Protein: VPS53
Vacuolar protein sorting-associated protein 53 homolog

Gene: VPS53
Organism: Homo sapiens
Interactions: 100
UniProt ID: Q5VIR6

Gene Ontology (top 5):
GO:0000938 - GARP complex
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol
GO:0006622 - protein targeting to lysosome
GO:0007041 - lysosomal transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1217274

VPS50
Syndetin

7

6

Small-scale

0.751

High

1217290

VPS54
Vacuolar protein sorting-associated protein 54

5

3

Small-scale

0.718

High

1200035

EIPR1
EARP and GARP complex-interacting protein 1

5

1

Small-scale

0.714

High

1217293

VPS51
Vacuolar protein sorting-associated protein 51 homolog

4

2

Small-scale

0.687

High

1217265

VPS52
Vacuolar protein sorting-associated protein 52 homolog

4

4

Small-scale

0.683

High

1217273

DTBP1
Dysbindin

4

0

High-throughput

0.661

High

343388

SNP29
Synaptosomal-associated protein 29

3

0

High-throughput

0.638

High

774405

BASI
Basigin

3

0

High-throughput

0.638

High

906539

PSMD7
26S proteasome non-ATPase regulatory subunit 7

3

0

High-throughput

0.638

High

1217267

EXOC6
Exocyst complex component 6

2

0

High-throughput

0.602

High

1217288

EXOC1
Exocyst complex component 1

2

0

High-throughput

0.602

High

226065

STX6
Syntaxin-6

2

1

Small-scale

0.584

High

182574

GP182
G-protein coupled receptor 182

1

1

High-throughput

0.536

High

300660

KRT37
Keratin, type I cuticular Ha7

1

1

High-throughput

0.536

High

300770

KRT38
Keratin, type I cuticular Ha8

1

1

High-throughput

0.536

High

1210867

CE170
Centrosomal protein of 170 kDa

1

1

High-throughput

0.536

High

1217279

CML1
Chemerin-like receptor 1

1

1

High-throughput

0.536

High

257636

PRAF2
PRA1 family protein 2

1

0

High-throughput

0.513

High

854104

KI67
Proliferation marker protein Ki-67

1

0

High-throughput

0.513

High

1217289

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

0

High-throughput

0.513

High

1217296

BL1S6
Biogenesis of lysosome-related organelles complex 1 subunit 6

1

0

High-throughput

0.513

High

1217282

VP33B
Vacuolar protein sorting-associated protein 33B

1

0

High-throughput

0.493

High

1217275

EXOC2
Exocyst complex component 2

1

2

Small-scale

0.481

High

132733

BMAL1
Basic helix-loop-helix ARNT-like protein 1

1

1

High-throughput

0.479

High

192932

CLOCK
Circadian locomoter output cycles protein kaput

1

1

High-throughput

0.479

High

562115

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.479

High

630833

RAB4A
Ras-related protein Rab-4A

1

3

High-throughput

0.479

High

901863

RAB9A
Ras-related protein Rab-9A

1

1

High-throughput

0.479

High

956336

RAB2A
Ras-related protein Rab-2A

1

3

High-throughput

0.479

High

1217297

LAMP3
Lysosome-associated membrane glycoprotein 3

1

1

High-throughput

0.479

High

1217252

VPS53
Vacuolar protein sorting-associated protein 53 homolog

1

0

Small-scale

0.460

High

128441

PSMD9
26S proteasome non-ATPase regulatory subunit 9

1

0

High-throughput

0.458

High

189620

STX7
Syntaxin-7

1

0

High-throughput

0.458

High

217113

MS18B
Protein Mis18-beta

1

0

High-throughput

0.458

High

278512

VAMP4
Vesicle-associated membrane protein 4

1

0

Small-scale

0.458

High

299235

FLOT1
Flotillin-1

1

0

High-throughput

0.458

High

390610

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.458

High

437213

K2C8
Keratin, type II cytoskeletal 8

1

0

High-throughput

0.458

High

621659

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

934729

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

976323

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.458

High

1106573

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.458

High

1139207

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

0

High-throughput

0.458

High

1144826

RABE1
Rab GTPase-binding effector protein 1

1

0

High-throughput

0.458

High

1178190

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1196260

GRAP1
GRIP1-associated protein 1

1

0

High-throughput

0.458

High

1201119

CCD93
Coiled-coil domain-containing protein 93

1

0

High-throughput

0.458

High

1217256

CAVN1
Caveolae-associated protein 1

1

0

High-throughput

0.458

High

1217257

PKN3
Serine/threonine-protein kinase N3

1

0

High-throughput

0.458

High

1217260

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.458

High

1217261

HAUS6
HAUS augmin-like complex subunit 6

1

0

High-throughput

0.458

High

1217268

GOGA5
Golgin subfamily A member 5

1

0

High-throughput

0.458

High

1217269

CCHCR
Coiled-coil alpha-helical rod protein 1

1

0

High-throughput

0.458

High

1217270

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

0

High-throughput

0.458

High

1217272

THA11
THAP domain-containing protein 11

1

0

High-throughput

0.458

High

1217280

NUF2
Kinetochore protein Nuf2

1

0

High-throughput

0.458

High

1217287

BRD7
Bromodomain-containing protein 7

1

0

High-throughput

0.458

High

1217291

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1217294

RABX5
Rab5 GDP/GTP exchange factor

1

0

High-throughput

0.458

High

1217271

PF21A
PHD finger protein 21A

1

1

High-throughput

0.437

High

1217281

UN93B
Protein unc-93 homolog B1

1

1

High-throughput

0.437

High

1217283

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

166318

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

0

High-throughput

0.426

High

1217276

C170L
Cep170-like protein

1

1

High-throughput

0.407

High

50905

SYCE3
Synaptonemal complex central element protein 3

2

0

High-throughput

0.328

High

1194657

CCD40
Coiled-coil domain-containing protein 40

2

0

High-throughput

0.328

High

706159

S10A2
Protein S100-A2

1

0

High-throughput

0.279

Low

789138

NUP62
Nuclear pore glycoprotein p62

1

0

High-throughput

0.279

Low

914272

EFNA4
Ephrin-A4

1

0

High-throughput

0.279

Low

1101512

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

0

High-throughput

0.279

Low

1179791

INSY1
Inhibitory synaptic factor 1

1

0

High-throughput

0.279

Low

1217262

TXND2
Thioredoxin domain-containing protein 2

1

0

High-throughput

0.279

Low

1217264

ENTD1
ENTH domain-containing protein 1

1

0

High-throughput

0.279

Low

1217278

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.279

Low

1217298

PSF2
DNA replication complex GINS protein PSF2

1

0

High-throughput

0.279

Low

85275

RBG10
Rab GTPase-activating protein 1-like, isoform 10

1

0

High-throughput

0.249

Low

106088

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

139892

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

174526

TRI66
Tripartite motif-containing protein 66

1

0

High-throughput

0.249

Low

246660

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.249

Low

340344

YETS4
YEATS domain-containing protein 4

1

0

High-throughput

0.249

Low

503602

TFPT
TCF3 fusion partner

1

0

High-throughput

0.249

Low

959598

MAX
Protein max

1

0

High-throughput

0.249

Low

1027040

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.249

Low

1122401

GIT2
ARF GTPase-activating protein GIT2

1

0

High-throughput

0.249

Low

1217254

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.249

Low

1217255

PHLB3
Pleckstrin homology-like domain family B member 3

1

0

High-throughput

0.249

Low

1217258

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1217259

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1217263

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

0

High-throughput

0.249

Low

1217266

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

1217277

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

0

High-throughput

0.249

Low

1217284

NCK5L
Nck-associated protein 5-like

1

0

High-throughput

0.249

Low

1217285

TUFT1
Tuftelin

1

0

High-throughput

0.249

Low

1217286

HM20A
High mobility group protein 20A

1

0

High-throughput

0.249

Low

1217292

XPO7
Exportin-7

1

0

High-throughput

0.249

Low

1217295

RCOR1
REST corepressor 1

1

0

High-throughput

0.249

Low

1167059

WHAL1
Putative WASP homolog-associated protein with actin, membranes and microtubules-like protein 1

1

0

High-throughput

0.232

Low

1217253

ANR22
Ankyrin repeat domain-containing protein 22

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025