HitPredict

Interactor 1: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Interactor 2: BAP1 (Q92560)
Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6)
Gene: BAP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.639

Property	Details
Experiments	37655321, 9528852
Identification Methods	affinity chromatography technology, two hybrid, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005694 - chromosome GO:0005737 - cytoplasm GO:0045892 - negative regulation of DNA-templated transcription and 1 others more... GO:0051726 - regulation of cell cycle
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1863 Hs			1 729
+	Mm
		877631 BRCA1_MOUSE (1-1858): 0: 1394: 55.69		BAP1_MOUSE (1-729): 0: 1120: 93.14
+	Hs
		799614 BRCA1_HUMAN (1-1863): 0: 1570: 100.00		UCHL5_HUMAN (5-324): 6.72e-131: 392: 35.71
+	Hs
		623466 RO52_HUMAN (15-390): 5.97e-69: 243: 12.86		BAP1_HUMAN (1-729): 0: 1185: 100.00
+	Hs
		488527 TOPB1_HUMAN (1122-1861): 4.09e-150: 505: 14.12		UCHL1_HUMAN (7-236): 1.96e-69: 228: 22.27
+	Hs
		572299 TRI27_HUMAN (13-390): 6.01e-69: 244: 11.74		UCHL5_HUMAN (5-324): 6.72e-131: 392: 35.71
+	Hs
		571862 TRI27_HUMAN (13-390): 6.01e-69: 244: 11.74		UCHL3_HUMAN (2-236): 1.76e-78: 252: 23.05
+	Hs
		488402 RO52_HUMAN (15-390): 5.97e-69: 243: 12.86		UCHL1_HUMAN (7-236): 1.96e-69: 228: 22.27