Protein: SMD3
Small nuclear ribonucleoprotein Sm D3 (Sm-D3) (snRNP core protein D3)

Gene: SMD3
Organism: Saccharomyces cerevisiae S288C
Interactions: 93
UniProt ID: P43321

Gene Ontology (top 5):
GO:0000243 - commitment complex
GO:0000245 - spliceosomal complex assembly
GO:0000387 - spliceosomal snRNP assembly
GO:0000395 - mRNA 5'-splice site recognition
GO:0000398 - mRNA splicing, via spliceosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

817120

RSMB
Small nuclear ribonucleoprotein-associated protein B

8

16

Small-scale

0.964

High

751751

PRP8
Pre-mRNA-splicing factor 8

6

7

Small-scale

0.943

High

847821

SMD1
Small nuclear ribonucleoprotein Sm D1

5

8

Small-scale

0.922

High

820816

RUXG
Small nuclear ribonucleoprotein G

5

20

Small-scale

0.912

High

847804

LSM8
LSM2-LSM8 complex subunit LSM8

5

20

Small-scale

0.912

High

847813

RUXF
Small nuclear ribonucleoprotein F

5

20

Small-scale

0.912

High

847839

LUC7
Protein LUC7

4

2

High-throughput

0.896

High

847841

RU2A
U2 small nuclear ribonucleoprotein A'

4

11

Small-scale

0.886

High

847823

PRP3
U4/U6 small nuclear ribonucleoprotein PRP3

3

7

Small-scale

0.847

High

780186

SN114
Pre-mRNA-splicing factor SNU114

3

11

Small-scale

0.839

High

847834

SMD2
Small nuclear ribonucleoprotein Sm D2

3

13

Small-scale

0.839

High

847846

RUXE
Small nuclear ribonucleoprotein E

3

17

Small-scale

0.839

High

847832

RU1C
U1 small nuclear ribonucleoprotein C

4

0

Small-scale

0.836

High

818012

LSM4
LSM complex subunit LSM4

2

15

Small-scale

0.789

High

847835

LSM6
LSM complex subunit LSM6

2

20

Small-scale

0.789

High

625104

PRP9
Pre-mRNA-splicing factor PRP9

2

4

High-throughput

0.776

High

795883

LSM2
LSM complex subunit LSM2

2

16

Small-scale

0.754

High

847818

RU17
U1 small nuclear ribonucleoprotein 70 kDa homolog

2

14

High-throughput

0.754

High

744126

BRR2
Pre-mRNA-splicing helicase BRR2

7

20

Small-scale

0.742

High

847814

LSM3
LSM complex subunit LSM3

2

20

High-throughput

0.737

High

847822

CUS1
Cold sensitive U2 snRNA suppressor 1

5

4

High-throughput

0.714

High

847825

CEF1
Pre-mRNA-splicing factor CEF1

5

8

Small-scale

0.712

High

847816

NAM8
Protein NAM8

5

2

Small-scale

0.712

High

757500

NCBP1
Nuclear cap-binding protein complex subunit 1

4

2

High-throughput

0.691

High

847842

CWC2
Pre-mRNA-splicing factor CWC2

3

6

High-throughput

0.667

High

743529

RU1A
U1 small nuclear ribonucleoprotein A

4

0

Small-scale

0.664

High

750266

PRP40
Pre-mRNA-processing protein PRP40

3

6

High-throughput

0.662

High

625022

PRP6
Pre-mRNA-splicing factor 6

3

15

Small-scale

0.650

High

739155

PRP19
Pre-mRNA-processing factor 19

3

18

Small-scale

0.650

High

847806

PRP31
Pre-mRNA-processing factor 31

3

8

Small-scale

0.650

High

847849

SNU66
66 kDa U4/U6.U5 small nuclear ribonucleoprotein component

3

5

Small-scale

0.650

High

740963

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

3

8

High-throughput

0.643

High

847840

NCBP2
Nuclear cap-binding protein subunit 2

3

3

High-throughput

0.640

High

847809

SNU71
U1 small nuclear ribonucleoprotein component SNU71

3

0

Small-scale

0.634

High

847828

SNU56
56 kDa U1 small nuclear ribonucleoprotein component

3

0

High-throughput

0.634

High

847833

SN309
Pre-mRNA-splicing factor SNT309

3

0

High-throughput

0.634

High

813357

PRP39
Pre-mRNA-processing factor 39

2

20

High-throughput

0.601

High

847829

SYF1
Pre-mRNA-splicing factor SYF1

2

20

High-throughput

0.601

High

847831

RSE1
Pre-mRNA-splicing factor RSE1

2

5

High-throughput

0.601

High

847838

PRP11
Pre-mRNA-splicing factor PRP11

2

5

High-throughput

0.601

High

627854

PRP4
U4/U6 small nuclear ribonucleoprotein PRP4

2

18

Small-scale

0.584

High

847817

PRP38
Pre-mRNA-splicing factor 38

2

1

Small-scale

0.584

High

847837

DIB1
Spliceosomal protein DIB1

2

4

Small-scale

0.584

High

847845

CLF1
Pre-mRNA-splicing factor CLF1

2

20

Small-scale

0.584

High

847847

SNU23
23 kDa U4/U6.U5 small nuclear ribonucleoprotein component

2

1

Small-scale

0.584

High

702256

YJU2
Splicing factor YJU2

2

0

High-throughput

0.576

High

752399

HSP78
Heat shock protein 78, mitochondrial

2

1

High-throughput

0.571

High

847824

CWC21
Pre-mRNA-splicing factor CWC21

2

0

Small-scale

0.559

High

847808

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

6

High-throughput

0.536

High

847836

SP382
Pre-mRNA-splicing factor SPP382

1

0

High-throughput

0.513

High

724882

RAD16
DNA repair protein RAD16

1

4

High-throughput

0.508

High

802134

STB5
Protein STB5

1

1

High-throughput

0.508

High

847815

SEN1
Helicase SEN1

1

5

High-throughput

0.508

High

664600

PRP22
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22

1

7

Small-scale

0.501

High

847805

RL38
Large ribosomal subunit protein eL38

1

0

High-throughput

0.493

High

656325

PP2B1
Serine/threonine-protein phosphatase 2B catalytic subunit A1

1

0

High-throughput

0.486

High

737324

CDC12
Cell division control protein 12

1

0

High-throughput

0.486

High

807711

REV7
DNA polymerase zeta processivity subunit

1

0

High-throughput

0.486

High

847820

MTD1
Methylenetetrahydrofolate dehydrogenase [NAD(+)]

1

0

High-throughput

0.486

High

594426

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

Small-scale

0.479

High

638066

ISY1
Pre-mRNA-splicing factor ISY1

1

2

High-throughput

0.479

High

672059

BUD31
Pre-mRNA-splicing factor BUD31

1

1

High-throughput

0.479

High

700115

PRP45
Pre-mRNA-processing protein 45

1

4

High-throughput

0.479

High

707409

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.479

High

738866

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

3

High-throughput

0.479

High

739252

PRP21
Pre-mRNA-splicing factor PRP21

1

6

High-throughput

0.479

High

796447

SLT11
Pre-mRNA-splicing factor SLT11

1

2

High-throughput

0.479

High

812411

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.479

High

829941

PRP17
Pre-mRNA-processing factor 17

1

18

High-throughput

0.479

High

847807

SF3B1
U2 snRNP component HSH155

1

7

High-throughput

0.479

High

847810

EIF2A
Eukaryotic translation initiation factor 2A

1

2

High-throughput

0.479

High

847827

PRP42
U1 small nuclear ribonucleoprotein component PRP42

1

20

High-throughput

0.479

High

847843

BBP
Branchpoint-bridging protein

1

1

Small-scale

0.479

High

847848

PRP46
Pre-mRNA-splicing factor PRP46

1

15

High-throughput

0.479

High

654729

SPA2
Protein SPA2

1

1

High-throughput

0.464

High

603069

EST1
Telomere elongation protein EST1

1

0

High-throughput

0.458

High

781563

NTR2
Pre-mRNA-splicing factor NTR2

1

0

High-throughput

0.458

High

797310

SP381
Pre-mRNA-splicing factor SPP381

1

0

High-throughput

0.458

High

797675

NTC20
Pre-mRNA-splicing factor NTC20

1

0

High-throughput

0.458

High

847811

SYF2
Pre-mRNA-splicing factor SYF2

1

0

High-throughput

0.458

High

847812

CWC22
Pre-mRNA-splicing factor CWC22

1

0

High-throughput

0.458

High

847826

CWC15
Pre-mRNA-splicing factor CWC15

1

0

High-throughput

0.458

High

524298

HSP71
Heat shock protein SSA1

1

5

High-throughput

0.445

High

526974

HSP72
Heat shock protein SSA2

1

5

High-throughput

0.445

High

545283

SSB1
Ribosome-associated molecular chaperone SSB1

1

4

High-throughput

0.445

High

741802

HSP7F
Heat shock protein homolog SSE1

1

8

High-throughput

0.445

High

811336

CAJ1
Protein CAJ1

1

2

High-throughput

0.445

High

819051

SSB2
Ribosome-associated molecular chaperone SSB2

1

4

High-throughput

0.445

High

810711

TCPB
T-complex protein 1 subunit beta

1

0

High-throughput

0.426

High

823267

JEM1
DnaJ-like chaperone JEM1

1

2

High-throughput

0.407

High

847819

ARG56
Protein ARG5,6, mitochondrial [Cleaved into: N-acetyl-gamma-glutamyl-phosphate reductase

1

0

High-throughput

0.269

Low

847844

YOR97
Uncharacterized protein YOR097C

1

0

High-throughput

0.269

Low

847830

VBA1
Vacuolar basic amino acid transporter 1

1

0

High-throughput

0.265

Low


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Last updated: 11Aug2025