HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: TRI25 (Q14258)
E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147)
Gene: TRIM25

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	35044719
Identification Methods	unspecified method, phage display
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 304 Hs			1 630
+	Hs
		802633 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73
+	Hs
		802841 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		TRI14_HUMAN (155-624): 1.74e-75: 249: 18.45
+	Hs
		802862 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73
+	Hs
		1167807 DNMBP_HUMAN (119-293): 5.7e-46: 168: 29.35		TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73
+	Hs
		1172216 VAV3_HUMAN (11-189): 1.56e-33: 131: 26.15		TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73
+	Hs
		581005 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		TRI14_HUMAN (155-624): 1.74e-75: 249: 18.45
+	Hs
		855804 VAV2_HUMAN (2-191): 3.44e-29: 119: 19.74		TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73
+	Hs
		581017 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73
+	Hs
		802736 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		TRI39_HUMAN (4-351): 6.55e-31: 128: 17.40
+	Hs
		924655 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73
+	Hs
		209130 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		TRI41_HUMAN (197-628): 1.4e-79: 266: 16.70
+	Hs
		1318359 CD2AP_HUMAN (1-196): 4.74e-12: 68.3: 17.12		TRIM8_HUMAN (7-358): 1.75e-77: 258: 25.21
+	Hs
		1172445 CD2AP_HUMAN (1-196): 4.74e-12: 68.3: 17.12		TRI67_HUMAN (48-591): 3.42e-69: 241: 15.73
+	Hs
		802723 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		TRI15_HUMAN (93-433): 4.45e-10: 64.3: 13.70
+	Hs
		275202 GRAP2_HUMAN (1-296): 5.17e-33: 125: 17.17		TRI68_HUMAN (2-449): 3.97e-31: 128: 13.94
+	Mm
		1143604 PLCG2_MOUSE (11-301): 1.34e-25: 108: 16.40		TRI27_MOUSE (2-358): 4.29e-31: 129: 14.95
+	Hs
		536781 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		TRI27_HUMAN (2-358): 2.11e-31: 130: 14.40
+	Hs
		924879 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		TRI39_HUMAN (4-351): 6.55e-31: 128: 17.40
+	Hs
		208986 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		TRI27_HUMAN (2-358): 2.11e-31: 130: 14.40
+	Hs
		584954 GRAP_HUMAN (135-294): 3.79e-21: 91.4: 16.67		RO52_HUMAN (72-325): 5.42e-14: 76.6: 13.36