HitPredict

Interactor 1: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Interactor 2: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	16055720
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1319 Hs			1 551
+	Sc
		376913 TOM1_YEAST (899-1317): 8.1e-155: 520: 40.42		PABP_YEAST (82-174): 3.01e-12: 71.1: 27.96
+	Hs
		1084614 WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		125492 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		1084573 ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		1084629 SMUF1_HUMAN (539-719): 7.11e-18: 91.8: 16.82		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		1235798 WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		125259 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		SMCA2_HUMAN (179-551): 2.13e-47: 180: 14.93
+	Hs
		125581 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		125260 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98
+	Hs
		1235773 ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		846873 SMUF2_HUMAN (454-719): 3.19e-26: 118: 17.86		SMCA2_HUMAN (179-551): 2.13e-47: 180: 14.93
+	Hs
		125430 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		PABP4_HUMAN (81-517): 7.23e-31: 129: 13.51
+	Hs
		125122 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		1311993 WWP1_HUMAN (389-800): 7.48e-49: 191: 17.86		DIDO1_HUMAN (164-416): 4.81e-09: 61.5: 21.59
+	Hs
		125274 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		SC24C_HUMAN (233-440): 1.79e-12: 72.2: 17.05
+	Hs
		125061 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		SC24D_HUMAN (131-353): 2.02e-11: 68.8: 21.49
+	Hs
		516643 ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		125687 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		DIDO1_HUMAN (164-416): 4.81e-09: 61.5: 21.59
+	Hs
		125698 WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91		WDR33_HUMAN (180-396): 5.21e-09: 61.5: 24.69
+	Mm
		1208066 WWP2_MOUSE (381-669): 4.39e-33: 141: 13.37		DIDO1_MOUSE (151-446): 1.18e-09: 63.3: 17.16