Protein: RFC2
Replication factor C subunit 2 (Replication factor C2) (Activator 1 41 kDa subunit)

Gene: RFC2
Organism: Saccharomyces cerevisiae S288C
Interactions: 113
UniProt ID: P40348

Gene Ontology (top 5):
GO:0000076 - DNA replication checkpoint signaling
GO:0000077 - DNA damage checkpoint signaling
GO:0003677 - DNA binding
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

800952

RFC3
Replication factor C subunit 3

13

15

Small-scale

0.981

High

744201

RAD24
Checkpoint protein RAD24

8

20

Small-scale

0.971

High

796704

RFC5
Replication factor C subunit 5

9

17

Small-scale

0.968

High

822950

RFC4
Replication factor C subunit 4

8

16

Small-scale

0.960

High

800996

RFC1
Replication factor C subunit 1

7

20

Small-scale

0.949

High

586466

PCNA
Proliferating cell nuclear antigen

5

16

Small-scale

0.924

High

823128

CTF18
Chromosome transmission fidelity protein 18

5

17

Small-scale

0.916

High

823149

ELG1
Telomere length regulation protein ELG1

8

17

Small-scale

0.748

High

806427

CTF8
Chromosome transmission fidelity protein 8

2

3

Small-scale

0.621

High

822985

ATAD2
ATPase histone chaperone YTA7

1

6

High-throughput

0.618

High

382138

H4
Histone H4

2

7

High-throughput

0.584

High

419759

H2A2
Histone H2A.2

2

7

High-throughput

0.584

High

823120

DSN1
Kinetochore-associated protein DSN1

2

3

High-throughput

0.584

High

823126

TCPQ
T-complex protein 1 subunit theta

2

2

High-throughput

0.584

High

526847

HSP72
Heat shock protein SSA2

2

5

High-throughput

0.552

High

818908

SSB2
Ribosome-associated molecular chaperone SSB2

2

8

High-throughput

0.552

High

399370

CARB
Carbamoyl phosphate synthase arginine-specific large chain

1

2

High-throughput

0.536

High

452511

PUR2
Bifunctional purine biosynthetic protein ADE5,7 [Includes: Phosphoribosylamine--glycine ligase

1

1

High-throughput

0.536

High

721994

XPO1
Exportin-1

1

9

High-throughput

0.536

High

744122

BRR2
Pre-mRNA-splicing helicase BRR2

1

4

High-throughput

0.536

High

823141

IMA1
Importin subunit alpha

1

1

High-throughput

0.536

High

747404

RSSA1
Small ribosomal subunit protein uS2A

2

4

High-throughput

0.521

High

753406

RS3A1
Small ribosomal subunit protein eS1A

2

3

High-throughput

0.521

High

823121

ECO1
N-acetyltransferase ECO1

1

3

Small-scale

0.515

High

726012

NTH1
Endonuclease III homolog 1

1

0

High-throughput

0.513

High

823130

ROM2
RHO1 GDP-GTP exchange protein 2

1

0

High-throughput

0.513

High

823136

EF3B
Elongation factor 3B

1

0

High-throughput

0.513

High

795018

NU170
Nucleoporin NUP170

1

3

High-throughput

0.504

High

796770

MMS4
Crossover junction endonuclease MMS4

1

1

Small-scale

0.501

High

823143

MUS81
Crossover junction endonuclease MUS81

1

1

Small-scale

0.501

High

367043

ATPB
ATP synthase subunit beta, mitochondrial

1

7

High-throughput

0.500

High

531336

METK1
S-adenosylmethionine synthase 1

1

1

High-throughput

0.500

High

621375

METK2
S-adenosylmethionine synthase 2

1

1

High-throughput

0.500

High

676049

MAS5
Mitochondrial protein import protein MAS5

1

4

High-throughput

0.500

High

709796

BMH1
Protein BMH1

1

1

High-throughput

0.500

High

817870

IMB4
Importin subunit beta-4

1

3

High-throughput

0.500

High

815969

VAC8
Vacuolar protein 8

1

2

High-throughput

0.489

High

823122

RSSA2
Small ribosomal subunit protein uS2B

1

4

High-throughput

0.489

High

823129

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

1

High-throughput

0.489

High

823125

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.486

High

823154

CMR1
DNA damage-binding protein CMR1

1

5

High-throughput

0.481

High

381125

H2B1
Histone H2B.1

1

14

High-throughput

0.479

High

381532

H2B2
Histone H2B.2

1

14

High-throughput

0.479

High

416818

DNLI1
DNA ligase 1

1

3

Small-scale

0.479

High

435133

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.479

High

448974

TOP2
DNA topoisomerase 2

1

1

High-throughput

0.479

High

579505

HSC82
ATP-dependent molecular chaperone HSC82

1

6

High-throughput

0.479

High

594402

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

High-throughput

0.479

High

676841

DCC1
Sister chromatid cohesion protein DCC1

1

7

High-throughput

0.479

High

707266

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.479

High

735008

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

3

High-throughput

0.479

High

736656

ASF1
Histone chaperone ASF1

1

3

Small-scale

0.479

High

745765

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

3

High-throughput

0.479

High

823133

HST2
NAD-dependent protein deacetylase HST2

1

2

High-throughput

0.479

High

823135

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

9

Small-scale

0.479

High

823138

H3
Histone H3

1

13

High-throughput

0.479

High

823139

CTF4
DNA polymerase alpha-binding protein

1

5

Small-scale

0.479

High

823142

RUVB1
RuvB-like protein 1

1

11

High-throughput

0.479

High

823147

SGO1
Shugoshin

1

3

High-throughput

0.479

High

823150

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

2

High-throughput

0.479

High

823151

SCC1
Sister chromatid cohesion protein 1

1

4

High-throughput

0.479

High

823153

RUVB2
RuvB-like protein 2

1

11

High-throughput

0.479

High

823144

IVY1
Protein IVY1

1

1

High-throughput

0.464

High

823145

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

425130

OTC
Ornithine carbamoyltransferase

1

2

High-throughput

0.457

High

823137

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

2

High-throughput

0.457

High

392827

HSP82
ATP-dependent molecular chaperone HSP82

1

6

High-throughput

0.445

High

510544

HSP77
Import motor subunit, mitochondrial

1

2

High-throughput

0.445

High

524131

HSP71
Heat shock protein SSA1

1

5

High-throughput

0.445

High

545093

SSB1
Ribosome-associated molecular chaperone SSB1

1

8

High-throughput

0.445

High

741694

HSP7F
Heat shock protein homolog SSE1

1

6

High-throughput

0.445

High

776473

MPE1
Protein MPE1

1

0

High-throughput

0.438

High

149800

RS9A
Small ribosomal subunit protein uS4A

1

3

High-throughput

0.437

High

383734

RS17A
Small ribosomal subunit protein eS17A

1

3

High-throughput

0.437

High

410170

RL25
Large ribosomal subunit protein uL23

1

3

High-throughput

0.437

High

433678

RL26A
Large ribosomal subunit protein uL24A

1

6

High-throughput

0.437

High

436000

RS13
Small ribosomal subunit protein uS15

1

3

High-throughput

0.437

High

441944

RS14A
Small ribosomal subunit protein uS11A

1

3

High-throughput

0.437

High

455100

RS19A
Small ribosomal subunit protein eS19A

1

4

High-throughput

0.437

High

503078

RS22A
Small ribosomal subunit protein uS8A

1

3

High-throughput

0.437

High

504247

RL31A
Large ribosomal subunit protein eL31A

1

3

High-throughput

0.437

High

512475

RS6A
Small ribosomal subunit protein eS6A

1

5

High-throughput

0.437

High

513042

RS8A
Small ribosomal subunit protein eS8A

1

5

High-throughput

0.437

High

514668

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.437

High

674662

RS2
Small ribosomal subunit protein uS5

1

3

High-throughput

0.437

High

689492

RS7A
Small ribosomal subunit protein eS7A

1

3

High-throughput

0.437

High

748422

SC61A
Protein transport protein SEC61

1

1

High-throughput

0.437

High

778363

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.437

High

802208

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.437

High

804845

NMD2
Nonsense-mediated mRNA decay protein 2

1

1

Small-scale

0.437

High

812361

LAA1
AP-1 accessory protein LAA1

1

3

High-throughput

0.437

High

823127

RS12
Small ribosomal subunit protein eS12

1

3

High-throughput

0.437

High

823131

RL26B
Large ribosomal subunit protein uL24B

1

6

High-throughput

0.437

High

823134

GIS2
Zinc finger protein GIS2

1

1

High-throughput

0.437

High

823140

RS15
Small ribosomal subunit protein uS19

1

3

High-throughput

0.437

High

823146

VAM6
Vacuolar morphogenesis protein 6

1

3

High-throughput

0.437

High

823148

RS10A
Small ribosomal subunit protein eS10A

1

3

High-throughput

0.437

High

432604

RL7A
Large ribosomal subunit protein uL30A

1

2

High-throughput

0.407

High

433222

RL17A
Large ribosomal subunit protein uL22A

1

1

High-throughput

0.407

High

655468

RS3A2
Small ribosomal subunit protein eS1B

1

3

High-throughput

0.407

High

712586

RL8B
Large ribosomal subunit protein eL8B

1

1

High-throughput

0.407

High

823123

RL17B
Large ribosomal subunit protein uL22B

1

1

High-throughput

0.407

High

823152

RL7B
Large ribosomal subunit protein uL30B

1

2

High-throughput

0.407

High

644630

MDHC
Malate dehydrogenase, cytoplasmic

1

0

High-throughput

0.279

Low

733772

ACH1
Acetyl-CoA hydrolase

1

0

High-throughput

0.279

Low

788418

PGM2
Phosphoglucomutase 2

1

0

High-throughput

0.279

Low

793083

ATPG
ATP synthase subunit gamma, mitochondrial

1

0

High-throughput

0.279

Low

585557

BGL2
Glucan 1,3-beta-glucosidase

1

0

High-throughput

0.261

Low

823119

MPM1
Mitochondrial peculiar membrane protein 1

1

0

High-throughput

0.261

Low

558751

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.249

Low

780607

CAB3
Coenzyme A biosynthesis protein 3

1

0

High-throughput

0.238

Low

823124

MRX5
MIOREX complex component 5

1

0

High-throughput

0.238

Low

823132

TAM41
Phosphatidate cytidylyltransferase, mitochondrial

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025