Interactor 1: KCNJ5 (P48544)
G protein-activated inward rectifier potassium channel 4 (GIRK-4) (Cardiac inward rectifier) (CIR) (Heart KATP channel) (Inward rectifier K(+) channel Kir3.4) (IRK-4) (KATP-1) (Potassium channel, inwardly rectifying subfamily J member 5)
Gene: KCNJ5

Interactor 2: KCNJ3 (P48549)
G protein-activated inward rectifier potassium channel 1 (GIRK-1) (Inward rectifier K(+) channel Kir3.1) (Potassium channel, inwardly rectifying subfamily J member 3)
Gene: KCNJ3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.866

The method score is based on:

Property Details
Experiments 9108307, 28514442, 33961781
Identification Methods pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains IRK~IRK, IRK~IRK_C, IRK_C~IRK_C
Common GO terms GO:0005886 - plasma membrane
GO:0006813 - potassium ion transport
GO:0008076 - voltage-gated potassium channel complex
GO:0015467 - G-protein activated inward rectifier potassium channel activity
GO:0034765 - regulation of monoatomic ion transmembrane transport
and 6 others

more...

Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 419
Hs

1 501
+ Bt
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Mm
+ Hs
+ Mm
+ Gg
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024