HitPredict

Interactor 1: MUC18 (P43121)
Cell surface glycoprotein MUC18 (Cell surface glycoprotein P1H12) (Melanoma cell adhesion molecule) (Melanoma-associated antigen A32) (Melanoma-associated antigen MUC18) (S-endo 1 endothelial-associated antigen) (CD antigen CD146)
Gene: MCAM

Interactor 2: MRCKB (Q9Y5S2)
Serine/threonine-protein kinase MRCK beta (EC 2.7.11.1) (CDC42-binding protein kinase beta) (CDC42BP-beta) (DMPK-like beta) (Myotonic dystrophy kinase-related CDC42-binding kinase beta) (MRCK beta) (Myotonic dystrophy protein kinase-like beta)
Gene: CDC42BPB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	38117590
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~V-set
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 646 Hs			1 1711
+	Hs
		793347 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		MRCKA_HUMAN (1-1710): 0: 1386: 60.78
+	Rn
		530226 NCAM1_RAT (11-644): 2.13e-86: 290: 15.78		ROCK1_RAT (2-1188): 0: 608: 25.57
+	Hs
		296399 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		STK10_HUMAN (43-1015): 1.26e-120: 406: 16.50
+	Hs
		793516 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		TNIK_HUMAN (52-833): 5.89e-94: 336: 14.30
+	Hs
		793320 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		KS6A2_HUMAN (2-389): 6.73e-94: 323: 21.41
+	Hs
		793321 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		KS6A1_HUMAN (2-354): 1.8e-89: 310: 22.16
+	Hs
		793488 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		LATS2_HUMAN (66-375): 4.05e-70: 259: 40.34
+	Hs
		149131 PXDN_HUMAN (183-555): 5.6e-61: 222: 20.77		CTRO_HUMAN (5-1085): 8.52e-127: 442: 24.93
+	Hs
		530144 NCAM1_HUMAN (11-644): 1.38e-81: 277: 15.63		KAPCA_HUMAN (48-375): 1.99e-119: 382: 34.72
+	Hs
		254456 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		ROCK2_HUMAN (362-1073): 2.09e-23: 110: 13.59
+	Hs
		148187 DSCAM_HUMAN (265-506): 2.21e-09: 63.2: 25.76		CTRO_HUMAN (5-1085): 8.52e-127: 442: 24.93
+	Hs
		793302 MUC18_HUMAN (1-646): 3.41e-136: 414: 100.00		ROCK1_HUMAN (360-1074): 6.44e-17: 89.6: 13.02
+	Hs
		1264826 TITIN_HUMAN (50-634): 4.44e-11: 68.6: 11.22		ST38L_HUMAN (1-421): 5.35e-120: 388: 37.93
+	Hs
		1071679 KIRR1_HUMAN (240-644): 1.88e-28: 123: 15.77		KS6A2_HUMAN (2-389): 6.73e-94: 323: 21.41