HitPredict

Interactor 1: MED21 (P47822)
Mediator of RNA polymerase II transcription subunit 21 (Mediator complex subunit 21) (RNAPII complex component SRB7) (Suppressor of RNA polymerase B 7)
Gene: SRB7

Interactor 2: MED10 (Q06213)
Mediator of RNA polymerase II transcription subunit 10 (Mediator complex subunit 10) (Negative regulator of URS2 protein 2)
Gene: NUT2

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.90	0.917

The method score is based on:

Property	Details
Experiments	11555651, 11470794, 16554755, 16758199, 27688401, 15477388, 15710619, 37968396
Identification Methods	affinity chromatography technology, two hybrid, biochemical, tandem affinity purification
Interaction Type	physical association, direct interaction, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	Med10~Med21
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003712 - transcription coregulator activity GO:0005634 - nucleus GO:0016592 - mediator complex GO:0032968 - positive regulation of transcription elongation by RNA polymerase II and 4 others more... GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0051123 - RNA polymerase II preinitiation complex assembly GO:0060261 - positive regulation of transcription initiation by RNA polymerase II GO:0070847 - core mediator complex
Homologous interactions	0

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024