Protein: TNKS1
Poly [ADP-ribose] polymerase tankyrase-1 (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 5) (ARTD5) (Poly [ADP-ribose] polymerase 5A) (Protein poly-ADP-ribosyltransferase tankyrase-1) (EC 2.4.2.-) (TNKS-1) (TRF1-interacting ankyrin-related ADP-ribose polymerase) (Tankyrase I) (Tankyrase-1) (TANK1)

Gene: TNKS1, TNKS
Organism: Homo sapiens
Interactions: 105
UniProt ID: O95271

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0000209 - protein polyubiquitination
GO:0000242 - pericentriolar material
GO:0000781 - chromosome, telomeric region
GO:0003950 - NAD+ poly-ADP-ribosyltransferase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

332454

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

6

12

Small-scale

0.945

High

332381

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

5

14

Small-scale

0.917

High

332461

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

2

11

High-throughput

0.811

High

332399

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

2

1

Small-scale

0.808

High

140091

SDCB1
Syntenin-1

2

9

High-throughput

0.783

High

332425

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

2

3

High-throughput

0.783

High

332392

TERF1
Telomeric repeat-binding factor 1

17

2

Small-scale

0.765

High

332433

FNBP1
Formin-binding protein 1

1

4

Small-scale

0.756

High

332455

BABA1
BRISC and BRCA1-A complex member 1

7

1

Small-scale

0.750

High

332452

RN146
E3 ubiquitin-protein ligase RNF146

5

1

Small-scale

0.726

High

332446

GO45
Golgin-45

5

1

Small-scale

0.712

High

177156

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

1

13

High-throughput

0.698

High

251353

GMDS
GDP-mannose 4,6 dehydratase

4

2

Small-scale

0.696

High

239291

MYPT2
Protein phosphatase 1 regulatory subunit 12B

1

19

High-throughput

0.691

High

299723

MPDZ
Multiple PDZ domain protein

1

4

High-throughput

0.691

High

330533

KI20A
Kinesin-like protein KIF20A

1

6

High-throughput

0.691

High

332415

ANKS3
Ankyrin repeat and SAM domain-containing protein 3

1

17

High-throughput

0.691

High

332439

S35A5
UDP-sugar transporter protein SLC35A5

4

1

High-throughput

0.691

High

332458

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

3

7

Small-scale

0.684

High

181041

AXIN1
Axin-1

4

6

Small-scale

0.683

High

332417

3BP5L
SH3 domain-binding protein 5-like

3

3

Small-scale

0.667

High

332427

RN166
E3 ubiquitin-protein ligase RNF166

3

3

High-throughput

0.667

High

332445

EPN3
Epsin-3

3

3

High-throughput

0.667

High

238996

ZNRD2
Protein ZNRD2

3

1

High-throughput

0.662

High

332419

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

3

2

High-throughput

0.662

High

332451

DISC1
Disrupted in schizophrenia 1 protein

3

4

High-throughput

0.661

High

332395

IF4A1
Eukaryotic initiation factor 4A-I

1

2

Small-scale

0.647

High

332459

LCAP
Leucyl-cystinyl aminopeptidase

3

2

Small-scale

0.646

High

239409

3BP5
SH3 domain-binding protein 5

3

3

Small-scale

0.645

High

332443

TB182
182 kDa tankyrase-1-binding protein

2

19

Small-scale

0.643

High

257295

PAGE4
P antigen family member 4

2

3

High-throughput

0.639

High

332440

TINF2
TERF1-interacting nuclear factor 2

3

0

Small-scale

0.634

High

332400

LRP1
Prolow-density lipoprotein receptor-related protein 1

2

4

High-throughput

0.628

High

332422

CELF5
CUGBP Elav-like family member 5

2

4

High-throughput

0.628

High

332429

AP2M1
AP-2 complex subunit mu

2

3

High-throughput

0.628

High

332460

TNIK
TRAF2 and NCK-interacting protein kinase

1

10

High-throughput

0.621

High

332387

APC
Adenomatous polyposis coli protein

1

18

Small-scale

0.618

High

332388

CTNB1
Catenin beta-1

1

4

Small-scale

0.618

High

332389

BRCA1
Breast cancer type 1 susceptibility protein

1

3

Small-scale

0.618

High

332396

RAN
GTP-binding nuclear protein Ran

1

2

Small-scale

0.618

High

332407

STK11
Serine/threonine-protein kinase STK11

1

1

Small-scale

0.618

High

332436

BARD1
BRCA1-associated RING domain protein 1

1

16

Small-scale

0.618

High

332465

RPGF2
Rap guanine nucleotide exchange factor 2

1

3

High-throughput

0.618

High

332412

CE170
Centrosomal protein of 170 kDa

2

15

High-throughput

0.611

High

332462

SL9A8
Sodium/hydrogen exchanger 8

2

2

High-throughput

0.601

High

332393

TCL1A
T-cell leukemia/lymphoma protein 1A

2

0

High-throughput

0.580

High

332416

EPMIP
EPM2A-interacting protein 1

2

0

High-throughput

0.580

High

332456

ADPRS
ADP-ribosylhydrolase ARH3

2

0

High-throughput

0.580

High

332466

OARD1
ADP-ribose glycohydrolase OARD1

2

0

High-throughput

0.580

High

332442

FACD2
Fanconi anemia group D2 protein

1

2

Small-scale

0.578

High

62083

KLRG2
Killer cell lectin-like receptor subfamily G member 2

2

1

High-throughput

0.574

High

332414

F117B
Protein FAM117B

2

1

High-throughput

0.574

High

332424

ARH40
Rho guanine nucleotide exchange factor 40

2

12

High-throughput

0.571

High

332390

CDN1A
Cyclin-dependent kinase inhibitor 1

1

2

Small-scale

0.561

High

332394

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

7

Small-scale

0.561

High

332418

MAVS
Mitochondrial antiviral-signaling protein

1

11

Small-scale

0.561

High

332404

MDC1
Mediator of DNA damage checkpoint protein 1

1

14

Small-scale

0.552

High

332435

CGRE1
Cell growth regulator with EF hand domain protein 1

2

1

High-throughput

0.549

High

248650

PEPL
Periplakin

1

20

High-throughput

0.536

High

332382

FRIL
Ferritin light chain

1

1

High-throughput

0.536

High

332384

HXB2
Homeobox protein Hox-B2

1

16

High-throughput

0.536

High

332401

STRN3
Striatin-3

1

11

High-throughput

0.536

High

332437

SOST
Sclerostin

1

1

High-throughput

0.536

High

332386

EPHA1
Ephrin type-A receptor 1

1

8

High-throughput

0.528

High

332405

NUMA1
Nuclear mitotic apparatus protein 1

1

13

Small-scale

0.527

High

277493

H2AY
Core histone macro-H2A.1

1

3

Small-scale

0.515

High

332383

XRCC6
X-ray repair cross-complementing protein 6

1

1

High-throughput

0.515

High

332409

INAVA
Innate immunity activator protein

1

0

Small-scale

0.513

High

332438

PYM1
Partner of Y14 and mago

1

0

High-throughput

0.513

High

332444

REN3A
Regulator of nonsense transcripts 3A

1

0

High-throughput

0.513

High

332450

M1IP1
Mid1-interacting protein 1

1

0

High-throughput

0.513

High

269476

PLCH2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2

1

1

High-throughput

0.501

High

332391

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

3

High-throughput

0.501

High

332402

CAC1S
Voltage-dependent L-type calcium channel subunit alpha-1S

1

5

High-throughput

0.501

High

332441

INP5K
Inositol polyphosphate 5-phosphatase K

1

1

High-throughput

0.501

High

332432

CC85A
Coiled-coil domain-containing protein 85A

1

1

High-throughput

0.489

High

332448

PCDH9
Protocadherin-9

1

1

High-throughput

0.489

High

332385

NELFE
Negative elongation factor E

1

0

Small-scale

0.480

High

332403

NUCG
Endonuclease G, mitochondrial

1

0

High-throughput

0.480

High

332430

DTBP1
Dysbindin

1

0

High-throughput

0.480

High

172364

XPO1
Exportin-1

1

8

High-throughput

0.479

High

332398

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

332406

TERF2
Telomeric repeat-binding factor 2

1

2

High-throughput

0.479

High

332410

AMOT
Angiomotin

1

14

Small-scale

0.479

High

332413

TENS2
Tensin-2

1

2

High-throughput

0.479

High

332421

AMOL1
Angiomotin-like protein 1

1

18

Small-scale

0.479

High

332434

RANB9
Ran-binding protein 9

1

2

Small-scale

0.479

High

332449

CPAP
Centrosomal P4.1-associated protein

1

8

Small-scale

0.479

High

332463

AMOL2
Angiomotin-like protein 2

1

14

Small-scale

0.479

High

278790

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.458

High

332453

POTE1
Protection of telomeres protein 1

1

0

Small-scale

0.458

High

332467

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

0

Small-scale

0.458

High

332423

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

4

High-throughput

0.445

High

332464

AXIN2
Axin-2

1

6

Small-scale

0.445

High

332397

3BP2
SH3 domain-binding protein 2

1

5

Small-scale

0.437

High

332420

APLF
Aprataxin and PNK-like factor

1

0

High-throughput

0.426

High

332426

SEN15
tRNA-splicing endonuclease subunit Sen15

1

0

High-throughput

0.426

High

332411

FBLN7
Fibulin-7

1

8

High-throughput

0.407

High

332431

C170L
Cep170-like protein

1

2

High-throughput

0.407

High

275476

RTN2
Reticulon-2

3

0

High-throughput

0.347

High

332408

TMM44
Transmembrane protein 44

2

0

High-throughput

0.328

High

332447

GARE1
GRB2-associated and regulator of MAPK protein 1

1

0

High-throughput

0.279

Low

332428

RUND1
RUN domain-containing protein 1

1

0

High-throughput

0.261

Low

332457

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025