Protein: CYS3
Cystathionine gamma-lyase (gamma-CTLase) (EC 4.4.1.1) (Gamma-cystathionase) (Sulfur transfer protein 1)

Gene: CYS3
Organism: Saccharomyces cerevisiae S288C
Interactions: 62
UniProt ID: P31373

Gene Ontology (top 5):
GO:0004123 - cystathionine gamma-lyase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0019343 - cysteine biosynthetic process via cystathionine
GO:0019344 - cysteine biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

725873

CYS3
Cystathionine gamma-lyase

2

7

Small-scale

0.767

High

392377

HSP82
ATP-dependent molecular chaperone HSP82

3

4

High-throughput

0.640

High

523299

HSP71
Heat shock protein SSA1

3

9

High-throughput

0.633

High

725881

YHR2
Uncharacterized trans-sulfuration enzyme YHR112C

1

7

High-throughput

0.618

High

400059

PUR1
Amidophosphoribosyltransferase

2

0

High-throughput

0.576

High

544096

SSB1
Ribosome-associated molecular chaperone SSB1

2

8

High-throughput

0.571

High

526128

HSP72
Heat shock protein SSA2

2

9

High-throughput

0.552

High

725892

BRE5
UBP3-associated protein BRE5

1

1

High-throughput

0.536

High

670434

SIS1
Protein SIS1

1

3

High-throughput

0.515

High

602115

SPO12
Sporulation-specific protein 12

1

0

High-throughput

0.513

High

624979

PRP6
Pre-mRNA-splicing factor 6

1

0

High-throughput

0.513

High

725905

ATG5
Autophagy protein 5

1

0

High-throughput

0.513

High

649476

UBA1
Ubiquitin-activating enzyme E1 1

1

0

High-throughput

0.493

High

725885

ULP2
Ubiquitin-like-specific protease 2

1

1

High-throughput

0.481

High

725894

ULP1
Ubiquitin-like-specific protease 1

1

1

High-throughput

0.481

High

517945

SSBP1
Single-stranded nucleic acid-binding protein

1

0

High-throughput

0.480

High

149640

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.479

High

401921

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

1

High-throughput

0.479

High

434906

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

514511

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

579000

HSC82
ATP-dependent molecular chaperone HSC82

1

4

High-throughput

0.479

High

674472

RS2
Small ribosomal subunit protein uS5

1

2

High-throughput

0.479

High

706430

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

725874

HS104
Heat shock protein 104

1

1

High-throughput

0.479

High

725879

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.479

High

725893

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

725895

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.479

High

725897

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

725904

RRP6
Exosome complex exonuclease RRP6

1

1

High-throughput

0.479

High

435834

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

464569

PBS2
MAP kinase kinase PBS2

1

0

High-throughput

0.458

High

725875

HOG1
Mitogen-activated protein kinase HOG1

1

0

High-throughput

0.458

High

725880

TRM7
tRNA

1

0

High-throughput

0.458

High

725882

DHH1
ATP-dependent RNA helicase DHH1

1

0

High-throughput

0.458

High

725887

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

725889

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

725890

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

725891

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

725896

RUVB1
RuvB-like protein 1

1

0

High-throughput

0.458

High

725899

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

725903

MLH3
DNA mismatch repair protein MLH3

1

0

High-throughput

0.458

High

510277

HSP77
Import motor subunit, mitochondrial

1

1

High-throughput

0.445

High

725876

HSP7F
Heat shock protein homolog SSE1

1

13

High-throughput

0.445

High

725877

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.445

High

725884

SSB2
Ribosome-associated molecular chaperone SSB2

1

8

High-throughput

0.445

High

383575

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.437

High

409988

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.437

High

433507

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.437

High

441764

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.437

High

502904

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

725883

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

725902

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

725906

DBP10
ATP-dependent RNA helicase DBP10

1

1

High-throughput

0.437

High

725886

DJP1
DnaJ-like protein 1

1

2

High-throughput

0.407

High

725900

HRD1
ERAD-associated E3 ubiquitin-protein ligase HRD1

1

0

High-throughput

0.269

Low

725888

BNI1
Protein BNI1

1

0

High-throughput

0.261

Low

454930

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

725878

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

725901

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

577058

SEC63
Protein translocation protein SEC63

1

0

High-throughput

0.232

Low

725898

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025