Interactor 1: MK08 (P45983)
Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1)
Gene: MAPK8
Interactor 2: DUS10 (Q9Y6W6)
Dual specificity protein phosphatase 10 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 5) (MAP kinase phosphatase 5) (MKP-5)
Gene: DUSP10
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.86 | 1.00 | 0.932 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 10391943, 28675297, 32296183, 16166642, unassigned1304 |
| Identification Methods | two hybrid, affinity chromatography technology, enzymatic study, pull down, anti tag coimmunoprecipitation, two hybrid prey pooling approach, two hybrid array, validated two hybrid |
| Interaction Type | direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | DSPc~Pkinase, Pkinase~Rhodanese |
| Common GO terms | GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0051403 - stress-activated MAPK cascade |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
