HitPredict

Interactor 1: SOX2 (P48431)
Transcription factor SOX-2
Gene: SOX2

Interactor 2: CBX2 (Q14781)
Chromobox protein homolog 2
Gene: CBX2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	23667531
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006325 - chromatin organization
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 317 Hs			1 532
+	Hs
		996672 SSRP1_HUMAN (24-203): 1.77e-31: 125: 15.68		CBX2_HUMAN (1-532): 6.32e-156: 457: 100.00
+	Hs
		123201 SOX2_HUMAN (1-317): 2.16e-77: 240: 100.00		CBX4_HUMAN (3-522): 6.17e-110: 340: 21.89
+	Mm
		818693 SOX2_MOUSE (1-317): 8.01e-72: 226: 94.67		CBX1_MOUSE (18-153): 1.81e-38: 141: 22.79
+	Mm
		818771 SOX2_MOUSE (1-317): 8.01e-72: 226: 94.67		Q9DCC5_MOUSE (9-152): 1.29e-37: 138: 21.53
+	Mm
		818718 SOX2_MOUSE (1-317): 8.01e-72: 226: 94.67		CBX5_MOUSE (12-152): 3.66e-35: 132: 25.34
+	Dm
		1363173 Q9VUD3_DROME (30-228): 1e-30: 123: 40.59		Q9VCU6_DROME (9-253): 3.96e-52: 179: 20.64
+	Hs
		996854 SSRP1_HUMAN (24-203): 1.77e-31: 125: 15.68		MPP8_HUMAN (7-397): 6.88e-47: 177: 17.54
+	Dm
		114467 M9PCG2_DROME (30-228): 7.05e-30: 120: 40.59		Q9VCU6_DROME (9-253): 3.96e-52: 179: 20.64
+	Hs
		727806 SOX5_HUMAN (2-127): 7.91e-43: 158: 41.27		CBX8_HUMAN (3-238): 1.39e-35: 139: 29.39
+	Hs
		316171 TF7L2_HUMAN (14-255): 5.81e-35: 135: 19.75		CBX6_HUMAN (3-242): 2.28e-36: 141: 30.29
+	Hs
		1027280 TF7L2_HUMAN (14-255): 5.81e-35: 135: 19.75		CBX3_HUMAN (9-152): 1.29e-37: 138: 21.53
+	Hs
		1027207 CIC_HUMAN (3-272): 8.9e-33: 130: 22.26		CBX3_HUMAN (9-152): 1.29e-37: 138: 21.53
+	Hs
		800501 CIC_HUMAN (3-272): 8.9e-33: 130: 22.26		CBX5_HUMAN (12-152): 1.24e-35: 133: 24.66
+	Hs
		996646 SSRP1_HUMAN (24-203): 1.77e-31: 125: 15.68		CBX3_HUMAN (9-152): 1.29e-37: 138: 21.53
+	Hs
		1027152 BBX_HUMAN (20-260): 9.07e-30: 121: 19.75		CBX3_HUMAN (9-152): 1.29e-37: 138: 21.53
+	Hs
		331801 NSD2_HUMAN (7-251): 1.34e-29: 120: 10.71		CBX3_HUMAN (9-152): 1.29e-37: 138: 21.53