HitPredict

Interactor 1: SYUA (P37840)
Alpha-synuclein (Non-A beta component of AD amyloid) (Non-A4 component of amyloid precursor) (NACP)
Gene: SNCA

Interactor 2: OPTN (Q96CV9)
Optineurin (E3-14.7K-interacting protein) (FIP-2) (Huntingtin yeast partner L) (Huntingtin-interacting protein 7) (HIP-7) (Huntingtin-interacting protein L) (NEMO-related protein) (Optic neuropathy-inducing protein) (Transcription factor IIIA-interacting protein) (TFIIIA-IntP)
Gene: OPTN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	39079530
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0008270 - zinc ion binding GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 140 Hs			1 577
+	Hs
		791879 SYUA_HUMAN (1-140): 1e-57: 177: 100.00		MRCKB_HUMAN (61-518): 2.29e-50: 189: 17.47
+	Hs
		587579 SYUA_HUMAN (1-140): 1e-57: 177: 100.00		DESP_HUMAN (6-529): 1.19e-16: 86.2: 11.77
+	Hs
		791387 SYUA_HUMAN (1-140): 1e-57: 177: 100.00		NUMA1_HUMAN (2-577): 7.29e-14: 77.1: 9.55
+	Hs
		773113 SYUA_HUMAN (1-140): 1e-57: 177: 100.00		MYH10_HUMAN (184-572): 1.13e-13: 76.8: 11.83
+	Hs
		772650 SYUA_HUMAN (1-140): 1e-57: 177: 100.00		MYH9_HUMAN (194-572): 1.9e-13: 76: 14.81