HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: GAB1 (Q13480)
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Gene: GAB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	24728074, 19380743
Identification Methods	pull down, affinity chromatography technology, fluorescence polarization spectroscopy
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction GO:0035591 - signaling adaptor activity GO:0035728 - response to hepatocyte growth factor
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 304 Hs			1 694
+	Hs
		802837 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		548703 VAV_HUMAN (11-189): 6.6e-47: 170: 28.21		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Mm
		1246955 Q8R5B8_MOUSE (2-114): 3.18e-43: 145: 65.49		GAB1_MOUSE (1-694): 0: 544: 89.93
+	Hs
		1035413 VAV3_HUMAN (11-189): 1.56e-33: 131: 26.15		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		802781 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01
+	Hs
		275195 GRAP2_HUMAN (1-296): 5.17e-33: 125: 17.17		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		855792 VAV2_HUMAN (2-191): 3.44e-29: 119: 19.74		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		581001 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Mm
		1143296 PLCG1_MOUSE (2-302): 1.1e-26: 112: 15.43		GAB1_MOUSE (1-694): 0: 544: 89.93
+	Hs
		562645 PLCG2_HUMAN (1-301): 1.03e-25: 109: 15.89		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		802920 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01
+	Mm
		1141170 GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67		GAB1_MOUSE (1-694): 0: 544: 89.93
+	Hs
		275242 GRAP2_HUMAN (1-296): 5.17e-33: 125: 17.17		GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01
+	Hs
		581081 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01
+	Hs
		562669 PLCG2_HUMAN (1-301): 1.03e-25: 109: 15.89		GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01
+	Mm
		69824 B1AT92_MOUSE (135-297): 3.98e-27: 106: 15.39		GAB2_MOUSE (3-691): 8.7e-141: 429: 38.33
+	Mm
		1114082 GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67		Q3ZB59_MOUSE (3-691): 1.2e-140: 428: 38.33
+	Hs
		802856 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		PKHA7_HUMAN (5-485): 5.86e-74: 260: 12.07
+	Hs
		1153260 DNMBP_HUMAN (119-293): 5.7e-46: 168: 29.35		PKHA7_HUMAN (5-485): 5.86e-74: 260: 12.07
+	Hs
		802907 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49