HitPredict

Interactor 1: ID4 (P47928)
DNA-binding protein inhibitor ID-4 (Class B basic helix-loop-helix protein 27) (bHLHb27) (Inhibitor of DNA binding 4) (Inhibitor of differentiation 4)
Gene: ID4

Interactor 2: ID2 (Q02363)
DNA-binding protein inhibitor ID-2 (Class B basic helix-loop-helix protein 26) (bHLHb26) (Inhibitor of DNA binding 2) (Inhibitor of differentiation 2)
Gene: ID2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

The method score is based on:

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0010628 - positive regulation of gene expression and 6 others more... GO:0030154 - cell differentiation GO:0032922 - circadian regulation of gene expression GO:0045892 - negative regulation of DNA-templated transcription GO:0046983 - protein dimerization activity GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding GO:0140416 - transcription regulator inhibitor activity
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	161
Hs

1	134

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024