Protein: RIOK2
Serine/threonine-protein kinase RIO2 (EC 2.7.11.1) (RIO kinase 2)

Gene: RIOK2
Organism: Homo sapiens
Interactions: 123
UniProt ID: Q9BVS4

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

970080

RS16
Small ribosomal subunit protein uS9

1

5

High-throughput

0.691

High

1179365

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

4

High-throughput

0.691

High

1118977

BYST
Bystin

4

4

Small-scale

0.691

High

1045718

TF65
Transcription factor p65

2

1

High-throughput

0.614

High

1349219

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

2

1

High-throughput

0.611

High

1415644

HECD1
E3 ubiquitin-protein ligase HECTD1

2

3

Small-scale

0.611

High

1126648

GRB7
Growth factor receptor-bound protein 7

2

1

High-throughput

0.571

High

997987

CSK21
Casein kinase II subunit alpha

1

8

High-throughput

0.550

High

1014602

SMAD3
Mothers against decapentaplegic homolog 3

1

1

High-throughput

0.541

High

1399345

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

1

High-throughput

0.541

High

123816

MYO1C
Unconventional myosin-Ic

1

3

High-throughput

0.536

High

277806

H2AY
Core histone macro-H2A.1

1

3

High-throughput

0.536

High

478191

SNRPA
U1 small nuclear ribonucleoprotein A

1

5

High-throughput

0.536

High

487708

PARP1
Poly [ADP-ribose] polymerase 1

1

3

High-throughput

0.536

High

502113

H2AZ
Histone H2A.Z

1

4

High-throughput

0.536

High

625594

CSK22
Casein kinase II subunit alpha'

1

8

High-throughput

0.536

High

859048

RL27A
Large ribosomal subunit protein uL15

1

1

High-throughput

0.536

High

922492

CLH2
Clathrin heavy chain 2

1

2

High-throughput

0.536

High

939422

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

4

High-throughput

0.536

High

969407

RS8
Small ribosomal subunit protein eS8

1

4

High-throughput

0.536

High

973290

RS13
Small ribosomal subunit protein uS15

1

3

High-throughput

0.536

High

973565

RS11
Small ribosomal subunit protein uS17

1

4

High-throughput

0.536

High

979193

RS6
Small ribosomal subunit protein eS6

1

4

High-throughput

0.536

High

1016373

SERF2
Small EDRK-rich factor 2

1

1

High-throughput

0.536

High

1027713

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

5

High-throughput

0.536

High

1033198

EWS
RNA-binding protein EWS

1

1

High-throughput

0.536

High

1094250

ACACA
Acetyl-CoA carboxylase 1

1

4

High-throughput

0.536

High

1101003

G3BP1
Ras GTPase-activating protein-binding protein 1

1

3

High-throughput

0.536

High

1121863

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

5

High-throughput

0.536

High

1154434

STK11
Serine/threonine-protein kinase STK11

1

1

High-throughput

0.536

High

1160742

DREB
Drebrin

1

1

High-throughput

0.536

High

1162886

H2A2C
Histone H2A type 2-C

1

1

High-throughput

0.536

High

1294643

CD20B
Cell division cycle protein 20 homolog B

1

3

High-throughput

0.536

High

1391556

LTV1
Protein LTV1 homolog

1

2

High-throughput

0.536

High

1402555

SRPK1
SRSF protein kinase 1

1

2

High-throughput

0.536

High

1413554

H2AJ
Histone H2A.J

1

1

High-throughput

0.536

High

1415625

NSRP1
Nuclear speckle splicing regulatory protein 1

1

2

High-throughput

0.536

High

1415633

ABCF3
ATP-binding cassette sub-family F member 3

1

2

High-throughput

0.536

High

1415642

ACINU
Apoptotic chromatin condensation inducer in the nucleus

1

2

High-throughput

0.536

High

1415645

ABT1
Activator of basal transcription 1

1

1

High-throughput

0.536

High

1415646

NOB1
RNA-binding protein NOB1

1

4

High-throughput

0.536

High

1415648

RTRAF
RNA transcription, translation and transport factor protein

1

1

High-throughput

0.536

High

1415649

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

1

High-throughput

0.536

High

1116190

FCL
GDP-L-fucose synthase

1

0

High-throughput

0.518

High

281780

VP26A
Vacuolar protein sorting-associated protein 26A

1

0

High-throughput

0.513

High

294887

BCAR3
Breast cancer anti-estrogen resistance protein 3

1

0

High-throughput

0.513

High

386180

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.513

High

480296

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

733757

FOXN2
Forkhead box protein N2

1

0

High-throughput

0.513

High

867391

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

948582

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.513

High

1200226

LBH
Protein LBH

1

0

High-throughput

0.513

High

1210521

HP1B3
Heterochromatin protein 1-binding protein 3

1

0

High-throughput

0.513

High

1213142

BEND3
BEN domain-containing protein 3

1

0

High-throughput

0.513

High

1234196

JADE1
Protein Jade-1

1

0

High-throughput

0.513

High

1254139

CAN12
Calpain-12

1

0

High-throughput

0.513

High

1326432

MINK1
Misshapen-like kinase 1

1

0

High-throughput

0.513

High

1364371

RT27
Small ribosomal subunit protein mS27

1

0

High-throughput

0.513

High

1399322

BIRC8
Baculoviral IAP repeat-containing protein 8

1

0

High-throughput

0.513

High

1400913

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.513

High

1415636

BCLF1
Bcl-2-associated transcription factor 1

1

0

High-throughput

0.513

High

1415640

RALY
RNA-binding protein Raly

1

0

High-throughput

0.513

High

1415641

FBX5
F-box only protein 5

1

0

High-throughput

0.513

High

1415643

NUP50
Nuclear pore complex protein Nup50

1

0

High-throughput

0.513

High

1415650

SPIN1
Spindlin-1

1

0

High-throughput

0.513

High

423055

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

1216310

MTCL3
Microtubule cross-linking factor 3

1

2

High-throughput

0.489

High

1413965

MMTA2
Multiple myeloma tumor-associated protein 2

1

1

High-throughput

0.489

High

173302

XPO1
Exportin-1

1

9

High-throughput

0.479

High

248341

HBP1
HMG box-containing protein 1

1

1

High-throughput

0.479

High

315968

RECQ4
ATP-dependent DNA helicase Q4

1

13

High-throughput

0.479

High

363805

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.479

High

373039

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

401417

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

639301

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

4

Small-scale

0.479

High

786817

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

2

High-throughput

0.479

High

839355

MTOR
Serine/threonine-protein kinase mTOR

1

7

Small-scale

0.479

High

872013

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

1

High-throughput

0.479

High

879428

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.479

High

942855

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

2

High-throughput

0.479

High

1024812

VIGLN
Vigilin

1

3

High-throughput

0.479

High

1091649

TAF10
Transcription initiation factor TFIID subunit 10

1

1

High-throughput

0.479

High

1095785

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

3

High-throughput

0.479

High

1106690

SMAD4
Mothers against decapentaplegic homolog 4

1

1

High-throughput

0.479

High

1132942

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

3

High-throughput

0.479

High

1138008

TNIP1
TNFAIP3-interacting protein 1

1

5

High-throughput

0.479

High

1138588

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

1208167

NKAPL
NKAP-like protein

1

1

High-throughput

0.479

High

1235511

IFIX
Pyrin and HIN domain-containing protein 1

1

1

High-throughput

0.479

High

1276732

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

1290958

TAXB1
Tax1-binding protein 1

1

3

High-throughput

0.479

High

1327652

NKAP
NF-kappa-B-activating protein

1

1

High-throughput

0.479

High

1334862

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

1415628

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.479

High

1415629

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

1415631

CPAP
Centrosomal P4.1-associated protein

1

2

High-throughput

0.479

High

1415634

TXN4B
Thioredoxin-like protein 4B

1

1

Small-scale

0.479

High

1415635

TBA8
Tubulin alpha-8 chain

1

3

High-throughput

0.479

High

1415637

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1415638

XPO7
Exportin-7

1

8

High-throughput

0.479

High

1415630

PRD16
Histone-lysine N-methyltransferase PRDM16

1

0

High-throughput

0.460

High

48771

ESYT2
Extended synaptotagmin-2

1

0

High-throughput

0.458

High

117627

IFNL4
Interferon lambda-4

1

0

High-throughput

0.458

High

242787

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

697427

DCK
Deoxycytidine kinase

1

0

High-throughput

0.458

High

1158511

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.458

High

1364038

RTF1
RNA polymerase-associated protein RTF1 homolog

1

0

High-throughput

0.458

High

47565

RPSA2
Small ribosomal subunit protein uS2B

1

7

High-throughput

0.445

High

1340194

ARK74
Aflatoxin B1 aldehyde reductase member 4

1

1

High-throughput

0.445

High

1415632

SLX9
Ribosome biogenesis protein SLX9 homolog

1

1

High-throughput

0.445

High

1327170

FBXL6
F-box/LRR-repeat protein 6

1

2

High-throughput

0.437

High

1415647

RL26L
Ribosomal protein uL24-like

1

4

High-throughput

0.437

High

1064018

ECHP
Peroxisomal bifunctional enzyme

1

0

High-throughput

0.426

High

1326069

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

1279025

TAFA3
Chemokine-like protein TAFA-3

2

0

High-throughput

0.328

High

320497

TM63A
Mechanosensitive cation channel TMEM63A

1

0

High-throughput

0.279

Low

415148

AMYP
Pancreatic alpha-amylase

1

0

High-throughput

0.279

Low

1415626

VPS16
Vacuolar protein sorting-associated protein 16 homolog

1

0

High-throughput

0.279

Low

1415627

GHITM
Growth hormone-inducible transmembrane protein

1

0

High-throughput

0.279

Low

1415639

STML2
Stomatin-like protein 2, mitochondrial

1

0

High-throughput

0.279

Low

1415651

SPCS1
Signal peptidase complex subunit 1

1

0

High-throughput

0.279

Low

280052

RM33
Large ribosomal subunit protein bL33m

1

0

High-throughput

0.249

Low

572380

CX7A2
Cytochrome c oxidase subunit 7A2, mitochondrial

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025