HitPredict

Interactor 1: KI67 (P46013)
Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67)
Gene: MKI67

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	21182203
Identification Methods	cosedimentation through density gradient
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 3256 Hs			1 530
+	Hs
		369148 KI67_HUMAN (1-3256): 0: 1046: 100.00		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		622772 KI67_HUMAN (1-3256): 0: 1046: 100.00		COT2_HUMAN (77-502): 2.24e-102: 316: 23.90
+	Hs
		1056909 MDC1_HUMAN (20-1865): 6.71e-101: 366: 9.14		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369607 MDC1_HUMAN (20-1865): 6.71e-101: 366: 9.14		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		377537 MUC16_HUMAN (48-2581): 3.63e-63: 244: 8.34		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		1244235 BD1L1_HUMAN (98-2862): 2.37e-19: 99.1: 9.63		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1269948 SRRM2_HUMAN (1748-3241): 1.64e-18: 96: 8.53		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1264774 TITIN_HUMAN (52-1221): 1.55e-13: 80: 7.85		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1154059 NIPBL_HUMAN (2321-3191): 7.29e-12: 74.4: 12.83		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1187996 TICRR_HUMAN (2333-3150): 2.5e-11: 72.4: 13.37		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1270066 PCLO_HUMAN (78-1640): 1.72e-10: 69.6: 6.73		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369171 PRC2A_HUMAN (513-2601): 5.1e-21: 104: 7.93		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		487431 MDC1_HUMAN (20-1865): 6.71e-101: 366: 9.14		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		370728 SRRM2_HUMAN (1748-3241): 1.64e-18: 96: 8.53		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		370105 TITIN_HUMAN (52-1221): 1.55e-13: 80: 7.85		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		369815 NIPBL_HUMAN (2321-3191): 7.29e-12: 74.4: 12.83		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		377539 TITIN_HUMAN (52-1221): 1.55e-13: 80: 7.85		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		782571 NIPBL_HUMAN (2321-3191): 7.29e-12: 74.4: 12.83		HNF4A_HUMAN (94-502): 1.21e-107: 331: 23.30
+	Hs
		377401 NIPBL_HUMAN (2321-3191): 7.29e-12: 74.4: 12.83		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		487522 NIPBL_HUMAN (2321-3191): 7.29e-12: 74.4: 12.83		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59