HitPredict

Interactor 1: KI3L1 (P43629)
Killer cell immunoglobulin-like receptor 3DL1 (CD158 antigen-like family member E) (HLA-BW4-specific inhibitory NK cell receptor) (Natural killer-associated transcript 3) (NKAT-3) (p70 natural killer cell receptor clones CL-2/CL-11) (p70 NK receptor CL-2/CL-11) (CD antigen CD158e)
Gene: KIR3DL1

Interactor 2: KI2S2 (P43631)
Killer cell immunoglobulin-like receptor 2DS2 (CD158 antigen-like family member J) (NK receptor 183 ActI) (Natural killer-associated transcript 5) (NKAT-5) (p58 natural killer cell receptor clone CL-49) (p58 NK receptor CL-49) (CD antigen CD158j)
Gene: KIR2DS2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	ig~ig
Common GO terms	GO:0005886 - plasma membrane GO:0006955 - immune response
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 444 Hs			1 304
+	Hs
		798163 KI3L1_HUMAN (1-444): 1.25e-115: 347: 100.00		KI2L2_HUMAN (1-303): 8.23e-107: 316: 95.71
+	Hs
		798136 KI3L1_HUMAN (1-444): 1.25e-115: 347: 100.00		KI2L1_HUMAN (1-303): 7.68e-106: 314: 91.09
+	Hs
		47501 A0A8I5QEB2_HUMAN (1-427): 3.73e-100: 306: 72.83		KI2S5_HUMAN (1-304): 2.21e-115: 336: 91.78
+	Hs
		798168 KI3S1_HUMAN (1-369): 9.59e-97: 297: 95.66		KI2L2_HUMAN (1-303): 8.23e-107: 316: 95.71
+	Hs
		798235 KI3L1_HUMAN (1-444): 1.25e-115: 347: 100.00		KI3S1_HUMAN (1-251): 4.2e-57: 190: 38.19
+	Hs
		1232785 LIRB2_HUMAN (1-444): 6.31e-57: 199: 29.94		LIRB4_HUMAN (1-304): 1.14e-71: 229: 30.60
+	Hs
		252781 LIRA6_HUMAN (1-442): 4.2e-60: 205: 26.75		LIRB3_HUMAN (1-257): 5.57e-63: 211: 30.27
+	Hs
		252771 LIRA3_HUMAN (1-342): 1.66e-71: 234: 35.06		LIRA1_HUMAN (21-246): 2.6e-41: 151: 37.66
+	Hs
		1235887 LIRA3_HUMAN (1-342): 1.66e-71: 234: 35.06		LIRB1_HUMAN (21-246): 1.28e-39: 148: 37.66
+	Hs
		1235888 LIRA3_HUMAN (1-342): 1.66e-71: 234: 35.06		U5XH19_HUMAN (21-246): 9.58e-39: 144: 35.07
+	Hs
		1161634 LIRA6_HUMAN (1-442): 4.2e-60: 205: 26.75		U5XH19_HUMAN (21-246): 9.58e-39: 144: 35.07
+	Hs
		87574 C9JWL8_HUMAN (1-341): 1.37e-57: 202: 32.09		U5XH19_HUMAN (21-246): 9.58e-39: 144: 35.07
+	Hs
		1232784 LIRA3_HUMAN (1-342): 1.66e-71: 234: 35.06		LIRB2_HUMAN (10-138): 5.62e-15: 77.1: 36.43