HitPredict

Interactor 1: PP2BC (P48454)
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin, testis-specific catalytic subunit) (Calmodulin-dependent calcineurin A subunit gamma isoform)
Gene: PPP3CC

Interactor 2: CANB1 (P63098)
Calcineurin subunit B type 1 (Protein phosphatase 2B regulatory subunit 1) (Protein phosphatase 3 regulatory subunit B alpha isoform 1)
Gene: PPP3R1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.90 1.00 0.950

The method score is based on:

Property Details
Experiments 26186194, 27880917, 28514442, 32296183, 33961781, unassigned1304
Identification Methods affinity chromatography technology, two hybrid, two hybrid prey pooling approach, two hybrid array, anti tag coimmunoprecipitation, validated two hybrid
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains EF-hand_7~Metallophos
Common GO terms GO:0004723 - calcium-dependent protein serine/threonine phosphatase activity
GO:0005516 - calmodulin binding
GO:0005829 - cytosol
GO:0005955 - calcineurin complex
GO:0008287 - protein serine/threonine phosphatase complex
and 6 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 512
Hs

1 170
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+ Ce
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+ Sp
+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024