Protein: ISY1
Pre-mRNA-splicing factor ISY1 (Interactor of SYF1) (PRP19-associated complex protein 30)

Gene: ISY1
Organism: Saccharomyces cerevisiae S288C
Interactions: 55
UniProt ID: P21374

Gene Ontology (top 5):
GO:0000350 - generation of catalytic spliceosome for second transesterification step
GO:0000389 - mRNA 3'-splice site recognition
GO:0000398 - mRNA splicing, via spliceosome
GO:0000974 - Prp19 complex
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

638091

CWC2
Pre-mRNA-splicing factor CWC2

3

2

High-throughput

0.847

High

638093

PRP46
Pre-mRNA-splicing factor PRP46

2

2

High-throughput

0.789

High

638082

SYF1
Pre-mRNA-splicing factor SYF1

10

6

Small-scale

0.761

High

638051

PRP19
Pre-mRNA-processing factor 19

12

3

Small-scale

0.758

High

638048

YJU2
Splicing factor YJU2

2

2

Small-scale

0.754

High

638092

CLF1
Pre-mRNA-splicing factor CLF1

6

6

Small-scale

0.740

High

638080

CEF1
Pre-mRNA-splicing factor CEF1

4

2

Small-scale

0.698

High

638090

RU2A
U2 small nuclear ribonucleoprotein A'

4

2

Small-scale

0.683

High

638059

NTC20
Pre-mRNA-splicing factor NTC20

3

0

Small-scale

0.622

High

638054

PRP8
Pre-mRNA-splicing factor 8

1

3

High-throughput

0.618

High

638065

PRP17
Pre-mRNA-processing factor 17

1

4

High-throughput

0.618

High

638053

BRR2
Pre-mRNA-splicing helicase BRR2

2

5

High-throughput

0.611

High

638044

ISY1
Pre-mRNA-splicing factor ISY1

2

1

Small-scale

0.609

High

638070

SYF2
Pre-mRNA-splicing factor SYF2

2

0

Small-scale

0.595

High

638057

NTR2
Pre-mRNA-splicing factor NTR2

2

0

Small-scale

0.585

High

638084

SN309
Pre-mRNA-splicing factor SNT309

2

0

High-throughput

0.585

High

590176

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

2

4

Small-scale

0.584

High

628188

PRP2
Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2

2

4

High-throughput

0.584

High

638061

RSMB
Small nuclear ribonucleoprotein-associated protein B

2

2

High-throughput

0.584

High

638089

NCBP2
Nuclear cap-binding protein subunit 2

2

2

High-throughput

0.584

High

638086

SP382
Pre-mRNA-splicing factor SPP382

2

0

Small-scale

0.576

High

638079

CWC21
Pre-mRNA-splicing factor CWC21

2

0

Small-scale

0.559

High

638072

CWC25
Pre-mRNA-splicing factor CWC25

2

0

High-throughput

0.547

High

638050

XPO1
Exportin-1

1

1

High-throughput

0.536

High

638060

PRP39
Pre-mRNA-processing factor 39

1

6

Small-scale

0.481

High

638045

PRP22
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22

1

4

High-throughput

0.479

High

638046

BUD31
Pre-mRNA-splicing factor BUD31

1

2

High-throughput

0.479

High

638047

PRP45
Pre-mRNA-processing protein 45

1

2

High-throughput

0.479

High

638052

PRP21
Pre-mRNA-splicing factor PRP21

1

1

High-throughput

0.479

High

638056

SN114
Pre-mRNA-splicing factor SNU114

1

3

High-throughput

0.479

High

638058

SLT11
Pre-mRNA-splicing factor SLT11

1

1

High-throughput

0.479

High

638063

RUXG
Small nuclear ribonucleoprotein G

1

3

High-throughput

0.479

High

638064

MSL1
U2 small nuclear ribonucleoprotein B''

1

3

High-throughput

0.479

High

638066

SMD3
Small nuclear ribonucleoprotein Sm D3

1

2

High-throughput

0.479

High

638073

RUXF
Small nuclear ribonucleoprotein F

1

1

High-throughput

0.479

High

638083

RSE1
Pre-mRNA-splicing factor RSE1

1

1

High-throughput

0.479

High

625064

PRP9
Pre-mRNA-splicing factor PRP9

1

0

High-throughput

0.458

High

638055

NCBP1
Nuclear cap-binding protein complex subunit 1

1

0

High-throughput

0.458

High

638067

CWC26
Pre-mRNA-splicing factor CWC26

1

0

High-throughput

0.458

High

638069

SF3B1
U2 snRNP component HSH155

1

0

High-throughput

0.458

High

638071

CWC22
Pre-mRNA-splicing factor CWC22

1

0

High-throughput

0.458

High

638074

SMD1
Small nuclear ribonucleoprotein Sm D1

1

0

High-throughput

0.458

High

638075

SPP2
Pre-mRNA-splicing factor SPP2

1

0

High-throughput

0.458

High

638076

CUS1
Cold sensitive U2 snRNA suppressor 1

1

0

High-throughput

0.458

High

638077

SLU7
Pre-mRNA-splicing factor SLU7

1

0

High-throughput

0.458

High

638078

XRN2
5'-3' exoribonuclease 2

1

0

Small-scale

0.458

High

638081

CWC15
Pre-mRNA-splicing factor CWC15

1

0

High-throughput

0.458

High

638085

SMD2
Small nuclear ribonucleoprotein Sm D2

1

0

High-throughput

0.458

High

638087

RDS3
Pre-mRNA-splicing factor RDS3

1

0

High-throughput

0.458

High

638088

PRP11
Pre-mRNA-splicing factor PRP11

1

0

High-throughput

0.458

High

638094

HSH49
Protein HSH49

1

0

High-throughput

0.458

High

638062

SSB2
Ribosome-associated molecular chaperone SSB2

1

0

High-throughput

0.426

High

638068

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.426

High

638049

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025