Protein: RFC4
Replication factor C subunit 4 (Replication factor C4) (Activator 1 37 kDa subunit)

Gene: RFC4
Organism: Saccharomyces cerevisiae S288C
Interactions: 111
UniProt ID: P40339

Gene Ontology (top 5):
GO:0000077 - DNA damage checkpoint signaling
GO:0003677 - DNA binding
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005663 - DNA replication factor C complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

822959

CTF18
Chromosome transmission fidelity protein 18

8

19

Small-scale

0.966

High

822950

RFC2
Replication factor C subunit 2

8

16

Small-scale

0.960

High

744200

RAD24
Checkpoint protein RAD24

6

20

Small-scale

0.938

High

800950

RFC3
Replication factor C subunit 3

5

15

Small-scale

0.931

High

586465

PCNA
Proliferating cell nuclear antigen

4

17

Small-scale

0.896

High

796703

RFC5
Replication factor C subunit 5

3

18

High-throughput

0.855

High

800994

RFC1
Replication factor C subunit 1

3

20

High-throughput

0.855

High

822979

ELG1
Telomere length regulation protein ELG1

10

19

Small-scale

0.755

High

727077

HS104
Heat shock protein 104

1

3

High-throughput

0.691

High

750849

PRS6B
26S proteasome regulatory subunit 6B homolog

1

2

High-throughput

0.691

High

679754

CDC48
Cell division control protein 48

1

3

High-throughput

0.646

High

793826

DPOA2
DNA polymerase alpha subunit B

2

3

High-throughput

0.621

High

806426

CTF8
Chromosome transmission fidelity protein 8

2

3

Small-scale

0.621

High

752328

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.618

High

822969

PRS8
26S proteasome regulatory subunit 8 homolog

1

0

High-throughput

0.613

High

419757

H2A2
Histone H2A.2

2

8

High-throughput

0.611

High

452510

PUR2
Bifunctional purine biosynthetic protein ADE5,7 [Includes: Phosphoribosylamine--glycine ligase

1

1

High-throughput

0.536

High

673106

RNQ1
[PIN+] prion protein RNQ1

1

1

High-throughput

0.536

High

721993

XPO1
Exportin-1

1

10

High-throughput

0.536

High

822955

ECO1
N-acetyltransferase ECO1

1

4

Small-scale

0.515

High

622371

ACON
Aconitate hydratase, mitochondrial

1

0

High-throughput

0.513

High

649226

SAN1
Protein SAN1

1

0

High-throughput

0.513

High

802632

YHI0
Putative proline--tRNA ligase YHR020W

1

0

High-throughput

0.513

High

822956

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

0

High-throughput

0.513

High

822978

DDC1
DNA damage checkpoint protein 1

1

0

High-throughput

0.513

High

822982

AHA1
Hsp90 co-chaperone AHA1

1

0

High-throughput

0.513

High

795017

NU170
Nucleoporin NUP170

1

4

High-throughput

0.504

High

796769

MMS4
Crossover junction endonuclease MMS4

1

1

Small-scale

0.501

High

822971

MUS81
Crossover junction endonuclease MUS81

1

1

Small-scale

0.501

High

367042

ATPB
ATP synthase subunit beta, mitochondrial

1

7

High-throughput

0.500

High

392823

HSP82
ATP-dependent molecular chaperone HSP82

1

7

High-throughput

0.500

High

452916

ATPA
ATP synthase subunit alpha, mitochondrial

1

7

High-throughput

0.500

High

597153

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.500

High

599032

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

1

High-throughput

0.500

High

740173

RPN2
26S proteasome regulatory subunit RPN2

1

1

High-throughput

0.500

High

822957

TCPQ
T-complex protein 1 subunit theta

1

2

High-throughput

0.500

High

822964

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

2

High-throughput

0.500

High

822965

ACT
Actin

1

1

High-throughput

0.500

High

405099

LEU3
3-isopropylmalate dehydrogenase

1

0

High-throughput

0.479

High

607767

HXKG
Glucokinase-1

1

0

High-throughput

0.479

High

626761

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.479

High

149799

RS9A
Small ribosomal subunit protein uS4A

1

4

High-throughput

0.479

High

381123

H2B1
Histone H2B.1

1

16

High-throughput

0.479

High

822952

ULP2
Ubiquitin-like-specific protease 2

1

4

High-throughput

0.479

High

822953

DSN1
Kinetochore-associated protein DSN1

1

4

High-throughput

0.479

High

381530

H2B2
Histone H2B.2

1

16

High-throughput

0.479

High

382136

H4
Histone H4

1

8

High-throughput

0.479

High

383733

RS17A
Small ribosomal subunit protein eS17A

1

4

High-throughput

0.479

High

410169

RL25
Large ribosomal subunit protein uL23

1

4

High-throughput

0.479

High

416817

DNLI1
DNA ligase 1

1

4

Small-scale

0.479

High

433677

RL26A
Large ribosomal subunit protein uL24A

1

8

High-throughput

0.479

High

435132

RS3
Small ribosomal subunit protein uS3

1

4

High-throughput

0.479

High

435999

RS13
Small ribosomal subunit protein uS15

1

4

High-throughput

0.479

High

441943

RS14A
Small ribosomal subunit protein uS11A

1

4

High-throughput

0.479

High

455099

RS19A
Small ribosomal subunit protein eS19A

1

5

High-throughput

0.479

High

488960

SWI6
Regulatory protein SWI6

1

3

High-throughput

0.479

High

503077

RS22A
Small ribosomal subunit protein uS8A

1

4

High-throughput

0.479

High

504246

RL31A
Large ribosomal subunit protein eL31A

1

4

High-throughput

0.479

High

512474

RS6A
Small ribosomal subunit protein eS6A

1

6

High-throughput

0.479

High

513041

RS8A
Small ribosomal subunit protein eS8A

1

6

High-throughput

0.479

High

579500

HSC82
ATP-dependent molecular chaperone HSC82

1

7

High-throughput

0.479

High

594400

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

4

High-throughput

0.479

High

674661

RS2
Small ribosomal subunit protein uS5

1

4

High-throughput

0.479

High

676840

DCC1
Sister chromatid cohesion protein DCC1

1

8

High-throughput

0.479

High

689491

RS7A
Small ribosomal subunit protein eS7A

1

4

High-throughput

0.479

High

707261

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

712993

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.479

High

721377

MCM4
DNA replication licensing factor MCM4

1

2

Small-scale

0.479

High

735006

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

4

High-throughput

0.479

High

736655

ASF1
Histone chaperone ASF1

1

4

Small-scale

0.479

High

745763

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

4

High-throughput

0.479

High

747403

RSSA1
Small ribosomal subunit protein uS2A

1

6

High-throughput

0.479

High

753405

RS3A1
Small ribosomal subunit protein eS1A

1

4

High-throughput

0.479

High

778362

RS27A
Small ribosomal subunit protein eS27A

1

3

High-throughput

0.479

High

802207

RS20
Small ribosomal subunit protein uS10

1

4

High-throughput

0.479

High

812360

LAA1
AP-1 accessory protein LAA1

1

4

High-throughput

0.479

High

822958

RS12
Small ribosomal subunit protein eS12

1

4

High-throughput

0.479

High

822962

RL26B
Large ribosomal subunit protein uL24B

1

8

High-throughput

0.479

High

822963

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

10

Small-scale

0.479

High

822966

H3
Histone H3

1

14

High-throughput

0.479

High

822967

CTF4
DNA polymerase alpha-binding protein

1

5

Small-scale

0.479

High

822968

RS15
Small ribosomal subunit protein uS19

1

4

High-throughput

0.479

High

822970

RUVB1
RuvB-like protein 1

1

11

High-throughput

0.479

High

822972

SIZ1
E3 SUMO-protein ligase SIZ1

1

4

High-throughput

0.479

High

822973

HRQ1
ATP-dependent helicase HRQ1

1

7

Small-scale

0.479

High

822974

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

2

High-throughput

0.479

High

822976

SGO1
Shugoshin

1

4

High-throughput

0.479

High

822977

RS10A
Small ribosomal subunit protein eS10A

1

4

High-throughput

0.479

High

822980

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

2

High-throughput

0.479

High

822981

SCC1
Sister chromatid cohesion protein 1

1

4

High-throughput

0.479

High

822983

RUVB2
RuvB-like protein 2

1

11

High-throughput

0.479

High

668272

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

0

High-throughput

0.458

High

674413

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

0

High-throughput

0.458

High

781938

KAE1
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.458

High

793574

TBS1
Uncharacterized transcriptional regulatory protein TBS1

1

0

High-throughput

0.458

High

822951

SPO22
Sporulation-specific protein 22

1

0

Small-scale

0.458

High

822954

BNI1
Protein BNI1

1

0

High-throughput

0.458

High

671646

SCJ1
DnaJ-related protein SCJ1

1

2

High-throughput

0.457

High

394614

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.445

High

453629

PYR1
Multifunctional protein URA2

1

2

High-throughput

0.445

High

486201

TBA1
Tubulin alpha-1 chain

1

1

High-throughput

0.445

High

592287

VATB
V-type proton ATPase subunit B

1

7

High-throughput

0.445

High

818905

SSB2
Ribosome-associated molecular chaperone SSB2

1

10

High-throughput

0.445

High

792824

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.438

High

822975

VAM6
Vacuolar morphogenesis protein 6

1

4

High-throughput

0.437

High

653866

HSP12
12 kDa heat shock protein

1

0

High-throughput

0.426

High

386731

TBB
Tubulin beta chain

1

1

High-throughput

0.407

High

822960

IMDH4
Inosine-5'-monophosphate dehydrogenase 4

1

2

High-throughput

0.407

High

358409

ADH2
Alcohol dehydrogenase 2

1

0

High-throughput

0.279

Low

822961

YGI1
Uncharacterized protein YGL081W

1

0

High-throughput

0.279

Low

484768

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.261

Low


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Last updated: 11Aug2025