HitPredict

Interactor 1: CRKL (P46109)
Crk-like protein
Gene: CRKL

Interactor 2: PRAG1 (Q86YV5)
Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223)
Gene: PRAG1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	26496610, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0016477 - cell migration
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 303 Hs			1 1406
+	Hs
		802648 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		PRAG1_HUMAN (1-1406): 0: 2304: 100.00
+	Hs
		782802 CSK_HUMAN (129-180): 8.43e-11: 64.1: 43.40		PRAG1_HUMAN (1-1406): 0: 2304: 100.00
+	Hs
		924680 GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32		PRAG1_HUMAN (1-1406): 0: 2304: 100.00
+	Mm
		1123037 CRK_MOUSE (3-302): 5.71e-54: 180: 55.21		PRAG1_MOUSE (14-1395): 0: 2121: 75.14
+	Hs
		802905 CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00		PEAK1_HUMAN (14-104): 7.59e-10: 66: 40.43
+	Hs
		802730 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		PEAK1_HUMAN (14-104): 7.59e-10: 66: 40.43
+	Hs
		782826 CSK_HUMAN (129-180): 8.43e-11: 64.1: 43.40		PEAK1_HUMAN (14-104): 7.59e-10: 66: 40.43
+	Hs
		924867 GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32		PEAK1_HUMAN (14-104): 7.59e-10: 66: 40.43
+	Hs
		209171 NCK2_HUMAN (72-204): 1.51e-09: 60.1: 21.48		PEAK1_HUMAN (14-104): 7.59e-10: 66: 40.43
+	Mm
		1141136 GRB2_MOUSE (240-295): 1.96e-10: 61.4: 26.32		PEAK1_MOUSE (14-104): 2.33e-09: 64.4: 41.49