Protein: EPN3
Epsin-3 (EPS-15-interacting protein 3)

Gene: EPN3
Organism: Homo sapiens
Interactions: 56
UniProt ID: Q9H201

Gene Ontology (top 5):
GO:0005543 - phospholipid binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005768 - endosome
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

329485

EPN2
Epsin-2

3

14

High-throughput

0.861

High

507364

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

3

20

High-throughput

0.861

High

1431394

EPN1
Epsin-1

3

12

High-throughput

0.861

High

508607

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

3

20

Small-scale

0.825

High

209670

SERA
D-3-phosphoglycerate dehydrogenase

3

3

High-throughput

0.667

High

332445

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

3

3

High-throughput

0.667

High

1429753

BTBD1
BTB/POZ domain-containing protein 1

3

1

High-throughput

0.667

High

1431381

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

3

3

High-throughput

0.667

High

1431382

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

3

7

High-throughput

0.667

High

1431385

SMUF1
E3 ubiquitin-protein ligase SMURF1

3

7

High-throughput

0.667

High

1431387

TRIM1
Probable E3 ubiquitin-protein ligase MID2

3

16

High-throughput

0.667

High

1431388

FEM1B
Protein fem-1 homolog B

3

5

High-throughput

0.667

High

1431391

ARI1
E3 ubiquitin-protein ligase ARIH1

3

8

High-throughput

0.667

High

1431392

KCTD3
BTB/POZ domain-containing protein KCTD3

3

8

High-throughput

0.667

High

840125

CASP2
Caspase-2

3

0

High-throughput

0.638

High

186581

TRI18
E3 ubiquitin-protein ligase Midline-1

4

16

High-throughput

0.634

High

1295553

MIB1
E3 ubiquitin-protein ligase MIB1

2

7

High-throughput

0.628

High

987208

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

15

High-throughput

0.621

High

987471

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

9

High-throughput

0.621

High

1348688

SHKB1
SH3KBP1-binding protein 1

3

12

High-throughput

0.609

High

1394865

VPS39
Vam6/Vps39-like protein

3

2

High-throughput

0.609

High

971990

1433E
14-3-3 protein epsilon

2

1

High-throughput

0.571

High

1400459

BTBD9
BTB/POZ domain-containing protein 9

2

2

High-throughput

0.558

High

517297

ZTRF1
Zinc finger TRAF-type-containing protein 1

2

1

High-throughput

0.552

High

48070

RBM47
RNA-binding protein 47

1

2

High-throughput

0.536

High

1117921

BACD2
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2

1

9

High-throughput

0.536

High

573667

ENPL
Endoplasmin

1

4

High-throughput

0.515

High

1164398

TPD53
Tumor protein D53

1

0

High-throughput

0.513

High

1395817

ZC3HA
Zinc finger CCCH domain-containing protein 10

1

0

High-throughput

0.513

High

1431390

RTCB
RNA-splicing ligase RtcB homolog

1

0

High-throughput

0.513

High

1110934

LAPM5
Lysosomal-associated transmembrane protein 5

1

2

High-throughput

0.508

High

1431389

RNF11
RING finger protein 11

1

3

High-throughput

0.508

High

1431384

PAAT
ATPase PAAT

1

4

High-throughput

0.489

High

302638

RNF8
E3 ubiquitin-protein ligase RNF8

1

5

High-throughput

0.481

High

1089268

TRI26
Tripartite motif-containing protein 26

1

3

High-throughput

0.481

High

1139132

DAZP2
DAZ-associated protein 2

1

3

High-throughput

0.481

High

1392901

NTAQ1
Protein N-terminal glutamine amidohydrolase

1

1

High-throughput

0.481

High

1406899

LITAF
Lipopolysaccharide-induced tumor necrosis factor-alpha factor

1

4

High-throughput

0.481

High

374919

RASH
GTPase HRas

1

9

High-throughput

0.479

High

556334

CADH1
Cadherin-1

1

4

High-throughput

0.479

High

761510

HS71L
Heat shock 70 kDa protein 1-like

1

5

High-throughput

0.479

High

839821

EPS15
Epidermal growth factor receptor substrate 15

1

20

Small-scale

0.479

High

1093422

TRI32
E3 ubiquitin-protein ligase TRIM32

1

10

High-throughput

0.479

High

1114270

CUL3
Cullin-3

1

4

High-throughput

0.479

High

1145921

RBP1
RalA-binding protein 1

1

5

Small-scale

0.479

High

1289304

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

6

High-throughput

0.479

High

1367246

ESR2
Estrogen receptor beta

1

13

High-throughput

0.479

High

1431383

EHD1
EH domain-containing protein 1

1

20

Small-scale

0.479

High

1431386

EHD2
EH domain-containing protein 2

1

20

Small-scale

0.479

High

718625

CDC27
Cell division cycle protein 27 homolog

1

0

High-throughput

0.458

High

1199691

KLH22
Kelch-like protein 22

1

1

High-throughput

0.445

High

1234948

PKHA7
Pleckstrin homology domain-containing family A member 7

1

17

High-throughput

0.445

High

1364824

F168A
Protein FAM168A

1

2

High-throughput

0.439

High

1311105

UBR1
E3 ubiquitin-protein ligase UBR1

2

0

High-throughput

0.328

High

569273

YJU2B
Probable splicing factor YJU2B

1

0

High-throughput

0.279

Low

1431393

INSI2
Insulin-induced gene 2 protein

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025