HitPredict

Interactor 1: CDN2C (P42773)
Cyclin-dependent kinase 4 inhibitor C (Cyclin-dependent kinase 6 inhibitor) (p18-INK4c) (p18-INK6)
Gene: CDKN2C

Interactor 2: CDK6 (Q00534)
Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE)
Gene: CDK6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.991

The method score is based on:

Property Details
Experiments 25910212, 28514442, 17353931, 27107012, 10022865, 28205554, 8001816, 33961781, 25416956, 26186194, 12370184, 32296183, 11124804, 32707033, 23602568, 31515488, unassigned1304, 18394558, 25502805, 8840966
Identification Methods two hybrid, affinity chromatography technology, pull down, fluorescent resonance energy transfer, x-ray crystallography, two hybrid prey pooling approach, two hybrid array, anti bait coimmunoprecipitation, barcode fusion genetics two hybrid, split luciferase complementation and 4 others

more...
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Ank_2~Pkinase, Ank_4~Pkinase
Common GO terms GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0008285 - negative regulation of cell population proliferation
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 168
Hs

1 326
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Last updated: 15 Jul 2024