Protein: RFC3
Replication factor C subunit 3 (Replication factor C3) (Activator 1 40 kDa subunit)

Gene: RFC3
Organism: Saccharomyces cerevisiae S288C
Interactions: 112
UniProt ID: P38629

Gene Ontology (top 5):
GO:0000077 - DNA damage checkpoint signaling
GO:0003677 - DNA binding
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005663 - DNA replication factor C complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

800952

RFC2
Replication factor C subunit 2

13

15

Small-scale

0.981

High

744193

RAD24
Checkpoint protein RAD24

8

20

Small-scale

0.970

High

800961

CTF18
Chromosome transmission fidelity protein 18

7

18

Small-scale

0.962

High

800950

RFC4
Replication factor C subunit 4

5

15

Small-scale

0.931

High

796693

RFC5
Replication factor C subunit 5

5

16

High-throughput

0.927

High

586453

PCNA
Proliferating cell nuclear antigen

4

16

Small-scale

0.896

High

800943

RFC1
Replication factor C subunit 1

3

18

High-throughput

0.855

High

800981

ELG1
Telomere length regulation protein ELG1

6

18

Small-scale

0.729

High

750834

PRS6B
26S proteasome regulatory subunit 6B homolog

1

2

High-throughput

0.691

High

419718

H2A2
Histone H2A.2

3

7

High-throughput

0.650

High

793819

DPOA2
DNA polymerase alpha subunit B

2

2

High-throughput

0.621

High

800945

CTF8
Chromosome transmission fidelity protein 8

2

3

Small-scale

0.621

High

726987

HS104
Heat shock protein 104

1

2

High-throughput

0.618

High

800951

ATAD2
ATPase histone chaperone YTA7

1

6

High-throughput

0.618

High

800987

RUVB2
RuvB-like protein 2

2

11

High-throughput

0.594

High

800986

SMT3
Ubiquitin-like protein SMT3

2

3

Small-scale

0.586

High

382073

H4
Histone H4

2

7

High-throughput

0.584

High

392662

HSP82
ATP-dependent molecular chaperone HSP82

2

6

High-throughput

0.584

High

594349

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

3

High-throughput

0.584

High

800954

DSN1
Kinetochore-associated protein DSN1

2

3

High-throughput

0.584

High

673097

RNQ1
[PIN+] prion protein RNQ1

1

1

High-throughput

0.536

High

721900

XPO1
Exportin-1

1

9

High-throughput

0.536

High

800956

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

3

High-throughput

0.536

High

800968

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

9

High-throughput

0.536

High

800973

YM71
NADP-dependent 3-hydroxy acid dehydrogenase

1

1

High-throughput

0.536

High

800957

ECO1
N-acetyltransferase ECO1

1

3

Small-scale

0.515

High

794870

MAP2
Methionine aminopeptidase 2

1

0

High-throughput

0.513

High

794964

NU170
Nucleoporin NUP170

1

3

High-throughput

0.504

High

367017

ATPB
ATP synthase subunit beta, mitochondrial

1

7

High-throughput

0.500

High

452900

ATPA
ATP synthase subunit alpha, mitochondrial

1

7

High-throughput

0.500

High

453572

PYR1
Multifunctional protein URA2

1

2

High-throughput

0.500

High

486157

TBA1
Tubulin alpha-1 chain

1

1

High-throughput

0.500

High

555069

G6PI
Glucose-6-phosphate isomerase

1

1

High-throughput

0.500

High

590616

HSP26
Heat shock protein 26

1

2

High-throughput

0.500

High

592223

VATB
V-type proton ATPase subunit B

1

7

High-throughput

0.500

High

599010

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

1

High-throughput

0.500

High

740153

RPN2
26S proteasome regulatory subunit RPN2

1

1

High-throughput

0.500

High

800959

TCPQ
T-complex protein 1 subunit theta

1

2

High-throughput

0.500

High

800988

CMR1
DNA damage-binding protein CMR1

1

5

High-throughput

0.481

High

368654

PMG1
Phosphoglycerate mutase 1

1

0

High-throughput

0.479

High

408573

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

0

High-throughput

0.479

High

800977

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

0

High-throughput

0.479

High

149730

RS9A
Small ribosomal subunit protein uS4A

1

3

High-throughput

0.479

High

381089

H2B1
Histone H2B.1

1

14

High-throughput

0.479

High

381505

H2B2
Histone H2B.2

1

14

High-throughput

0.479

High

383673

RS17A
Small ribosomal subunit protein eS17A

1

3

High-throughput

0.479

High

410099

RL25
Large ribosomal subunit protein uL23

1

3

High-throughput

0.479

High

416812

DNLI1
DNA ligase 1

1

3

Small-scale

0.479

High

432561

RL7A
Large ribosomal subunit protein uL30A

1

2

High-throughput

0.479

High

433611

RL26A
Large ribosomal subunit protein uL24A

1

6

High-throughput

0.479

High

435058

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.479

High

435932

RS13
Small ribosomal subunit protein uS15

1

3

High-throughput

0.479

High

441881

RS14A
Small ribosomal subunit protein uS11A

1

3

High-throughput

0.479

High

455033

RS19A
Small ribosomal subunit protein eS19A

1

4

High-throughput

0.479

High

488953

SWI6
Regulatory protein SWI6

1

3

High-throughput

0.479

High

503013

RS22A
Small ribosomal subunit protein uS8A

1

3

High-throughput

0.479

High

504183

RL31A
Large ribosomal subunit protein eL31A

1

3

High-throughput

0.479

High

512410

RS6A
Small ribosomal subunit protein eS6A

1

5

High-throughput

0.479

High

512979

RS8A
Small ribosomal subunit protein eS8A

1

5

High-throughput

0.479

High

514611

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.479

High

579318

HSC82
ATP-dependent molecular chaperone HSC82

1

6

High-throughput

0.479

High

642036

DPOE
DNA polymerase epsilon catalytic subunit A

1

1

High-throughput

0.479

High

670652

SIS1
Protein SIS1

1

3

High-throughput

0.479

High

674592

RS2
Small ribosomal subunit protein uS5

1

3

High-throughput

0.479

High

676832

DCC1
Sister chromatid cohesion protein DCC1

1

7

High-throughput

0.479

High

689423

RS7A
Small ribosomal subunit protein eS7A

1

3

High-throughput

0.479

High

706980

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.479

High

734955

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

3

High-throughput

0.479

High

736641

ASF1
Histone chaperone ASF1

1

3

Small-scale

0.479

High

745720

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

3

High-throughput

0.479

High

747331

RSSA1
Small ribosomal subunit protein uS2A

1

4

High-throughput

0.479

High

753341

RS3A1
Small ribosomal subunit protein eS1A

1

3

High-throughput

0.479

High

779218

CENPA
Histone H3-like centromeric protein CSE4

1

13

High-throughput

0.479

High

792015

GBLP
Small ribosomal subunit protein RACK1

1

6

High-throughput

0.479

High

800944

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.479

High

800947

LAA1
AP-1 accessory protein LAA1

1

3

High-throughput

0.479

High

800953

ULP2
Ubiquitin-like-specific protease 2

1

3

High-throughput

0.479

High

800960

RS12
Small ribosomal subunit protein eS12

1

3

High-throughput

0.479

High

800963

RL26B
Large ribosomal subunit protein uL24B

1

6

High-throughput

0.479

High

800964

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

9

Small-scale

0.479

High

800966

H3
Histone H3

1

13

High-throughput

0.479

High

800967

CTF4
DNA polymerase alpha-binding protein

1

6

Small-scale

0.479

High

800969

RS15
Small ribosomal subunit protein uS19

1

3

High-throughput

0.479

High

800971

RUVB1
RuvB-like protein 1

1

11

High-throughput

0.479

High

800972

SIZ1
E3 SUMO-protein ligase SIZ1

1

2

High-throughput

0.479

High

800974

HRQ1
ATP-dependent helicase HRQ1

1

6

Small-scale

0.479

High

800975

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

2

High-throughput

0.479

High

800978

SGO1
Shugoshin

1

3

High-throughput

0.479

High

800979

RS10A
Small ribosomal subunit protein eS10A

1

3

High-throughput

0.479

High

800982

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

2

High-throughput

0.479

High

800983

SCC1
Sister chromatid cohesion protein 1

1

4

High-throughput

0.479

High

800985

SIZ2
E3 SUMO-protein ligase SIZ2

1

2

High-throughput

0.479

High

569994

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.458

High

800962

UBC9
SUMO-conjugating enzyme UBC9

1

0

High-throughput

0.458

High

800980

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

800984

YRA1
RNA annealing protein YRA1

1

0

High-throughput

0.458

High

386693

TBB
Tubulin beta chain

1

1

High-throughput

0.457

High

800958

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

1

2

High-throughput

0.457

High

481606

HSP73
Heat shock protein SSA3

1

5

High-throughput

0.445

High

544715

SSB1
Ribosome-associated molecular chaperone SSB1

1

8

High-throughput

0.445

High

675969

MAS5
Mitochondrial protein import protein MAS5

1

4

High-throughput

0.445

High

800948

HSP7E
Heat shock protein SSC3, mitochondrial

1

2

High-throughput

0.445

High

800949

SSB2
Ribosome-associated molecular chaperone SSB2

1

8

High-throughput

0.445

High

800965

APJ1
J domain-containing protein APJ1

1

3

High-throughput

0.445

High

800970

UBC7
Ubiquitin-conjugating enzyme E2 7

1

0

High-throughput

0.438

High

748372

SC61A
Protein transport protein SEC61

1

1

High-throughput

0.437

High

800976

VAM6
Vacuolar morphogenesis protein 6

1

3

High-throughput

0.437

High

575586

PP2B2
Serine/threonine-protein phosphatase 2B catalytic subunit A2

1

0

High-throughput

0.279

Low

677058

YCE2
Putative uncharacterized protein YCL042W

1

0

High-throughput

0.279

Low

790194

GLYC
Serine hydroxymethyltransferase, cytosolic

1

0

High-throughput

0.279

Low

800955

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.249

Low

800946

MNN9
Mannan polymerase complexes subunit MNN9

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025