HitPredict

Interactor 1: MP2K4 (P45985)
Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) (Stress-activated protein kinase kinase 1) (SAPK kinase 1) (SAPKK-1) (SAPKK1) (c-Jun N-terminal kinase kinase 1) (JNKK)
Gene: MAP2K4

Interactor 2: HSC20 (Q8IWL3)
Iron-sulfur cluster co-chaperone protein HscB (DnaJ homolog subfamily C member 20) [Cleaved into: Iron-sulfur cluster co-chaperone protein HscB, cytoplasmic (C-HSC20); Iron-sulfur cluster co-chaperone protein HscB, mitochondrial]
Gene: HSCB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	28380382
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 399 Hs			1 235
+	Hs
		805443 MP2K3_HUMAN (22-387): 5.5e-121: 356: 46.72		HSC20_HUMAN (1-235): 1.7e-133: 376: 100.00
+	Hs
		153146 MP2K7_HUMAN (48-394): 7.51e-113: 338: 45.87		HSC20_HUMAN (1-235): 1.7e-133: 376: 100.00
+	Hs
		1027399 STK3_HUMAN (68-386): 1.49e-102: 314: 31.25		HSC20_HUMAN (1-235): 1.7e-133: 376: 100.00
+	Hs
		1219162 STK24_HUMAN (72-387): 1.03e-99: 305: 32.81		HSC20_HUMAN (1-235): 1.7e-133: 376: 100.00
+	Hs
		131588 STK25_HUMAN (85-387): 5.86e-98: 300: 32.46		HSC20_HUMAN (1-235): 1.7e-133: 376: 100.00
+	Hs
		734973 MP2K2_HUMAN (100-393): 3.95e-62: 206: 37.24		HSC20_HUMAN (1-235): 1.7e-133: 376: 100.00
+	Hs
		972221 MP2K1_HUMAN (100-393): 1.72e-60: 202: 36.20		HSC20_HUMAN (1-235): 1.7e-133: 376: 100.00