HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: DOCK3 (Q8IZD9)
Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP)
Gene: DOCK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~SH3_2, SH3_1~SH3_2, DOCK_N~SH3_2, SH3_2~SH3_2
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0017124 - SH3 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 304 Hs			1 2030
+	Hs
		924695 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		DOCK3_HUMAN (1-2030): 0: 2302: 100.00
+	Hs
		557736 NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00		DOCK3_HUMAN (1-2030): 0: 2302: 100.00
+	Hs
		802881 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		DOCK2_HUMAN (2-1771): 0: 1932: 36.29
+	Hs
		924698 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		DOCK4_HUMAN (1-1996): 0: 2003: 54.58
+	Hs
		548738 VAV_HUMAN (11-189): 6.6e-47: 170: 28.21		DOCK2_HUMAN (2-1771): 0: 1932: 36.29
+	Hs
		802596 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		DOCK1_HUMAN (2-1861): 0: 1887: 36.96
+	Hs
		802842 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		DOCK1_HUMAN (2-1861): 0: 1887: 36.96
+	Hs
		1078864 ITSN1_HUMAN (150-302): 3.02e-10: 63.3: 13.87		DOCK4_HUMAN (1-1996): 0: 2003: 54.58
+	Hs
		802731 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		DOCK5_HUMAN (2-1851): 0: 1803: 34.82
+	Mm
		1141146 GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67		DOCK1_MOUSE (2-1855): 0: 1914: 37.08
+	Hs
		802906 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		DOCK5_HUMAN (2-1851): 0: 1803: 34.82
+	Hs
		924565 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		DOCK1_HUMAN (2-1861): 0: 1887: 36.96
+	Hs
		209053 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		DOCK1_HUMAN (2-1861): 0: 1887: 36.96
+	Hs
		557689 NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00		DOCK1_HUMAN (2-1861): 0: 1887: 36.96
+	Dm
		1362940 CRK_DROME (5-302): 8.8e-52: 173: 43.14		Q9VCH4_DROME (5-1851): 0: 1740: 30.96
+	Hs
		924868 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		DOCK5_HUMAN (2-1851): 0: 1803: 34.82
+	Ce
		107035 CED2_CAEEL (4-293): 3.24e-36: 133: 27.80		G5EEN3_CAEEL (10-1702): 0: 1350: 24.57
+	Dm
		1228832 CRK_DROME (5-302): 8.8e-52: 173: 43.14		Q8MQW7_DROME (654-1851): 0: 1037: 29.75
+	Mm
		292687 GRAP2_MOUSE (18-192): 6.73e-14: 72.9: 19.79		PTN23_MOUSE (1607-2027): 1.16e-10: 69.5: 12.07
+	Hs
		1056926 SH3K1_HUMAN (114-192): 4.08e-10: 62.5: 22.22		MDC1_HUMAN (1565-2030): 9.19e-14: 79.5: 11.16