Protein: HOSC
Homocitrate synthase, cytosolic isozyme (HCS) (EC 2.3.3.14)

Gene: HOSC, LYS20
Organism: Saccharomyces cerevisiae S288C
Interactions: 114
UniProt ID: P48570

Gene Ontology (top 5):
GO:0004410 - homocitrate synthase activity
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0006281 - DNA repair
GO:0019878 - lysine biosynthetic process via aminoadipic acid

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

874350

HOSM
Homocitrate synthase, mitochondrial

4

14

High-throughput

0.896

High

874325

HOSC
Homocitrate synthase, cytosolic isozyme

2

14

High-throughput

0.791

High

524493

HSP71
Heat shock protein SSA1

4

9

High-throughput

0.666

High

393005

HSP82
ATP-dependent molecular chaperone HSP82

2

8

High-throughput

0.584

High

739406

ZUO1
Zuotin

2

5

Small-scale

0.584

High

850088

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

5

High-throughput

0.584

High

545490

SSB1
Ribosome-associated molecular chaperone SSB1

2

10

High-throughput

0.571

High

579711

HSC82
ATP-dependent molecular chaperone HSC82

2

8

High-throughput

0.571

High

804287

SSZ1
Ribosome-associated complex subunit SSZ1

2

1

High-throughput

0.571

High

819206

SSB2
Ribosome-associated molecular chaperone SSB2

2

10

High-throughput

0.552

High

454460

PHO4
Phosphate system positive regulatory protein PHO4

1

1

High-throughput

0.536

High

382204

H4
Histone H4

1

1

Small-scale

0.501

High

670294

NAP1
Nucleosome assembly protein

1

0

High-throughput

0.493

High

782140

T2EB
Transcription initiation factor IIE subunit beta

1

0

High-throughput

0.493

High

796400

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

0

High-throughput

0.493

High

809360

STM1
Suppressor protein STM1

1

0

High-throughput

0.493

High

825361

DPH1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

1

0

High-throughput

0.493

High

874339

HMO1
High mobility group protein 1

1

0

High-throughput

0.493

High

874351

YRA1
RNA annealing protein YRA1

1

0

High-throughput

0.493

High

874355

ISA2
Iron-sulfur assembly protein 2

1

0

High-throughput

0.493

High

416136

SYTC
Threonine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

416260

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

3

High-throughput

0.479

High

441185

KAPA
cAMP-dependent protein kinase type 1

1

3

Small-scale

0.479

High

448760

SNF1
Carbon catabolite-derepressing protein kinase

1

1

Small-scale

0.479

High

594455

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

High-throughput

0.479

High

668318

IF2M
Translation initiation factor IF-2, mitochondrial

1

2

High-throughput

0.479

High

670903

SIS1
Protein SIS1

1

6

High-throughput

0.479

High

707585

TF2B
Transcription initiation factor IIB

1

6

High-throughput

0.479

High

735059

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

2

High-throughput

0.479

High

736390

MET4
Transcriptional activator of sulfur metabolism MET4

1

1

High-throughput

0.479

High

747940

SMY2
Protein SMY2

1

2

High-throughput

0.479

High

748758

YPT7
Ypt/Rab-type GTPase YPT7

1

1

Small-scale

0.479

High

750724

PRS6A
26S proteasome regulatory subunit 6A

1

5

High-throughput

0.479

High

783487

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

792135

GBLP
Small ribosomal subunit protein RACK1

1

3

Small-scale

0.479

High

793335

SYG
Glycine--tRNA ligase 1, mitochondrial

1

3

High-throughput

0.479

High

874332

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

2

High-throughput

0.479

High

874337

GIS1
Transcriptional activator/repressor GIS1

1

1

High-throughput

0.479

High

874338

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.479

High

874349

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

1

High-throughput

0.479

High

874352

RIO1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.479

High

435213

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

454173

SYH
Histidine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

647161

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.458

High

657107

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.458

High

661542

PSA2
Proteasome subunit alpha type-2

1

0

High-throughput

0.458

High

671929

RBSK
Ribokinase

1

0

High-throughput

0.458

High

803149

ECM29
Proteasome component ECM29

1

0

High-throughput

0.458

High

808791

LYS1
Saccharopine dehydrogenase [NAD(+), L-lysine-forming]

1

0

High-throughput

0.458

High

867848

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

0

High-throughput

0.458

High

874328

INO80
Chromatin-remodeling ATPase INO80

1

0

Small-scale

0.458

High

874329

SPC98
Spindle pole body component SPC98

1

0

High-throughput

0.458

High

874335

GCN5
Histone acetyltransferase GCN5

1

0

Small-scale

0.458

High

874340

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

874341

RPN9
26S proteasome regulatory subunit RPN9

1

0

High-throughput

0.458

High

874345

NHEJ1
Non-homologous end-joining protein 1

1

0

Small-scale

0.458

High

874346

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

874357

RKM4
Ribosomal lysine N-methyltransferase 4

1

0

High-throughput

0.458

High

510637

HSP77
Import motor subunit, mitochondrial

1

5

High-throughput

0.445

High

527116

HSP72
Heat shock protein SSA2

1

9

High-throughput

0.445

High

590670

HSP26
Heat shock protein 26

1

2

High-throughput

0.445

High

597199

BIP
Endoplasmic reticulum chaperone BiP

1

2

High-throughput

0.445

High

676147

MAS5
Mitochondrial protein import protein MAS5

1

2

High-throughput

0.445

High

727165

HS104
Heat shock protein 104

1

6

High-throughput

0.445

High

741934

HSP7F
Heat shock protein homolog SSE1

1

14

High-throughput

0.445

High

742894

HSP79
Heat shock protein homolog SSE2

1

14

High-throughput

0.445

High

752483

HSP78
Heat shock protein 78, mitochondrial

1

6

High-throughput

0.445

High

763460

MDJ1
DnaJ homolog 1, mitochondrial

1

4

High-throughput

0.445

High

811348

CAJ1
Protein CAJ1

1

3

High-throughput

0.445

High

874334

APJ1
J domain-containing protein APJ1

1

2

High-throughput

0.445

High

368910

SYMC
Methionine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.437

High

511341

RL43A
Large ribosomal subunit protein eL43A

1

1

High-throughput

0.437

High

511446

RL43B
Large ribosomal subunit protein eL43B

1

1

High-throughput

0.437

High

558800

CAF20
Cap-associated protein CAF20

1

3

High-throughput

0.437

High

581881

SYKC
Lysine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.437

High

687599

SYLC
Leucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.437

High

748464

SC61A
Protein transport protein SEC61

1

2

High-throughput

0.437

High

762386

PEX5
Peroxisomal targeting signal receptor

1

3

High-throughput

0.437

High

802570

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.437

High

802655

YHI0
Putative proline--tRNA ligase YHR020W

1

2

High-throughput

0.437

High

871432

HLJ1
Protein HLJ1

1

3

High-throughput

0.437

High

874330

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

1

1

High-throughput

0.437

High

874354

DBP10
ATP-dependent RNA helicase DBP10

1

2

High-throughput

0.437

High

844410

TCPH
T-complex protein 1 subunit eta

1

2

High-throughput

0.407

High

874347

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

2

High-throughput

0.407

High

874353

HSP42
Heat shock protein 42

1

2

High-throughput

0.407

High

435599

RS9B
Small ribosomal subunit protein uS4B

1

0

High-throughput

0.269

Low

672114

PUF4
Pumilio homology domain family member 4

1

0

High-throughput

0.269

Low

794928

YBI6
Uncharacterized protein YBL086C

1

0

High-throughput

0.269

Low

801697

GLO3
ADP-ribosylation factor GTPase-activating protein GLO3

1

0

High-throughput

0.269

Low

835828

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.269

Low

874327

RL37B
Large ribosomal subunit protein eL37B

1

0

High-throughput

0.269

Low

874333

NAT10
RNA cytidine acetyltransferase

1

0

High-throughput

0.269

Low

874343

RRP5
rRNA biogenesis protein RRP5

1

0

High-throughput

0.269

Low

410221

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

434607

RL22A
Large ribosomal subunit protein eL22A

1

0

High-throughput

0.249

Low

442003

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

504304

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

632908

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

1

0

High-throughput

0.249

Low

674717

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.249

Low

689548

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

778421

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

780780

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.249

Low

812463

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

874326

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

874331

PDR16
Phosphatidylinositol transfer protein PDR16

1

0

High-throughput

0.249

Low

874336

YMC0
Uncharacterized protein YML020W

1

0

High-throughput

0.249

Low

874344

CYK2
Cytokinesis protein 2

1

0

High-throughput

0.249

Low

874348

ENB1
Siderophore iron transporter ENB1

1

0

High-throughput

0.249

Low

874356

EMC6
ER membrane protein complex subunit 6

1

0

High-throughput

0.249

Low

812246

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.232

Low

816723

PFD2
Prefoldin subunit 2

1

0

High-throughput

0.232

Low

874342

HSP31
Glutathione-independent glyoxalase HSP31

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025