Protein: PRP45
Pre-mRNA-processing protein 45

Gene: PRP45
Organism: Saccharomyces cerevisiae S288C
Interactions: 114
UniProt ID: P28004

Gene Ontology (top 5):
GO:0000350 - generation of catalytic spliceosome for second transesterification step
GO:0000398 - mRNA splicing, via spliceosome
GO:0000974 - Prp19 complex
GO:0005634 - nucleus
GO:0071006 - U2-type catalytic step 1 spliceosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

700167

PRP46
Pre-mRNA-splicing factor PRP46

9

5

Small-scale

0.977

High

700162

CWC2
Pre-mRNA-splicing factor CWC2

6

5

Small-scale

0.949

High

700141

CEF1
Pre-mRNA-splicing factor CEF1

6

2

Small-scale

0.947

High

700112

PRP17
Pre-mRNA-processing factor 17

3

7

High-throughput

0.855

High

700084

PRP8
Pre-mRNA-splicing factor 8

2

3

High-throughput

0.789

High

700143

SYF1
Pre-mRNA-splicing factor SYF1

7

7

Small-scale

0.746

High

700076

PRP19
Pre-mRNA-processing factor 19

5

6

Small-scale

0.714

High

700166

CLF1
Pre-mRNA-splicing factor CLF1

5

8

Small-scale

0.713

High

700161

RU2A
U2 small nuclear ribonucleoprotein A'

5

2

Small-scale

0.712

High

700072

YJU2
Splicing factor YJU2

4

2

Small-scale

0.683

High

700124

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

3

7

High-throughput

0.671

High

700077

PRP21
Pre-mRNA-splicing factor PRP21

3

1

High-throughput

0.662

High

700091

SN114
Pre-mRNA-splicing factor SNU114

3

3

High-throughput

0.662

High

700120

SF3B1
U2 snRNP component HSH155

3

6

High-throughput

0.662

High

700145

RSE1
Pre-mRNA-splicing factor RSE1

3

3

High-throughput

0.662

High

700134

ADA2
SAGA complex subunit ADA2

1

3

High-throughput

0.656

High

664577

PRP22
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22

3

8

Small-scale

0.647

High

700127

CWC22
Pre-mRNA-splicing factor CWC22

3

0

High-throughput

0.634

High

700122

CWC23
Pre-mRNA-splicing factor CWC23

2

1

High-throughput

0.621

High

672039

BUD31
Pre-mRNA-splicing factor BUD31

1

2

High-throughput

0.618

High

700097

SLT11
Pre-mRNA-splicing factor SLT11

1

2

High-throughput

0.618

High

700080

BRR2
Pre-mRNA-splicing helicase BRR2

2

10

High-throughput

0.611

High

700157

PRP11
Pre-mRNA-splicing factor PRP11

2

1

High-throughput

0.601

High

700153

SP382
Pre-mRNA-splicing factor SPP382

2

0

Small-scale

0.596

High

700119

MDV1
Mitochondrial division protein 1

1

5

High-throughput

0.587

High

700168

EAF3
Chromatin modification-related protein EAF3

2

1

Small-scale

0.586

High

700126

SYF2
Pre-mRNA-splicing factor SYF2

1

0

High-throughput

0.586

High

700142

CWC15
Pre-mRNA-splicing factor CWC15

1

0

High-throughput

0.586

High

700147

SN309
Pre-mRNA-splicing factor SNT309

2

0

High-throughput

0.585

High

628191

PRP2
Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2

2

8

High-throughput

0.584

High

700088

NCBP1
Nuclear cap-binding protein complex subunit 1

2

1

High-throughput

0.584

High

700105

RSMB
Small nuclear ribonucleoprotein-associated protein B

2

1

High-throughput

0.584

High

700152

ATG17
Autophagy-related protein 17

2

0

High-throughput

0.565

High

700139

CWC21
Pre-mRNA-splicing factor CWC21

2

0

Small-scale

0.559

High

700073

XPO1
Exportin-1

1

1

High-throughput

0.536

High

700154

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.513

High

700144

ZWINT
Outer kinetochore KNL1 complex subunit KRE28

1

0

High-throughput

0.486

High

609043

SKI3
Superkiller protein 3

1

4

Small-scale

0.481

High

665785

KPC1
Protein kinase C-like 1

1

2

Small-scale

0.481

High

700074

RAD16
DNA repair protein RAD16

1

9

Small-scale

0.481

High

700089

SGS1
ATP-dependent helicase SGS1

1

5

Small-scale

0.481

High

700108

ATAD2
ATPase histone chaperone YTA7

1

2

Small-scale

0.481

High

700129

VPS75
Vacuolar protein sorting-associated protein 75

1

1

Small-scale

0.481

High

590179

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

1

8

High-throughput

0.479

High

625069

PRP9
Pre-mRNA-splicing factor PRP9

1

1

High-throughput

0.479

High

638047

ISY1
Pre-mRNA-splicing factor ISY1

1

2

High-throughput

0.479

High

700107

RUXG
Small nuclear ribonucleoprotein G

1

2

High-throughput

0.479

High

700110

IST3
U2 snRNP component IST3

1

4

High-throughput

0.479

High

700115

SMD3
Small nuclear ribonucleoprotein Sm D3

1

4

High-throughput

0.479

High

700132

RUXF
Small nuclear ribonucleoprotein F

1

1

High-throughput

0.479

High

700136

CUS1
Cold sensitive U2 snRNA suppressor 1

1

1

High-throughput

0.479

High

700160

NCBP2
Nuclear cap-binding protein subunit 2

1

3

High-throughput

0.479

High

700164

SCC1
Sister chromatid cohesion protein 1

1

1

High-throughput

0.479

High

700170

HSH49
Protein HSH49

1

4

High-throughput

0.479

High

368225

TRP
Tryptophan synthase

1

0

Small-scale

0.460

High

700075

NGG1
SAGA complex subunit NGG1

1

0

Small-scale

0.460

High

700083

TYE7
Transcription factor TYE7

1

0

High-throughput

0.460

High

700114

GSM1
Glucose starvation modulator protein 1

1

0

Small-scale

0.460

High

700125

ENV11
Late endosome and vacuole interface protein 11

1

0

Small-scale

0.460

High

700131

NIS1
Protein NIS1

1

0

Small-scale

0.460

High

700138

ECM5
Protein ECM5

1

0

Small-scale

0.460

High

700149

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

Small-scale

0.460

High

700165

SIZ2
E3 SUMO-protein ligase SIZ2

1

0

Small-scale

0.460

High

700169

AHC1
Protein AHC1

1

0

Small-scale

0.460

High

646321

RAD53
Serine/threonine-protein kinase RAD53

1

0

High-throughput

0.458

High

700079

RU1A
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.458

High

700092

NTR2
Pre-mRNA-splicing factor NTR2

1

0

High-throughput

0.458

High

700093

YK21
Uncharacterized protein YKR041W

1

0

High-throughput

0.458

High

700098

NTC20
Pre-mRNA-splicing factor NTC20

1

0

High-throughput

0.458

High

700100

WSS1
DNA-dependent metalloprotease WSS1

1

0

Small-scale

0.458

High

700103

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.458

High

700111

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

700116

CWC26
Pre-mRNA-splicing factor CWC26

1

0

High-throughput

0.458

High

700130

CWC25
Pre-mRNA-splicing factor CWC25

1

0

High-throughput

0.458

High

700133

SMD1
Small nuclear ribonucleoprotein Sm D1

1

0

High-throughput

0.458

High

700135

SPP2
Pre-mRNA-splicing factor SPP2

1

0

High-throughput

0.458

High

700137

SLU7
Pre-mRNA-splicing factor SLU7

1

0

High-throughput

0.458

High

700150

SMD2
Small nuclear ribonucleoprotein Sm D2

1

0

High-throughput

0.458

High

700156

RDS3
Pre-mRNA-splicing factor RDS3

1

0

High-throughput

0.458

High

700095

IMB2
Importin subunit beta-2

1

4

High-throughput

0.457

High

392347

HSP82
ATP-dependent molecular chaperone HSP82

1

3

High-throughput

0.445

High

403389

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

3

High-throughput

0.445

High

526087

HSP72
Heat shock protein SSA2

1

3

High-throughput

0.445

High

700078

HSP7F
Heat shock protein homolog SSE1

1

4

High-throughput

0.445

High

691596

AP2B
AP-2 complex subunit beta

1

4

Small-scale

0.439

High

700081

SEC6
Exocyst complex component SEC6

1

1

Small-scale

0.439

High

700085

SLA2
Protein SLA2

1

6

Small-scale

0.439

High

700087

NIP80
Protein NIP100

1

3

High-throughput

0.439

High

700090

DYHC
Dynein heavy chain, cytoplasmic

1

1

Small-scale

0.439

High

700094

CDC27
Anaphase-promoting complex subunit CDC27

1

4

Small-scale

0.439

High

700101

AP18A
Clathrin coat assembly protein AP180A

1

4

Small-scale

0.439

High

700113

BNI1
Protein BNI1

1

3

Small-scale

0.439

High

700146

EIS1
Eisosome protein 1

1

1

Small-scale

0.439

High

700117

YPP1
Cargo-transport protein YPP1

1

0

High-throughput

0.438

High

700159

SOG2
Leucine-rich repeat-containing protein SOG2

1

3

High-throughput

0.417

High

700104

TCPG
T-complex protein 1 subunit gamma

1

5

High-throughput

0.407

High

700148

YL345
Putative 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase YLR345W [Includes: 6-phosphofructo-2-kinase

3

0

High-throughput

0.337

High

700099

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.279

Low

654765

URE2
Transcriptional regulator URE2

1

0

High-throughput

0.265

Low

700096

FL2D
Protein MUM2

1

0

High-throughput

0.251

Low

700102

PUR4
Phosphoribosylformylglycinamidine synthase

1

0

Small-scale

0.251

Low

700106

FIR1
Factor interacting with REF2

1

0

Small-scale

0.251

Low

700109

MNN14
Mannosyltransferase regulator 14

1

0

Small-scale

0.251

Low

700118

DAS1
F-box protein DAS1

1

0

Small-scale

0.251

Low

700121

NU188
Nucleoporin NUP188

1

0

Small-scale

0.251

Low

700123

NUP84
Nucleoporin NUP84

1

0

Small-scale

0.251

Low

700128

MNT4
Probable alpha-1,3-mannosyltransferase MNT4

1

0

Small-scale

0.251

Low

700140

RMD1
Sporulation protein RMD1

1

0

Small-scale

0.251

Low

700151

SKG3
Protein SKG3

1

0

Small-scale

0.251

Low

700155

VAC14
Vacuole morphology and inheritance protein 14

1

0

Small-scale

0.251

Low

700158

UBR2
E3 ubiquitin-protein ligase UBR2

1

0

Small-scale

0.251

Low

700163

YG11A
Transposon Ty1-GR1 Gag polyprotein

1

0

High-throughput

0.249

Low

700082

PEP12
Syntaxin PEP12

1

0

High-throughput

0.238

Low

700086

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025