Protein: VPS52
Vacuolar protein sorting-associated protein 52 homolog (SAC2 suppressor of actin mutations 2-like protein)

Gene: VPS52
Organism: Homo sapiens
Interactions: 210
UniProt ID: Q8N1B4

Gene Ontology (top 5):
GO:0000938 - GARP complex
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol
GO:0006605 - protein targeting
GO:0006896 - Golgi to vacuole transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1323343

RNF41
E3 ubiquitin-protein ligase NRDP1

8

4

Small-scale

0.757

High

1323325

VPS50
Syndetin

6

6

Small-scale

0.738

High

821149

TXLNA
Alpha-taxilin

4

2

High-throughput

0.704

High

1323357

TB22B
TBC1 domain family member 22B

4

3

High-throughput

0.698

High

1200046

EIPR1
EARP and GARP complex-interacting protein 1

4

2

Small-scale

0.694

High

1323370

VPS51
Vacuolar protein sorting-associated protein 51 homolog

4

7

Small-scale

0.690

High

1217265

VPS53
Vacuolar protein sorting-associated protein 53 homolog

4

4

Small-scale

0.683

High

288462

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

3

1

High-throughput

0.675

High

1323312

GOGA1
Golgin subfamily A member 1

3

2

High-throughput

0.675

High

1323380

TRAF6
TNF receptor-associated factor 6

3

4

High-throughput

0.675

High

1323382

VATD
V-type proton ATPase subunit D

3

2

High-throughput

0.675

High

774489

BASI
Basigin

3

1

High-throughput

0.667

High

630880

RAB4A
Ras-related protein Rab-4A

3

3

High-throughput

0.666

High

1323372

VPS28
Vacuolar protein sorting-associated protein 28 homolog

3

1

High-throughput

0.660

High

1185279

F161A
Protein FAM161A

3

1

High-throughput

0.650

High

1323365

VPS54
Vacuolar protein sorting-associated protein 54

3

2

Small-scale

0.646

High

684305

DDX6
Probable ATP-dependent RNA helicase DDX6

3

0

High-throughput

0.646

High

1323361

AIRIM
AFG2-interacting ribosome maturation factor

3

0

High-throughput

0.646

High

1323321

THA11
THAP domain-containing protein 11

2

1

High-throughput

0.633

High

935559

MFAP1
Microfibrillar-associated protein 1

3

1

High-throughput

0.616

High

1239712

PPR18
Phostensin

3

1

High-throughput

0.616

High

1314893

CC146
Coiled-coil domain-containing protein 146

3

1

High-throughput

0.616

High

1323330

TSSK3
Testis-specific serine/threonine-protein kinase 3

3

1

High-throughput

0.616

High

1116762

AAMP
Angio-associated migratory cell protein

2

1

High-throughput

0.613

High

164011

NDC80
Kinetochore protein NDC80 homolog

2

1

High-throughput

0.606

High

956221

RAB4B
Ras-related protein Rab-4B

2

3

High-throughput

0.606

High

1243017

PKN3
Serine/threonine-protein kinase N3

2

1

High-throughput

0.606

High

1287242

TBCD1
TBC1 domain family member 1

2

2

High-throughput

0.606

High

1323294

TXLNB
Beta-taxilin

2

6

High-throughput

0.606

High

1323306

LNX1
E3 ubiquitin-protein ligase LNX

2

1

High-throughput

0.606

High

1323308

CCHCR
Coiled-coil alpha-helical rod protein 1

2

2

High-throughput

0.606

High

1323316

JKIP2
Janus kinase and microtubule-interacting protein 2

2

1

High-throughput

0.606

High

1323332

CDC5L
Cell division cycle 5-like protein

2

1

High-throughput

0.606

High

1323338

TRAF4
TNF receptor-associated factor 4

2

3

High-throughput

0.606

High

1323339

KIFC3
Kinesin-like protein KIFC3

2

2

High-throughput

0.606

High

1323362

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

2

1

High-throughput

0.606

High

968988

PRS8
26S proteasome regulatory subunit 8

2

0

High-throughput

0.602

High

1323369

ENOPH
Enolase-phosphatase E1

2

0

High-throughput

0.602

High

1151483

IKBB
NF-kappa-B inhibitor beta

2

0

High-throughput

0.601

High

1323377

NINL
Ninein-like protein

2

2

High-throughput

0.584

High

221268

DCX
Neuronal migration protein doublecortin

2

0

High-throughput

0.580

High

478698

HXB5
Homeobox protein Hox-B5

2

0

High-throughput

0.580

High

941015

HDAC4
Histone deacetylase 4

2

0

High-throughput

0.580

High

1118918

BYST
Bystin

2

0

High-throughput

0.580

High

1323326

CEP19
Centrosomal protein of 19 kDa

2

0

High-throughput

0.580

High

1323335

F110A
Protein FAM110A

2

0

High-throughput

0.580

High

1323349

GORS2
Golgi reassembly-stacking protein 2

2

0

High-throughput

0.580

High

1323354

CABP5
Calcium-binding protein 5

2

0

High-throughput

0.580

High

1323366

KLH42
Kelch-like protein 42

2

0

High-throughput

0.580

High

1323379

WASC3
WASH complex subunit 3

2

0

High-throughput

0.580

High

286681

STX11
Syntaxin-11

1

2

High-throughput

0.573

High

447808

TPM3
Tropomyosin alpha-3 chain

1

2

High-throughput

0.573

High

930752

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

1

High-throughput

0.573

High

1095413

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

1

High-throughput

0.573

High

1150207

TEAD4
Transcriptional enhancer factor TEF-3

2

1

High-throughput

0.559

High

262405

DTNB
Dystrobrevin beta

2

1

High-throughput

0.553

High

933863

GEM
GTP-binding protein GEM

2

2

High-throughput

0.553

High

1057632

CDK18
Cyclin-dependent kinase 18

2

1

High-throughput

0.553

High

1314926

CCD13
Coiled-coil domain-containing protein 13

2

1

High-throughput

0.553

High

1323298

CC185
Coiled-coil domain-containing protein 185

2

2

High-throughput

0.553

High

1323304

CA216
UPF0500 protein C1orf216

2

1

High-throughput

0.553

High

1323305

ZN417
Zinc finger protein 417

2

1

High-throughput

0.553

High

1323328

F161B
Protein FAM161B

2

1

High-throughput

0.553

High

1323331

ZN587
Zinc finger protein 587

2

1

High-throughput

0.553

High

1323350

KIF9
Kinesin-like protein KIF9

2

4

High-throughput

0.553

High

1323360

DJC11
DnaJ homolog subfamily C member 11

2

3

High-throughput

0.553

High

1178846

CF184
Cilia- and flagella-associated protein 184

2

1

High-throughput

0.549

High

1323297

EFNMT
eEF1A lysine and N-terminal methyltransferase

1

0

High-throughput

0.549

High

1323319

HAUS1
HAUS augmin-like complex subunit 1

1

0

High-throughput

0.549

High

1323347

SH24A
SH2 domain-containing protein 4A

1

0

High-throughput

0.549

High

169652

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

2

High-throughput

0.541

High

182653

GP182
G-protein coupled receptor 182

1

7

High-throughput

0.536

High

252884

EXOC3
Exocyst complex component 3

1

3

High-throughput

0.536

High

688706

NKG2D
NKG2-D type II integral membrane protein

1

3

High-throughput

0.536

High

1144851

RABE1
Rab GTPase-binding effector protein 1

1

3

High-throughput

0.536

High

1258641

IKIP
Inhibitor of nuclear factor kappa-B kinase-interacting protein

1

1

High-throughput

0.536

High

1323334

CML1
Chemerin-like receptor 1

1

6

High-throughput

0.536

High

855132

NOP2
28S rRNA

1

1

High-throughput

0.523

High

1213004

SKT
Sickle tail protein homolog

1

1

High-throughput

0.523

High

691792

MK03
Mitogen-activated protein kinase 3

1

0

High-throughput

0.518

High

1200645

Q548N1
Vacuolar protein sorting-associated protein 28 homolog

1

1

High-throughput

0.515

High

1323383

V9HW29
Kinesin-like protein

1

6

High-throughput

0.515

High

187135

PPM1G
Protein phosphatase 1G

1

0

High-throughput

0.513

High

854159

KI67
Proliferation marker protein Ki-67

1

0

High-throughput

0.513

High

1053030

VMAT2
Synaptic vesicular amine transporter

1

0

High-throughput

0.513

High

1323310

AQP3
Aquaporin-3

1

0

High-throughput

0.513

High

1323356

GTR9
Solute carrier family 2, facilitated glucose transporter member 9

1

0

High-throughput

0.513

High

1323364

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

0

High-throughput

0.513

High

1323353

ARNT2
Aryl hydrocarbon receptor nuclear translocator 2

1

1

High-throughput

0.494

High

914295

EFNA4
Ephrin-A4

1

1

High-throughput

0.489

High

956937

CXCR4
C-X-C chemokine receptor type 4

1

6

High-throughput

0.489

High

1101579

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

4

High-throughput

0.489

High

1323301

THAP8
THAP domain-containing protein 8

1

4

High-throughput

0.489

High

1323309

CLC2B
C-type lectin domain family 2 member B

1

3

High-throughput

0.489

High

1323327

ODAD1
Outer dynein arm-docking complex subunit 1

1

1

High-throughput

0.489

High

1323336

KXDL1
KxDL motif-containing protein 1

1

1

High-throughput

0.489

High

139725

CAC1A
Voltage-dependent P/Q-type calcium channel subunit alpha-1A

1

0

High-throughput

0.486

High

749963

KINH
Kinesin-1 heavy chain

1

6

High-throughput

0.481

High

1323293

VPS52
Vacuolar protein sorting-associated protein 52 homolog

1

3

Small-scale

0.481

High

1323302

F184A
Protein FAM184A

1

3

High-throughput

0.481

High

1323344

HEAT1
HEAT repeat-containing protein 1

1

1

High-throughput

0.481

High

1323345

RABE2
Rab GTPase-binding effector protein 2

1

3

High-throughput

0.481

High

173057

XPO1
Exportin-1

1

1

High-throughput

0.479

High

226125

STX6
Syntaxin-6

1

1

Small-scale

0.479

High

242255

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

278529

VAMP4
Vesicle-associated membrane protein 4

1

1

Small-scale

0.479

High

372552

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

412243

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

791524

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

955365

CDC42
Cell division control protein 42 homolog

1

3

High-throughput

0.479

High

962256

RHOA
Transforming protein RhoA

1

4

High-throughput

0.479

High

988518

RAC1
Ras-related C3 botulinum toxin substrate 1

1

3

High-throughput

0.479

High

1141777

EEA1
Early endosome antigen 1

1

1

High-throughput

0.479

High

1146435

KS6A2
Ribosomal protein S6 kinase alpha-2

1

1

High-throughput

0.479

High

1148360

KS6A1
Ribosomal protein S6 kinase alpha-1

1

1

High-throughput

0.479

High

1323351

RHOF
Rho-related GTP-binding protein RhoF

1

5

High-throughput

0.479

High

1323355

DBLOH
Diablo IAP-binding mitochondrial protein

1

1

High-throughput

0.479

High

1323363

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

1323367

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

91677

C9JG97
Angio-associated migratory cell protein

1

1

High-throughput

0.470

High

92352

D3DUQ6
TEA domain family member 4 isoform 1

1

1

High-throughput

0.470

High

1218092

Q5VU62
TPM3 protein

1

1

High-throughput

0.470

High

1243410

Q6P9G8
Family with sequence similarity 184, member A

1

1

High-throughput

0.470

High

1244998

Q6PJ05
V-type proton ATPase subunit D

1

2

High-throughput

0.470

High

1323296

Q8N5Z9
V-type proton ATPase subunit D

1

2

High-throughput

0.470

High

1323322

Q96ES5
HEAT repeat-containing protein 1

1

1

High-throughput

0.470

High

138212

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

0

High-throughput

0.458

High

278894

PEX14
Peroxisomal membrane protein PEX14

1

0

High-throughput

0.458

High

1178245

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1276211

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.458

High

1323317

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

0

High-throughput

0.458

High

1323318

VP33A
Vacuolar protein sorting-associated protein 33A

1

0

High-throughput

0.458

High

1323373

SMC3
Structural maintenance of chromosomes protein 3

1

0

High-throughput

0.458

High

634781

GRAH
Granzyme H

1

1

High-throughput

0.445

High

679374

DNJB2
DnaJ homolog subfamily B member 2

1

2

High-throughput

0.445

High

1323303

DNJB8
DnaJ homolog subfamily B member 8

1

2

High-throughput

0.445

High

1323368

CLC2D
C-type lectin domain family 2 member D

1

3

High-throughput

0.445

High

174556

TRI66
Tripartite motif-containing protein 66

1

2

High-throughput

0.437

High

342249

BRD1
Bromodomain-containing protein 1

1

1

High-throughput

0.437

High

406381

MYCN
N-myc proto-oncogene protein

1

2

High-throughput

0.437

High

589135

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

695921

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

768628

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

1004813

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.437

High

1254602

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

1323300

ARL10
ADP-ribosylation factor-like protein 10

1

1

High-throughput

0.437

High

1323311

ESR2
Estrogen receptor beta

1

1

High-throughput

0.437

High

1323342

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

457549

TBB5
Tubulin beta chain

1

0

High-throughput

0.426

High

1239240

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.426

High

1323323

AURKB
Aurora kinase B

1

0

High-throughput

0.426

High

1323346

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.426

High

1323348

ZDH11
Palmitoyltransferase ZDHHC11

1

0

High-throughput

0.426

High

1323376

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

0

High-throughput

0.426

High

3387

A0A0S2Z4Q4
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

2

High-throughput

0.417

High

1323371

TRIM1
Probable E3 ubiquitin-protein ligase MID2

1

3

High-throughput

0.417

High

754062

CD80
T-lymphocyte activation antigen CD80

1

1

High-throughput

0.407

High

886099

CXCR3
C-X-C chemokine receptor type 3

1

5

High-throughput

0.407

High

1323307

TBC15
TBC1 domain family member 15

1

3

High-throughput

0.407

High

1136466

FL2D
Pre-mRNA-splicing regulator WTAP

4

0

High-throughput

0.365

High

1214457

TSTD2
Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2

3

0

High-throughput

0.352

High

1272776

EPMIP
EPM2A-interacting protein 1

3

0

High-throughput

0.352

High

1323299

TEANC
Transcription elongation factor A N-terminal and central domain-containing protein

3

0

High-throughput

0.352

High

1323333

THIOM
Thioredoxin, mitochondrial

3

0

High-throughput

0.352

High

635430

C4BPB
C4b-binding protein beta chain

3

0

High-throughput

0.347

High

1156937

CNGA3
Cyclic nucleotide-gated channel alpha-3

3

0

High-throughput

0.345

High

1323324

BORC6
BLOC-1-related complex subunit 6

3

0

High-throughput

0.340

High

821743

CD79B
B-cell antigen receptor complex-associated protein beta chain

2

0

High-throughput

0.328

High

1101281

SLAF1
Signaling lymphocytic activation molecule

2

0

High-throughput

0.318

High

1323320

FAF2
FAS-associated factor 2

2

0

High-throughput

0.318

High

1055244

MTG8
Protein CBFA2T1

2

0

High-throughput

0.316

High

1120683

VEZF1
Vascular endothelial zinc finger 1

2

0

High-throughput

0.316

High

1179980

CCD57
Coiled-coil domain-containing protein 57

2

0

High-throughput

0.316

High

1180463

C19L2
CWF19-like protein 2

2

0

High-throughput

0.316

High

1198818

ZC21C
Zinc finger C2HC domain-containing protein 1C

2

0

High-throughput

0.316

High

1200576

CTSRT
Cation channel sperm-associated targeting subunit tau

2

0

High-throughput

0.316

High

1228679

C102B
Coiled-coil domain-containing protein 102B

2

0

High-throughput

0.316

High

1273055

OTU6A
OTU domain-containing protein 6A

2

0

High-throughput

0.316

High

1292636

NR2CA
Nuclear receptor 2C2-associated protein

2

0

High-throughput

0.316

High

1294637

CD20B
Cell division cycle protein 20 homolog B

2

0

High-throughput

0.316

High

1309192

Q8IVT4
Hypothetical MGC50722

2

0

High-throughput

0.316

High

1315365

CF206
Cilia- and flagella-associated protein 206

2

0

High-throughput

0.316

High

1323313

GPKOW
G-patch domain and KOW motifs-containing protein

2

0

High-throughput

0.316

High

1323314

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

2

0

High-throughput

0.316

High

1323340

SCNM1
Sodium channel modifier 1

2

0

High-throughput

0.316

High

1323341

RM01
Large ribosomal subunit protein uL1m

2

0

High-throughput

0.316

High

1323358

T11L1
T-complex protein 11-like protein 1

2

0

High-throughput

0.316

High

1323374

FA50B
Protein FAM50B

2

0

High-throughput

0.316

High

965486

LMO4
LIM domain transcription factor LMO4

1

0

High-throughput

0.299

High

1225002

KANK2
KN motif and ankyrin repeat domain-containing protein 2

1

0

High-throughput

0.299

High

1242674

KLC3
Kinesin light chain 3

1

0

High-throughput

0.299

High

1323315

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

0

High-throughput

0.299

High

1323329

ZMAT2
Zinc finger matrin-type protein 2

1

0

High-throughput

0.299

High

1323378

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.299

High

1323337

PIMRE
Protein PIMREG

1

0

High-throughput

0.282

High

553430

FCERA
High affinity immunoglobulin epsilon receptor subunit alpha

1

0

High-throughput

0.279

Low

1179813

INSY1
Inhibitory synaptic factor 1

1

0

High-throughput

0.279

Low

1323352

SACA1
Sperm acrosome membrane-associated protein 1

1

0

High-throughput

0.279

Low

1323375

PSF2
DNA replication complex GINS protein PSF2

1

0

High-throughput

0.279

Low

1323381

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

High-throughput

0.279

Low

1323295

CCD33
Coiled-coil domain-containing protein 33

1

0

High-throughput

0.251

Low

106251

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

879263

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

1249009

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1276472

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1323359

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.249

Low

295605

CIB2
Calcium and integrin-binding family member 2

1

0

High-throughput

0.232

Low

628426

KLK2
Kallikrein-2

1

0

High-throughput

0.232

Low

1247268

WDR74
WD repeat-containing protein 74

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025