN (3-140): 5.49e-22: 88.2: 39.57		MK01_HUMAN (58-397): 8.71e-85: 266: 42.98
+	Hs
		658831 CDN2B_HUMAN (9-122): 1.23e-20: 84: 45.22		MK01_HUMAN (58-397): 8.71e-85: 266: 42.98
+	Rn
		926505 TANC1_RAT (82-168): 3.37e-12: 65.4: 22.47		MK01_RAT (53-397): 1.25e-84: 266: 42.37