HitPredict

Interactor 1: TCPE (P48643)
T-complex protein 1 subunit epsilon (TCP-1-epsilon) (CCT-epsilon) (Chaperonin containing T-complex polypeptide 1 subunit 5)
Gene: CCT5

Interactor 2: HDAC6 (Q9UBN7)
Histone deacetylase 6 (HD6) (EC 3.5.1.98) (Protein deacetylase HDAC6) (EC 3.5.1.-) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-)
Gene: HDAC6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	26643866, 35676659, 23703321
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005813 - centrosome GO:0005829 - cytosol GO:0005874 - microtubule GO:0048487 - beta-tubulin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 541 Hs			1 1215
+	Hs
		826927 TCPG_HUMAN (14-540): 0: 572: 33.15		HDAC6_HUMAN (1-1215): 0: 1435: 100.00
+	Hs
		1306720 TCPH_HUMAN (12-539): 0: 570: 29.64		HDAC6_HUMAN (1-1215): 0: 1435: 100.00
+	Hs
		821200 TCPE_HUMAN (1-541): 0: 635: 100.00		HDAC1_HUMAN (478-896): 4.05e-166: 503: 20.09
+	Hs
		821342 TCPE_HUMAN (1-541): 0: 635: 100.00		HDAC2_HUMAN (78-489): 1.04e-157: 481: 21.02
+	Mm
		945965 TCPE_MOUSE (1-541): 0: 627: 96.30		HDAC4_MOUSE (424-873): 9e-152: 485: 37.16
+	Hs
		821140 TCPE_HUMAN (1-541): 0: 635: 100.00		HDAC4_HUMAN (405-873): 1.97e-147: 474: 36.51
+	Hs
		821464 TCPE_HUMAN (1-541): 0: 635: 100.00		HDAC5_HUMAN (33-471): 3.29e-145: 469: 32.48
+	Hs
		177231 TCPE_HUMAN (1-541): 0: 635: 100.00		HDAC3_HUMAN (479-890): 6.6e-146: 448: 18.29
+	Hs
		826651 TCPG_HUMAN (14-540): 0: 572: 33.15		HDAC1_HUMAN (478-896): 4.05e-166: 503: 20.09
+	Hs
		1038670 TCPH_HUMAN (12-539): 0: 570: 29.64		HDAC1_HUMAN (478-896): 4.05e-166: 503: 20.09
+	Mm
		945920 TCPH_MOUSE (12-539): 0: 575: 29.46		HDAC4_MOUSE (424-873): 9e-152: 485: 37.16
+	Hs
		826803 TCPG_HUMAN (14-540): 0: 572: 33.15		HDAC2_HUMAN (78-489): 1.04e-157: 481: 21.02
+	Hs
		573251 TCPA_HUMAN (26-541): 0: 545: 32.08		HDAC1_HUMAN (478-896): 4.05e-166: 503: 20.09
+	Hs
		826942 TCPG_HUMAN (14-540): 0: 572: 33.15		HDAC5_HUMAN (33-471): 3.29e-145: 469: 32.48
+	Sc
		693029 TCPE_YEAST (3-540): 0: 582: 59.89		RPD3_YEAST (75-473): 1.1e-149: 458: 20.24
+	Hs
		1306741 TCPH_HUMAN (12-539): 0: 570: 29.64		HDAC5_HUMAN (33-471): 3.29e-145: 469: 32.48
+	Hs
		573401 TCPA_HUMAN (26-541): 0: 545: 32.08		HDAC2_HUMAN (78-489): 1.04e-157: 481: 21.02
+	Hs
		177233 TCPG_HUMAN (14-540): 0: 572: 33.15		HDAC3_HUMAN (479-890): 6.6e-146: 448: 18.29
+	Hs
		177367 TCPH_HUMAN (12-539): 0: 570: 29.64		HDAC3_HUMAN (479-890): 6.6e-146: 448: 18.29
+	Hs
		177188 TCPA_HUMAN (26-541): 0: 545: 32.08		HDAC3_HUMAN (479-890): 6.6e-146: 448: 18.29