Protein: RIOK3
Serine/threonine-protein kinase RIO3 (EC 2.7.11.1) (RIO kinase 3) (sudD homolog)

Gene: RIOK3
Organism: Homo sapiens
Interactions: 91
UniProt ID: O14730

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0007059 - chromosome segregation
GO:0030490 - maturation of SSU-rRNA

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

161773

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

5

4

Small-scale

0.722

High

161795

RS16
Small ribosomal subunit protein uS9

1

5

High-throughput

0.691

High

161802

RS25
Small ribosomal subunit protein eS25

1

4

High-throughput

0.691

High

161807

RACK1
Small ribosomal subunit protein RACK1

4

6

High-throughput

0.691

High

161831

CASPA
Caspase-10

2

0

Small-scale

0.634

High

161775

RS2
Small ribosomal subunit protein uS5

2

4

High-throughput

0.628

High

161789

RS20
Small ribosomal subunit protein uS10

2

3

High-throughput

0.611

High

161801

RS24
Small ribosomal subunit protein eS24

2

3

High-throughput

0.611

High

161762

RIOK3
Serine/threonine-protein kinase RIO3

1

3

Small-scale

0.575

High

161812

GRB7
Growth factor receptor-bound protein 7

2

1

High-throughput

0.571

High

161771

RS17
Small ribosomal subunit protein eS17

1

4

High-throughput

0.536

High

161772

RSSA
Small ribosomal subunit protein uS2

1

7

High-throughput

0.536

High

161780

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.536

High

161781

RS19
Small ribosomal subunit protein eS19

1

5

High-throughput

0.536

High

161786

RS10
Small ribosomal subunit protein eS10

1

5

High-throughput

0.536

High

161792

RS7
Small ribosomal subunit protein eS7

1

5

High-throughput

0.536

High

161793

RS8
Small ribosomal subunit protein eS8

1

4

High-throughput

0.536

High

161794

RS15A
Small ribosomal subunit protein uS8

1

4

High-throughput

0.536

High

161796

RS18
Small ribosomal subunit protein uS13

1

3

High-throughput

0.536

High

161797

RS11
Small ribosomal subunit protein uS17

1

4

High-throughput

0.536

High

161798

RS4X
Small ribosomal subunit protein eS4, X isoform

1

3

High-throughput

0.536

High

161799

RS6
Small ribosomal subunit protein eS6

1

4

High-throughput

0.536

High

161800

RS15
Small ribosomal subunit protein uS19

1

3

High-throughput

0.536

High

161803

RS26
Small ribosomal subunit protein eS26

1

3

High-throughput

0.536

High

161804

RS28
Small ribosomal subunit protein eS28

1

5

High-throughput

0.536

High

161805

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

4

High-throughput

0.536

High

161806

RS21
Small ribosomal subunit protein eS21

1

5

High-throughput

0.536

High

161811

BYST
Bystin

1

4

High-throughput

0.536

High

161816

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

4

High-throughput

0.536

High

161826

ASCC3
Activating signal cointegrator 1 complex subunit 3

1

8

High-throughput

0.536

High

161832

LTV1
Protein LTV1 homolog

1

2

High-throughput

0.536

High

161836

OSBL5
Oxysterol-binding protein-related protein 5

1

2

High-throughput

0.536

High

161841

PNO1
RNA-binding protein PNO1

1

3

High-throughput

0.536

High

161845

NOB1
RNA-binding protein NOB1

1

4

High-throughput

0.536

High

161819

CR3L3
Cyclic AMP-responsive element-binding protein 3-like protein 3

1

0

High-throughput

0.518

High

161785

PRS6B
26S proteasome regulatory subunit 6B

1

1

High-throughput

0.515

High

161847

RUVB2
RuvB-like 2

1

5

High-throughput

0.515

High

161813

IRF3
Interferon regulatory factor 3

1

0

Small-scale

0.513

High

161815

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.513

High

161835

IFIH1
Interferon-induced helicase C domain-containing protein 1

1

8

Small-scale

0.506

High

161840

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

2

Small-scale

0.501

High

161777

PSB1
Proteasome subunit beta type-1

1

0

High-throughput

0.493

High

161776

NUCL
Nucleolin

1

3

High-throughput

0.489

High

161810

KRR1
KRR1 small subunit processome component homolog

1

2

High-throughput

0.489

High

161822

SPT6H
Transcription elongation factor SPT6

1

2

High-throughput

0.489

High

161808

PAK2
Serine/threonine-protein kinase PAK 2

1

3

High-throughput

0.481

High

161844

TBK1
Serine/threonine-protein kinase TBK1

1

0

Small-scale

0.479

High

123502

MYO1C
Unconventional myosin-Ic

1

3

High-throughput

0.479

High

161763

XPO1
Exportin-1

1

9

High-throughput

0.479

High

161765

XRCC3
DNA repair protein XRCC3

1

1

High-throughput

0.479

High

161766

EVI5
Ecotropic viral integration site 5 protein homolog

1

2

High-throughput

0.479

High

161768

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

161769

HERC2
E3 ubiquitin-protein ligase HERC2

1

3

High-throughput

0.479

High

161782

ARL1
ADP-ribosylation factor-like protein 1

1

1

High-throughput

0.479

High

161788

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

2

High-throughput

0.479

High

161791

RS3A
Small ribosomal subunit protein eS1

1

6

High-throughput

0.479

High

161809

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

161824

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

161843

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

161778

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

1

High-throughput

0.470

High

161764

B2L11
Bcl-2-like protein 11

1

0

High-throughput

0.460

High

161790

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.460

High

94399

D6RAT0
Small ribosomal subunit protein eS1

1

6

High-throughput

0.445

High

161818

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.445

High

161770

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.437

High

161814

HAPR1
HUWE1-associated protein modifying stress responses 1

1

1

High-throughput

0.437

High

161827

EMC5
ER membrane protein complex subunit 5

1

1

High-throughput

0.437

High

161829

TM9S4
Transmembrane 9 superfamily member 4

1

1

High-throughput

0.437

High

161774

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

161783

EAA1
Excitatory amino acid transporter 1

1

0

High-throughput

0.426

High

161779

H1T
Histone H1t

1

4

High-throughput

0.407

High

161820

ZNT6
Zinc transporter 6

1

1

High-throughput

0.407

High

161825

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

1

High-throughput

0.407

High

161846

XCT
Cystine/glutamate transporter

1

1

High-throughput

0.407

High

161767

TULP3
Tubby-related protein 3

2

0

High-throughput

0.320

High

161849

KCNE3
Potassium voltage-gated channel subfamily E member 3

2

0

High-throughput

0.313

High

161830

SEPT8
Septin-8

1

0

High-throughput

0.279

Low

161833

MYCT
Proton myo-inositol cotransporter

1

0

High-throughput

0.279

Low

161837

ASCC2
Activating signal cointegrator 1 complex subunit 2

1

0

High-throughput

0.279

Low

161838

ADAM7
Disintegrin and metalloproteinase domain-containing protein 7

1

0

High-throughput

0.279

Low

161839

ZMAT3
Zinc finger matrin-type protein 3

1

0

High-throughput

0.279

Low

161848

UBIA1
UbiA prenyltransferase domain-containing protein 1

1

0

High-throughput

0.279

Low

161784

MAGA6
Melanoma-associated antigen 6

1

0

High-throughput

0.269

Low

161787

SSRD
Translocon-associated protein subunit delta

1

0

High-throughput

0.269

Low

161828

FBX25
F-box only protein 25

1

0

Small-scale

0.261

Low

161821

FBX42
F-box only protein 42

1

0

High-throughput

0.249

Low

161817

SL9C2
Sodium/hydrogen exchanger 11

1

0

High-throughput

0.232

Low

161823

MOT9
Monocarboxylate transporter 9

1

0

High-throughput

0.232

Low

161834

S17A9
Voltage-gated purine nucleotide uniporter SLC17A9

1

0

High-throughput

0.232

Low

161842

S39A9
Zinc transporter ZIP9

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025