HitPredict

Interactor 1: CRKL (P46109)
Crk-like protein
Gene: CRKL

Interactor 2: GAB1 (Q13480)
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Gene: GAB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.886

Property	Details
Experiments	24728074, 10753869, 30480076, 31585087
Identification Methods	pull down, affinity chromatography technology, anti bait coimmunoprecipitation, fluorescence polarization spectroscopy
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction GO:0035591 - signaling adaptor activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 303 Hs			1 694
+	Hs
		802588 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Mm
		1246955 Q8R5B8_MOUSE (1-98): 1.74e-50: 163: 97.96		GAB1_MOUSE (1-694): 0: 544: 89.93
+	Hs
		855792 VAV2_HUMAN (14-180): 4.46e-40: 150: 19.80		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		802920 CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00		GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01
+	Hs
		275195 GRAP2_HUMAN (4-291): 5.79e-36: 133: 14.97		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Mm
		292690 GRAP2_MOUSE (4-291): 5.63e-37: 136: 15.25		GAB1_MOUSE (1-694): 0: 544: 89.93
+	Hs
		581001 PLCG1_HUMAN (5-224): 1.42e-28: 117: 17.80		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Mm
		1143296 PLCG1_MOUSE (5-224): 3.19e-29: 119: 16.95		GAB1_MOUSE (1-694): 0: 544: 89.93
+	Hs
		562645 PLCG2_HUMAN (5-188): 2.6e-27: 113: 19.10		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		802781 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01
+	Hs
		557681 NCK1_HUMAN (85-196): 4.12e-16: 79.8: 22.81		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		275242 GRAP2_HUMAN (4-291): 5.79e-36: 133: 14.97		GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01
+	Hs
		581081 PLCG1_HUMAN (5-224): 1.42e-28: 117: 17.80		GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01
+	Hs
		562669 PLCG2_HUMAN (5-188): 2.6e-27: 113: 19.10		GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01
+	Mm
		292691 GRAP2_MOUSE (4-291): 5.63e-37: 136: 15.25		GAB2_MOUSE (3-691): 8.7e-141: 429: 38.33
+	Hs
		1040322 GRAP_HUMAN (126-294): 1.63e-24: 100: 19.07		GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01
+	Hs
		557834 NCK1_HUMAN (85-196): 4.12e-16: 79.8: 22.81		GAB2_HUMAN (3-691): 2.24e-153: 461: 39.01
+	Hs
		802856 CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00		PKHA7_HUMAN (5-485): 5.86e-74: 260: 12.07
+	Dm
		993221 GRAP_DROME (126-293): 1.68e-23: 97.6: 17.79		DOS_DROME (7-655): 6.26e-82: 279: 18.50
+	Hs
		802907 CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49