Protein: ERG25
C-4 methylsterol oxidase ERG25 (EC 1.14.18.-) (Ergosterol biosynthetic protein 25) (Sterol-C4-methyl oxidase ERG25) (SMO)

Gene: ERG25
Organism: Saccharomyces cerevisiae S288C
Interactions: 116
UniProt ID: P53045

Gene Ontology (top 5):
GO:0000170 - sphingosine hydroxylase activity
GO:0000248 - C-5 sterol desaturase activity
GO:0000254 - C-4 methylsterol oxidase activity
GO:0005506 - iron ion binding
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

858749

ERG27
3-keto-steroid reductase ERG27

3

1

Small-scale

0.680

High

767127

ERG28
Ergosterol biosynthetic protein 28

3

2

Small-scale

0.678

High

747409

PHO88
SRP-independent targeting protein 3

3

2

High-throughput

0.669

High

858725

ERG26
Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating

3

2

Small-scale

0.660

High

495851

CP51
Lanosterol 14-alpha demethylase CYP51

2

3

Small-scale

0.632

High

688610

ERG3
Delta(7)-sterol 5(6)-desaturase ERG3

2

4

Small-scale

0.632

High

690787

ERG1
Squalene epoxidase ERG1

2

1

Small-scale

0.632

High

858735

GSF2
Glucose-signaling factor 2

2

2

High-throughput

0.614

High

858722

ERG25
C-4 methylsterol oxidase ERG25

2

4

Small-scale

0.613

High

772453

ALG5
Dolichyl-phosphate beta-glucosyltransferase

2

0

High-throughput

0.605

High

809666

PHO86
Inorganic phosphate transporter PHO86

2

1

High-throughput

0.577

High

491859

HSP71
Heat shock protein SSA1

2

5

High-throughput

0.571

High

512027

SSB1
Ribosome-associated molecular chaperone SSB1

2

4

High-throughput

0.571

High

643191

PPZ1
Serine/threonine-protein phosphatase PP-Z1

2

2

High-throughput

0.559

High

439600

PSS
CDP-diacylglycerol--serine O-phosphatidyltransferase

1

1

High-throughput

0.541

High

626466

ERG6
Sterol 24-C-methyltransferase ERG6

1

1

Small-scale

0.541

High

629482

ERG4
Delta(24(24(1)))-sterol reductase ERG4

1

1

Small-scale

0.541

High

630133

ELO2
Fatty acid elongase 2

1

6

High-throughput

0.541

High

630737

AGP1
General amino acid permease AGP1

1

2

High-throughput

0.541

High

659181

LAC1
Ceramide synthase LAC1

1

1

High-throughput

0.541

High

669539

ERG9
Squalene synthase ERG9

1

1

Small-scale

0.541

High

698443

EMP24
Endosomal protein P24B

1

3

High-throughput

0.541

High

728050

YET1
Endoplasmic reticulum transmembrane protein 1

1

1

High-throughput

0.541

High

732005

SRPB
Signal recognition particle receptor subunit beta

1

2

High-throughput

0.541

High

747825

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

1

2

High-throughput

0.541

High

749043

SSH1
Sec sixty-one protein homolog

1

1

High-throughput

0.541

High

750090

CUE1
Coupling of ubiquitin conjugation to ER degradation protein 1

1

1

High-throughput

0.541

High

750808

ERG7
Lanosterol synthase ERG7

1

1

Small-scale

0.541

High

752773

LAG1
Ceramide synthase LAG1

1

1

High-throughput

0.541

High

756122

YHU0
UPF0641 membrane protein YHR140W

1

1

High-throughput

0.541

High

762818

UIP3
ULP1-interacting protein 3

1

1

High-throughput

0.541

High

763473

ERP2
Protein ERP2

1

6

High-throughput

0.541

High

771629

ELO3
Fatty acid elongase 3

1

6

High-throughput

0.541

High

775436

SNL1
HSP70 co-chaperone SNL1

1

1

High-throughput

0.541

High

809714

GPI2
Phosphatidylinositol N-acetylglucosaminyltransferase GPI2 subunit

1

1

High-throughput

0.541

High

809779

SPC1
Signal peptidase complex subunit 1

1

1

High-throughput

0.541

High

858724

MST27
Multicopy suppressor of SEC21 protein 27

1

1

High-throughput

0.541

High

858728

ERG5
C-22 sterol desaturase ERG5

1

1

Small-scale

0.541

High

858729

TMEDA
Endoplasmic reticulum vesicle protein 25

1

6

High-throughput

0.541

High

858730

SHR3
Secretory component protein SHR3

1

1

High-throughput

0.541

High

858731

GAS3
Probable 1,3-beta-glucanosyltransferase GAS3

1

1

High-throughput

0.541

High

858737

ERP1
Protein ERP1

1

6

High-throughput

0.541

High

858738

GAS2
1,3-beta-glucanosyltransferase GAS2

1

1

High-throughput

0.541

High

858739

ORM2
Protein ORM2

1

2

High-throughput

0.541

High

858741

SPO75
Sporulation-specific protein 75

1

2

High-throughput

0.541

High

858742

TPO1
Polyamine transporter 1

1

3

High-throughput

0.541

High

858745

PFA4
Palmitoyltransferase PFA4

1

1

High-throughput

0.541

High

858748

ERP4
Protein ERP4

1

6

High-throughput

0.541

High

520281

HMDH1
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

1

0

High-throughput

0.518

High

520386

TRK1
High-affinity potassium transport protein

1

0

High-throughput

0.518

High

561989

ALG1
Chitobiosyldiphosphodolichol beta-mannosyltransferase

1

0

High-throughput

0.518

High

576242

ERD2
ER lumen protein-retaining receptor

1

0

High-throughput

0.518

High

688580

ERG2
C-8 sterol isomerase ERG2

1

0

Small-scale

0.518

High

748005

YPC1
Alkaline ceramidase YPC1

1

0

High-throughput

0.518

High

759009

HXT6
High-affinity hexose transporter HXT6

1

0

High-throughput

0.518

High

770357

ERG29
Ergosterol biosynthesis protein 29

1

0

High-throughput

0.518

High

778716

PMP2
Plasma membrane ATPase proteolipid 2

1

0

High-throughput

0.518

High

784260

VMA21
Vacuolar ATPase assembly integral membrane protein VMA21

1

0

High-throughput

0.518

High

812482

STE24
CAAX prenyl protease 1

1

0

High-throughput

0.518

High

812497

ILM1
Protein ILM1

1

0

High-throughput

0.518

High

858726

ERV29
ER-derived vesicles protein ERV29

1

0

High-throughput

0.518

High

858736

SPC2
Signal peptidase complex subunit 2

1

0

High-throughput

0.518

High

858747

YOP1
Protein YOP1

1

0

High-throughput

0.518

High

858750

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.518

High

701508

SC61A
Protein transport protein SEC61

1

1

High-throughput

0.494

High

744844

YB91
Probable metabolite transport protein YBR241C

1

1

High-throughput

0.494

High

784487

BAP3
Valine amino-acid permease

1

2

High-throughput

0.494

High

858744

YP264
Probable transport protein YPL264C

1

1

High-throughput

0.494

High

771500

CYB5
Cytochrome b5

1

5

High-throughput

0.479

High

858751

ENV10
SRP-independent targeting protein 2

1

2

High-throughput

0.479

High

474098

AQY1
Aquaporin-1

1

0

High-throughput

0.460

High

340715

PGK
Phosphoglycerate kinase

1

0

High-throughput

0.458

High

597001

ACO1
Acyl-CoA desaturase 1

1

0

High-throughput

0.458

High

766010

SPF1
Endoplasmic reticulum transmembrane helix translocase

1

0

High-throughput

0.458

High

494470

HSP72
Heat shock protein SSA2

1

5

High-throughput

0.445

High

636682

CDC48
Cell division control protein 48

1

1

High-throughput

0.445

High

704051

PDR5
Pleiotropic ABC efflux transporter of multiple drugs

1

2

High-throughput

0.445

High

768947

SSB2
Ribosome-associated molecular chaperone SSB2

1

4

High-throughput

0.445

High

858727

COPA
Coatomer subunit alpha

1

1

High-throughput

0.437

High

858734

DHR1
Probable ATP-dependent RNA helicase DHR1

1

1

High-throughput

0.437

High

751395

FKS1
1,3-beta-glucan synthase component FKS1

1

0

High-throughput

0.426

High

837525

MNN10
Probable alpha-1,6-mannosyltransferase MNN10

1

0

High-throughput

0.426

High

858733

USA1
U1 SNP1-associating protein 1

1

0

High-throughput

0.426

High

360961

TBB
Tubulin beta chain

1

1

High-throughput

0.407

High

368236

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.407

High

399554

RLA0
Large ribosomal subunit protein uL10

1

1

High-throughput

0.407

High

454405

TBA1
Tubulin alpha-1 chain

1

1

High-throughput

0.407

High

498999

RL4A
Large ribosomal subunit protein uL4A

1

1

High-throughput

0.407

High

556172

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.407

High

588157

HSP60
Heat shock protein 60, mitochondrial

1

1

High-throughput

0.407

High

746522

IMB2
Importin subunit beta-2

1

1

High-throughput

0.407

High

767691

IMB4
Importin subunit beta-4

1

1

High-throughput

0.407

High

784174

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.407

High

604742

EPT1
Choline/ethanolaminephosphotransferase 1

1

0

High-throughput

0.282

High

734107

TVP38
Golgi apparatus membrane protein TVP38

1

0

High-throughput

0.282

High

775318

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.282

High

842754

AVT4
Vacuolar amino acid transporter 4

1

0

High-throughput

0.282

High

858746

RBD2
Rhomboid-type serine protease 2

1

0

High-throughput

0.282

High

535252

RS17B
Small ribosomal subunit protein eS17B

1

0

High-throughput

0.249

Low

619493

PSA2
Proteasome subunit alpha type-2

1

0

High-throughput

0.249

Low

634689

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.249

Low

762390

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

858740

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

771536

SECU
Securin

1

0

High-throughput

0.238

Low

858743

RBX1
RING-box protein HRT1

1

0

High-throughput

0.238

Low

423476

PUR2
Bifunctional purine biosynthetic protein ADE5,7 [Includes: Phosphoribosylamine--glycine ligase

1

0

High-throughput

0.232

Low

424614

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.232

Low

619611

MPCP
Mitochondrial phosphate carrier protein

1

0

High-throughput

0.232

Low

667228

RL8B
Large ribosomal subunit protein eL8B

1

0

High-throughput

0.232

Low

752940

YHI0
Putative proline--tRNA ligase YHR020W

1

0

High-throughput

0.232

Low

753888

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.232

Low

766397

GEA2
ARF guanine-nucleotide exchange factor 2

1

0

High-throughput

0.232

Low

785111

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low

858723

DXO
Decapping nuclease RAI1

1

0

High-throughput

0.232

Low

858732

CLU
Clustered mitochondria protein 1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024