HitPredict

Interactor 1: HD (P42858)
Huntingtin (Huntington disease protein) (HD protein) [Cleaved into: Huntingtin, myristoylated N-terminal fragment]
Gene: HTT

Interactor 2: HAP1 (P54257)
Huntingtin-associated protein 1 (HAP-1) (Neuroan 1)
Gene: HAP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.743

The method score is based on:

Property	Details
Experiments	30994454, 15383276, 9454836, 7477378, 9668110, 18192679
Identification Methods	affinity chromatography technology, two hybrid, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005769 - early endosome GO:0005776 - autophagosome GO:0005783 - endoplasmic reticulum GO:0005814 - centriole GO:0005829 - cytosol and 5 others more... GO:0016234 - inclusion body GO:0030425 - dendrite GO:0031587 - positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity GO:0044325 - transmembrane transporter binding GO:0047496 - vesicle transport along microtubule
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1	3142
Hs

1	671

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024