HitPredict

Interactor 1: MP2K3 (P46734)
Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3) (Stress-activated protein kinase kinase 2) (SAPK kinase 2) (SAPKK-2) (SAPKK2)
Gene: MAP2K3

Interactor 2: JIP3 (Q9UPT6)
C-Jun-amino-terminal kinase-interacting protein 3 (JIP-3) (JNK-interacting protein 3) (JNK MAP kinase scaffold protein 3) (Mitogen-activated protein kinase 8-interacting protein 3)
Gene: MAPK8IP3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	20173330
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 347 Hs			1 1336
+	Hs
		801006 MP2K4_HUMAN (1-345): 1.56e-114: 339: 47.80		JIP3_HUMAN (1-1336): 0: 998: 100.00
+	Hs
		153188 MP2K7_HUMAN (49-345): 3.41e-108: 324: 43.81		JIP3_HUMAN (1-1336): 0: 998: 100.00
+	Mm
		814033 MP2K4_MOUSE (6-345): 3.21e-113: 336: 47.67		JIP3_MOUSE (1-1336): 0: 954: 93.72
+	Mm
		1208258 MP2K7_MOUSE (2-345): 8.59e-109: 329: 38.54		JIP3_MOUSE (1-1336): 0: 954: 93.72
+	Hs
		972271 MP2K1_HUMAN (49-344): 5.25e-65: 212: 36.69		JIP3_HUMAN (1-1336): 0: 998: 100.00
+	Mm
		682480 MP2K1_MOUSE (49-344): 4.47e-65: 212: 36.69		JIP3_MOUSE (1-1336): 0: 954: 93.72
+	Hs
		229642 MP2K3_HUMAN (1-347): 1.73e-124: 362: 100.00		JIP4_HUMAN (6-1336): 0: 671: 54.25
+	Hs
		229641 MP2K4_HUMAN (1-345): 1.56e-114: 339: 47.80		JIP4_HUMAN (6-1336): 0: 671: 54.25
+	Hs
		229635 MP2K2_HUMAN (49-343): 4.4e-63: 207: 35.78		JIP4_HUMAN (6-1336): 0: 671: 54.25
+	Hs
		681696 AKT1_HUMAN (36-345): 1.71e-127: 375: 20.76		MYH9_HUMAN (228-774): 4.87e-21: 102: 8.04
+	Hs
		724784 KPCE_HUMAN (3-344): 9.69e-120: 363: 19.89		MYH9_HUMAN (228-774): 4.87e-21: 102: 8.04
+	Hs
		551616 AKT1_HUMAN (36-345): 1.71e-127: 375: 20.76		DESP_HUMAN (27-706): 3.94e-16: 86.8: 11.43
+	Ce
		106072 SEK1_CAEEL (14-344): 1.53e-111: 329: 49.85		JIP_CAEEL (21-482): 2.09e-29: 129: 26.85
+	Hs
		625530 CDK2_HUMAN (61-336): 3.55e-114: 335: 23.43		MY18A_HUMAN (189-793): 1.74e-25: 117: 9.00
+	Hs
		551672 KPCE_HUMAN (3-344): 9.69e-120: 363: 19.89		DESP_HUMAN (27-706): 3.94e-16: 86.8: 11.43
+	Hs
		625177 CDK2_HUMAN (61-336): 3.55e-114: 335: 23.43		MYH10_HUMAN (243-769): 2.9e-24: 113: 8.89
+	Hs
		625176 CDK2_HUMAN (61-336): 3.55e-114: 335: 23.43		MYH9_HUMAN (228-774): 4.87e-21: 102: 8.04
+	Hs
		551610 CDK2_HUMAN (61-336): 3.55e-114: 335: 23.43		DESP_HUMAN (27-706): 3.94e-16: 86.8: 11.43
+	Hs
		1023100 STK4_HUMAN (42-345): 1.62e-103: 314: 33.12		AKAP9_HUMAN (45-563): 1.97e-11: 71.2: 13.56
+	Hs
		551881 STK24_HUMAN (53-339): 2.62e-96: 294: 27.34		DESP_HUMAN (27-706): 3.94e-16: 86.8: 11.43