Protein: SYEP
Bifunctional glutamate/proline--tRNA ligase (Bifunctional aminoacyl-tRNA synthetase) [Includes: Glutamate--tRNA ligase (EC 6.1.1.17) (Glutamyl-tRNA synthetase); Proline--tRNA ligase (EC 6.1.1.15) (Prolyl-tRNA synthetase) (ProRS)]

Gene: SYEP, GluProRS
Organism: Drosophila melanogaster
Interactions: 111
UniProt ID: P28668

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0004818 - glutamate-tRNA ligase activity
GO:0004827 - proline-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

704424

SYQ
Probable glutamine--tRNA ligase

2

7

High-throughput

0.737

High

704359

TERA
Transitional endoplasmic reticulum ATPase TER94

3

6

High-throughput

0.646

High

704400

Q9VMW2
Reticulon-like protein

3

1

High-throughput

0.642

High

704399

Q9VMV9
Reticulon-like protein

3

1

High-throughput

0.627

High

704403

Q9VQL1
serine--tRNA ligase

1

16

High-throughput

0.618

High

704336

PP1B
Serine/threonine-protein phosphatase beta isoform

2

2

High-throughput

0.584

High

53108

A1Z7K8
AaRS-interacting multifunctional protein 1

2

10

High-throughput

0.571

High

58073

A1ZBE9
Methionine--tRNA ligase, cytoplasmic

2

20

High-throughput

0.571

High

704331

2AAA
Serine/threonine-protein phosphatase PP2A 65 kDa regulatory subunit

2

1

High-throughput

0.571

High

704337

TCPG
T-complex protein 1 subunit gamma

2

1

High-throughput

0.571

High

704355

Q7K0E6
Aspartate--tRNA ligase, cytoplasmic

2

20

High-throughput

0.571

High

704364

Q8MSW0
Isoleucine--tRNA ligase, cytoplasmic

2

13

High-throughput

0.571

High

704377

Q9V455
Importin subunit alpha

2

1

High-throughput

0.571

High

704382

Q9VAW3
glutamine--fructose-6-phosphate transaminase

2

1

High-throughput

0.571

High

704396

NFS1
Cysteine desulfurase, mitochondrial

2

1

High-throughput

0.571

High

704409

AIMP2
Probable aminoacyl tRNA synthase complex-interacting multifunctional protein 2

2

3

High-throughput

0.571

High

704412

SYRC
Probable arginine--tRNA ligase, cytoplasmic

2

5

High-throughput

0.571

High

704368

Q8T0U6
Serine/threonine-protein phosphatase

2

2

High-throughput

0.570

High

437973

PYR1
Multifunctional protein r

2

0

High-throughput

0.547

High

704333

COPB
Coatomer subunit beta

2

1

High-throughput

0.521

High

704391

IPO9
Importin-9

2

3

High-throughput

0.521

High

704410

Q9VW54
26S proteasome non-ATPase regulatory subunit 2

2

4

High-throughput

0.521

High

704411

IDH3A
Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

2

3

High-throughput

0.521

High

262735

TENM
Teneurin-m

1

1

High-throughput

0.484

High

304930

CRY1
Cryptochrome-1

1

2

High-throughput

0.479

High

704357

Q7K3H0
LD28067p

1

2

High-throughput

0.479

High

704360

Q7KN97
Pyruvate carboxylase

1

3

High-throughput

0.479

High

704362

Q7KTD0
ABC-type glutathione-S-conjugate transporter

1

1

High-throughput

0.479

High

704378

Q9V470
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial

1

2

High-throughput

0.479

High

704383

Q9VAY2
Heat shock protein 83

1

15

High-throughput

0.479

High

704389

ATD3A
ATPase family AAA domain-containing protein 3A homolog

1

15

High-throughput

0.479

High

704395

Q9VK69
T-complex protein 1 subunit delta

1

1

High-throughput

0.479

High

704405

ACADM
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial

1

2

High-throughput

0.479

High

704406

Q9VSD6
D-Importin 7/RanBP7

1

3

High-throughput

0.479

High

704425

Q9Y162
vesicle-fusing ATPase

1

10

High-throughput

0.479

High

704348

RS5A
Small ribosomal subunit protein uS7A

1

0

High-throughput

0.458

High

704358

Q7K3J0
T-complex protein 1 subunit theta

1

0

High-throughput

0.458

High

704413

Q9VXQ5
Chaperonin containing TCP1 subunit 6

1

0

High-throughput

0.458

High

704346

Q0IGU0
IP21556p

1

2

High-throughput

0.451

High

55761

A1Z9K0
Uncharacterized protein, isoform B

1

4

High-throughput

0.445

High

704334

ACTZ
Actin-related protein 1

1

4

High-throughput

0.445

High

704335

KL61
Kinesin-like protein Klp61F

1

3

High-throughput

0.445

High

704339

POLO
Serine/threonine-protein kinase polo

1

1

High-throughput

0.445

High

704342

ARL2
ADP-ribosylation factor-like protein 2

1

3

High-throughput

0.445

High

704345

Q0E931
GTP-binding protein 1

1

8

High-throughput

0.445

High

704349

ISWI
Chromatin-remodeling complex ATPase chain Iswi

1

3

High-throughput

0.445

High

704350

MCM4
DNA replication licensing factor MCM4

1

4

High-throughput

0.445

High

704363

Q8IRE7
PAN2-PAN3 deadenylation complex subunit PAN3

1

1

High-throughput

0.445

High

704366

Q8SY39
ATP-dependent RNA helicase DDX54

1

6

High-throughput

0.445

High

704367

Q8SY53
GH11935p

1

1

High-throughput

0.445

High

704369

Q8T4G5
AFG3 like matrix AAA peptidase subunit 2, isoform A

1

3

High-throughput

0.445

High

704370

Q95U38
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

1

2

High-throughput

0.445

High

704372

Q9V3V6
26S proteasome regulatory complex subunit p50

1

15

High-throughput

0.445

High

704373

Q9V405
26S proteasome regulatory subunit 6B

1

3

High-throughput

0.445

High

704374

API5
Apoptosis inhibitor 5 homolog

1

1

High-throughput

0.445

High

704375

Q9V434
Asparagine--tRNA ligase, cytoplasmic

1

20

High-throughput

0.445

High

704380

Q9VAH7
N-terminal kinase-like protein

1

3

High-throughput

0.445

High

704384

DDX18
Probable ATP-dependent RNA helicase pitchoune

1

4

High-throughput

0.445

High

704392

Q9VI53
LD44267p

1

1

High-throughput

0.445

High

704393

DDX47
ATP-dependent RNA helicase DDX47

1

6

High-throughput

0.445

High

704394

RAGP1
Ran GTPase-activating protein

1

1

High-throughput

0.445

High

704414

Q9VXR5
ATP-binding cassette sub-family F member 2

1

6

High-throughput

0.445

High

704415

RENT1
Regulator of nonsense transcripts 1 homolog

1

4

High-throughput

0.445

High

704417

Q9VZ88
AT07585p

1

5

High-throughput

0.445

High

704419

Q9W0E4
Aminopeptidase

1

3

High-throughput

0.445

High

704421

Q9W414
Regulatory particle triple-A ATPase 4

1

3

High-throughput

0.445

High

704422

Q9XZ53
dolichyl-diphosphooligosaccharide--protein glycotransferase

1

1

High-throughput

0.445

High

704340

GSC
Homeobox protein goosecoid

1

2

High-throughput

0.439

High

52638

A1Z729
NADP-retinol dehydrogenase

1

1

High-throughput

0.437

High

704330

CLH
Clathrin heavy chain

1

1

High-throughput

0.437

High

704344

Q0E8E8
Phosphate carrier protein, mitochondrial

1

1

High-throughput

0.437

High

704347

SIMA
Protein similar

1

1

High-throughput

0.437

High

704381

Q9VAL7
Calnexin 99A, isoform A

1

1

High-throughput

0.437

High

704388

Q9VEV3
Tetratricopeptide repeat protein 1

1

9

High-throughput

0.437

High

704338

PFKA
ATP-dependent 6-phosphofructokinase

1

0

High-throughput

0.426

High

704343

ROP
Protein ROP

1

0

High-throughput

0.426

High

704398

Q9VMH3
LD04103p

1

0

High-throughput

0.426

High

704423

4EBP
Eukaryotic translation initiation factor 4E-binding protein

1

0

High-throughput

0.426

High

55409

A1Z9E3
Elongation factor Tu

1

4

High-throughput

0.407

High

69062

A8JRH3
FI20012p1

1

2

High-throughput

0.407

High

263361

PENG
Protein penguin

1

1

High-throughput

0.407

High

360515

COX2
Cytochrome c oxidase subunit 2

1

1

High-throughput

0.407

High

473591

RAS1
Ras-like protein 1

1

2

High-throughput

0.407

High

704332

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

2

High-throughput

0.407

High

704351

SARM1
NAD(+) hydrolase sarm1

1

1

High-throughput

0.407

High

704354

Q7JXU4
Nucleolar GTP-binding protein 2

1

1

High-throughput

0.407

High

704361

DYM
Dymeclin

1

1

High-throughput

0.407

High

704371

Q95WY3
Nucleolar protein 56

1

2

High-throughput

0.407

High

704379

Q9V9Q4
LD43819p

1

3

High-throughput

0.407

High

704385

Q9VDK7
Signal recognition particle subunit SRP72

1

2

High-throughput

0.407

High

704386

Q9VEH0
Aluminum tubes, isoform A

1

3

High-throughput

0.407

High

704387

Q9VEP0
Regulatory protein zeste

1

1

High-throughput

0.407

High

704390

Q9VGN4
Sarcomere length short, isoform B

1

2

High-throughput

0.407

High

704397

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

High-throughput

0.407

High

704402

Q9VQI5
Interferon-related developmental regulator 1

1

1

High-throughput

0.407

High

704407

SRP68
Signal recognition particle subunit SRP68

1

1

High-throughput

0.407

High

704408

FRL
Formin-like protein

1

1

High-throughput

0.407

High

704418

Q9VZU8
Alpha-1,3/1,6-mannosyltransferase ALG2

1

1

High-throughput

0.407

High

704420

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

1

High-throughput

0.407

High

99124

F2FB55
Receptor expression-enhancing protein

2

0

High-throughput

0.310

High

704353

Q7JRD4
Peroxisomal membrane protein PEX13

2

0

High-throughput

0.310

High

704416

Q9VZ71
RE01453p

2

0

High-throughput

0.310

High

53668

A1Z843
Nodal modulator 3

1

0

High-throughput

0.249

Low

94121

D5AEK7
1-Acylglycerol-3-phosphate O-acyltransferase 3, isoform E

1

0

High-throughput

0.249

Low

704341

CCD1P
Probable cytochrome P450 12d1 proximal, mitochondrial

1

0

High-throughput

0.249

Low

704352

Q76NQ0
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.249

Low

704356

Q7K110
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

704365

Q8STG9
DSec61alpha

1

0

High-throughput

0.249

Low

704376

KRH2
Krueppel homolog 2

1

0

High-throughput

0.249

Low

704404

Q9VS57
RE14391p

1

0

High-throughput

0.249

Low

704401

Q9VNF6
Metastasis-associated protein MTA3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025