Protein: VAV3
Guanine nucleotide exchange factor VAV3 (VAV-3)

Gene: VAV3
Organism: Homo sapiens
Interactions: 53
UniProt ID: Q9UKW4

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0001772 - immunological synapse
GO:0002768 - immune response-regulating cell surface receptor signaling pathway
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005096 - GTPase activator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

988017

GRB2
Growth factor receptor-bound protein 2

7

20

Small-scale

0.968

High

364011

EGFR
Epidermal growth factor receptor

6

20

Small-scale

0.931

High

411109

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

High-throughput

0.778

High

641700

ERBB3
Receptor tyrosine-protein kinase erbB-3

2

20

High-throughput

0.778

High

962621

RHOA
Transforming protein RhoA

2

20

Small-scale

0.778

High

472143

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.692

High

532106

KIT
Mast/stem cell growth factor receptor Kit

1

20

High-throughput

0.692

High

1106514

GAB1
GRB2-associated-binding protein 1

1

20

High-throughput

0.692

High

988811

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

Small-scale

0.647

High

1015896

RHOG
Rho-related GTP-binding protein RhoG

1

20

Small-scale

0.647

High

1145793

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

439876

INSR
Insulin receptor

1

20

Small-scale

0.618

High

465690

IGF1R
Insulin-like growth factor 1 receptor

1

20

Small-scale

0.618

High

477269

ROS1
Proto-oncogene tyrosine-protein kinase ROS

1

20

Small-scale

0.618

High

484240

PGFRB
Platelet-derived growth factor receptor beta

1

20

Small-scale

0.618

High

699889

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

20

Small-scale

0.618

High

711428

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.618

High

1098860

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

7

High-throughput

0.618

High

1256043

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

1357680

BLNK
B-cell linker protein

1

20

Small-scale

0.618

High

1097960

CBLB
E3 ubiquitin-protein ligase CBL-B

2

20

High-throughput

0.606

High

1459266

ZRAN1
Ubiquitin thioesterase ZRANB1

2

5

High-throughput

0.606

High

1238627

RINT1
RAD50-interacting protein 1

2

0

High-throughput

0.580

High

1063026

DDR1
Epithelial discoidin domain-containing receptor 1

1

20

Small-scale

0.575

High

1461291

ALK
ALK tyrosine kinase receptor

1

20

Small-scale

0.575

High

756402

MCM7
DNA replication licensing factor MCM7

2

7

High-throughput

0.571

High

987497

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

2

4

High-throughput

0.571

High

1248096

FIP1
Pre-mRNA 3'-end-processing factor FIP1

2

1

High-throughput

0.571

High

1461292

NOP58
Nucleolar protein 58

2

3

High-throughput

0.571

High

1004318

3BP2
SH3 domain-binding protein 2

1

12

Small-scale

0.553

High

520440

ANDR
Androgen receptor

1

18

High-throughput

0.536

High

397189

ESR1
Estrogen receptor

1

19

Small-scale

0.527

High

1461293

LC7L2
Putative RNA-binding protein Luc7-like 2

2

2

High-throughput

0.521

High

211448

RFOX2
RNA binding protein fox-1 homolog 2

1

9

High-throughput

0.479

High

251672

CCNT1
Cyclin-T1

1

2

High-throughput

0.479

High

1058718

CKAP4
Cytoskeleton-associated protein 4

1

18

High-throughput

0.479

High

1093993

TRAF1
TNF receptor-associated factor 1

1

4

Small-scale

0.479

High

1095006

TRAF3
TNF receptor-associated factor 3

1

13

Small-scale

0.479

High

1114624

CUL3
Cullin-3

1

8

High-throughput

0.479

High

1203633

ZN326
DBIRD complex subunit ZNF326

1

1

High-throughput

0.479

High

1294127

DDX42
ATP-dependent RNA helicase DDX42

1

5

High-throughput

0.479

High

1360524

PSPC1
Paraspeckle component 1

1

11

High-throughput

0.479

High

1461294

TRAF6
TNF receptor-associated factor 6

1

13

Small-scale

0.479

High

1461295

TNR11
Tumor necrosis factor receptor superfamily member 11A

1

5

Small-scale

0.479

High

367617

CAH2
Carbonic anhydrase 2

1

0

High-throughput

0.458

High

1435648

AAMDC
Mth938 domain-containing protein

1

0

High-throughput

0.458

High

784763

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

2

High-throughput

0.437

High

895675

SERPH
Serpin H1

1

7

High-throughput

0.437

High

1096268

TADBP
TAR DNA-binding protein 43

1

14

High-throughput

0.437

High

1403299

RBM15
RNA-binding protein 15

1

10

High-throughput

0.437

High

1402397

CLCC1
Chloride channel CLIC-like protein 1

2

0

High-throughput

0.298

High

569149

T2FB
General transcription factor IIF subunit 2

1

0

High-throughput

0.249

Low

1205107

FA76B
Protein FAM76B

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025