HitPredict

Interactor 1: MUC18 (P43121)
Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146)
Gene: MCAM

Interactor 2: TNIK (Q9UKE5)
TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1)
Gene: TNIK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	38117590
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~V-set
Common GO terms	-
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 646 Hs			1 1360
+	Hs
		793390 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		MINK1_HUMAN (1-1360): 0: 1051: 60.43
+	Hs
		324758 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		M4K4_HUMAN (1-1360): 0: 970: 59.11
+	Mm
		1206831 PTK7_MOUSE (141-613): 9.65e-54: 201: 15.07		MINK1_MOUSE (1-1360): 0: 1066: 62.01
+	Mm
		956967 PTK7_MOUSE (141-613): 9.65e-54: 201: 15.07		M4K4_MOUSE (1-1360): 0: 946: 58.91
+	Hs
		793347 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		MRCKA_HUMAN (12-1330): 0: 690: 13.75
+	Hs
		793543 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		MRCKB_HUMAN (15-1330): 0: 661: 15.04
+	Hs
		234459 DSCAM_HUMAN (265-506): 2.21e-09: 63.2: 25.76		M4K4_HUMAN (1-1360): 0: 970: 59.11
+	Hs
		793320 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		KS6A2_HUMAN (10-709): 1.39e-140: 449: 18.52
+	Hs
		647841 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		MARK3_HUMAN (3-675): 1.72e-124: 406: 16.37
+	Hs
		793468 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		TAOK3_HUMAN (14-514): 8.99e-109: 367: 29.92
+	Hs
		793321 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		KS6A1_HUMAN (2-350): 9.65e-97: 329: 22.63
+	Rn
		530226 NCAM1_RAT (11-644): 2.13e-86: 290: 15.78		ROCK1_RAT (14-951): 5.86e-126: 425: 15.39
+	Hs
		793541 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		M4K5_HUMAN (19-373): 7.89e-73: 263: 40.38
+	Hs
		1071679 KIRR1_HUMAN (240-644): 1.88e-28: 123: 15.77		KS6A2_HUMAN (10-709): 1.39e-140: 449: 18.52
+	Dm
		1249844 Q9VQW7_DROME (25-345): 8.83e-21: 99.6: 16.42		HIPPO_DROME (1-317): 1.07e-107: 357: 38.89