Interactor 1: MED21 (P47822)
Mediator of RNA polymerase II transcription subunit 21 (Mediator complex subunit 21) (RNAPII complex component SRB7) (Suppressor of RNA polymerase B 7)
Gene: SRB7

Interactor 2: MED7 (Q08278)
Mediator of RNA polymerase II transcription subunit 7 (Mediator complex subunit 7)
Gene: MED7

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.983

The method score is based on:

Property Details
Experiments 10688190, 11805826, 11555651, 15477388, 16758199, 37968396, 21498544, 9420330, 16554755, 16429126, 15710619, 26317468, 28575439, 19057509, 20123732
Identification Methods two hybrid, tandem affinity purification, affinity chromatography technology, biochemical, x-ray crystallography
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Med21~Med7
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0016592 - mediator complex
and 5 others

more...

Homologous interactions 1

Homologous interactions

Color coding for hit scores

1 140
Sc

1 222
+ Ca

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024